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steroid 5 alpha-reductase 2

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Target not currently curated in GtoImmuPdb

Target id: 2633

Nomenclature: steroid 5 alpha-reductase 2

Family: 1.-.-.- Oxidoreductases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 254 2p23.1 SRD5A2 steroid 5 alpha-reductase 2
Mouse 4 254 17 E2 Srd5a2 steroid 5 alpha-reductase 2
Rat 4 254 6q14 Srd5a2 steroid 5 alpha-reductase 2
Previous and Unofficial Names Click here for help
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Database Links Click here for help
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
finasteride Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.46x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
Synonyms: Pseudovaginal perineoscrotal hypospadias; PPSH [OMIM: 264600]
OMIM: 264600
Orphanet: ORPHA753
Disease:  Familial prostate cancer
Synonyms: Prostate cancer [OMIM: 176807] [Disease Ontology: DOID:10283]
Disease Ontology: DOID:10283
OMIM: 176807
Orphanet: ORPHA1331


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1. Rasmusson GH, Reynolds GF, Steinberg NG, Walton E, Patel GF, Liang T, Cascieri MA, Cheung AH, Brooks JR, Berman C. (1986) Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding. J Med Chem, 29 (11): 2298-315. [PMID:3783591]

How to cite this page

1.-.-.- Oxidoreductases: steroid 5 alpha-reductase 2. Last modified on 30/03/2016. Accessed on 18/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,