steroid 5 alpha-reductase 2 | 1.-.-.- Oxidoreductases | IUPHAR/BPS Guide to PHARMACOLOGY

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steroid 5 alpha-reductase 2

Target not currently curated in GtoImmuPdb

Target id: 2633

Nomenclature: steroid 5 alpha-reductase 2

Family: 1.-.-.- Oxidoreductases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 254 2p23.1 SRD5A2 steroid 5 alpha-reductase 2
Mouse - 254 17 E2 Srd5a2 steroid 5 alpha-reductase 2
Rat - 254 6q13 Srd5a2 steroid 5 alpha-reductase 2
Previous and Unofficial Names
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
finasteride Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.46x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency
Synonyms: Pseudovaginal perineoscrotal hypospadias; PPSH [OMIM: 264600]
OMIM: 264600
Orphanet: ORPHA753
Disease:  Familial prostate cancer
Synonyms: Prostate cancer [OMIM: 176807] [Disease Ontology: DOID:10283]
Disease Ontology: DOID:10283
OMIM: 176807
Orphanet: ORPHA1331


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1. Rasmusson GH, Reynolds GF, Steinberg NG, Walton E, Patel GF, Liang T, Cascieri MA, Cheung AH, Brooks JR, Berman C. (1986) Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding. J. Med. Chem., 29 (11): 2298-315. [PMID:3783591]

How to cite this page

1.-.-.- Oxidoreductases: steroid 5 alpha-reductase 2. Last modified on 30/03/2016. Accessed on 13/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY,