GSK-3beta inhibitor II [Ligand Id: 5978] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL288064
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  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067P06493P14635Q8WWL7]
ChEMBL Inhibition of CDK1/cyclinB B 5 pIC50 10000 nM IC50 Trends Pharmacol. Sci. (2004) 25: 471-480 [PMID:15559249]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Inhibition of human recombinant GSK3alpha B 6.41 pIC50 390 nM IC50 J. Med. Chem. (2012) 55: 4407-4424 [PMID:22533818]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of human recombinant GSK3beta using pIRS-1 as substrate preincubated for 15 mins B 6.1 pIC50 790 nM IC50 J. Med. Chem. (2012) 55: 4407-4424 [PMID:22533818]
ChEMBL Inhibitory concentration against human Glycogen synthase kinase-3 B 6.41 pIC50 390 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 1525-1528 [PMID:12031334]
ChEMBL Inhibition of GSK3-beta B 6.41 pIC50 390 nM IC50 Trends Pharmacol. Sci. (2004) 25: 471-480 [PMID:15559249]
ChEMBL Inhibition of GSK3beta (unknown origin) B 6.41 pIC50 390 nM IC50 Bioorg. Med. Chem. Lett. (2014) 24: 1532-1537 [PMID:24560539]
GtoPdb - - 6.41 pIC50 390 nM IC50 Bioorg Med Chem Lett (2002) 12: 1525-8 [PMID:12031334]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]