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Synonyms: MABp1 | RA-18C3 | Xilonix® (proposed trade name)
Compound class: Antibody
Comment: Bermekimab (MABp1, Xilonix) is an investigational fully human monoclonal antibody targeting IL-1α, with potential antiinflammatory action. This antibody is the first genuinely human monoclonal antibody to be produced directly from an affinity matured, human immune response. As MABp1 has not been subject to in vitro sequence modification it is predicted to have improved tolerability compared to antibodies that are 'humanised'.
A patent search suggests that Xilonix is the subject of WO2009148575 .
|International Nonproprietary Names|
|MABp1 | RA-18C3 | Xilonix® (proposed trade name)|
|GtoPdb PubChem SID||249565769|
|Search PubMed clinical trials||bermekimab|
|Search PubMed titles||bermekimab|
|Search PubMed titles/abstracts||bermekimab|