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ChEMBL ligand: CHEMBL288064 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
ChEMBL | Inhibition of CDK1/cyclinB | B | 5 | pIC50 | 10000 | nM | IC50 | Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
ChEMBL | Inhibition of human recombinant GSK3alpha | B | 6.41 | pIC50 | 390 | nM | IC50 | J Med Chem (2012) 55: 4407-4424 [PMID:22533818] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of human recombinant GSK3beta using pIRS-1 as substrate preincubated for 15 mins | B | 6.1 | pIC50 | 790 | nM | IC50 | J Med Chem (2012) 55: 4407-4424 [PMID:22533818] |
ChEMBL | Inhibitory concentration against human Glycogen synthase kinase-3 | B | 6.41 | pIC50 | 390 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 1525-1528 [PMID:12031334] |
ChEMBL | Inhibition of GSK3-beta | B | 6.41 | pIC50 | 390 | nM | IC50 | Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249] |
ChEMBL | Inhibition of GSK3beta (unknown origin) | B | 6.41 | pIC50 | 390 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1532-1537 [PMID:24560539] |
GtoPdb | - | - | 6.41 | pIC50 | 390 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 1525-8 [PMID:12031334] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]