SU5402 [Ligand Id: 11743] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL89363 (SU-5402) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Evaluated for inhibitory activity towards tyrosine kinase Epidermal growth factor receptor | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
| ChEMBL | Inhibitory activity against Epidermal growth factor receptor | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1999) 42: 5120-5130 [PMID:10602697] |
| ChEMBL | Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK). | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1998) 41: 2588-2603 [PMID:9651163] |
| ChEMBL | Inhibitory activity against ligand-dependent EGF cell proliferation | F | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (1999) 42: 5120-5130 [PMID:10602697] |
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| ChEMBL | Inhibition of bFGF-mediated tyrosine phosphorylation | F | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (2000) 43: 4200-4211 [PMID:11063616] |
| ChEMBL | Inhibition of FGFR1K autophosphorylation activity assessed as [32P] incorporation | B | 5 | pIC50 | 10000 | nM | IC50 | Science (1997) 276: 955-960 [PMID:9139660] |
| ChEMBL | Inhibition of FGFR1 kinase domain (unknown origin) | B | 5 | pIC50 | 10000 | nM | IC50 | Eur J Med Chem (2017) 126: 476-490 [PMID:27914362] |
| ChEMBL | Inhibitory activity of compound against FGF induced cell proliferation | F | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (1999) 42: 5120-5130 [PMID:10602697] |
| ChEMBL | Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA | B | 6.48 | pIC50 | 334 | nM | IC50 | J Med Chem (2011) 54: 3732-3745 [PMID:21517068] |
| GtoPdb | - | - | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (1999) 42: 5120-30 [PMID:10602697] |
| ChEMBL | Evaluated for inhibitory activity towards Fibroblast growth factor receptor 1 | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
| ChEMBL | Inhibitory activity against Fibroblast growth factor receptor 1 | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (1999) 42: 5120-5130 [PMID:10602697] |
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3960] [GtoPdb: 1808] [UniProtKB: P16092] | ||||||||
| ChEMBL | Inhibition of acidic FGF-stimulated FGFR1 tyrosine autophosphorylation in mouse NIH/3T3 cells by immunoblotting | B | 5 | pIC50 | 10000 | nM | IC50 | Science (1997) 276: 955-960 [PMID:9139660] |
| ChEMBL | Inhibition of FGF induced FGFR1 autophosphorylation in mouse NIH 3T3 cells preincubated for 5 mins followed by FGF-stimulation for 5 mins in presence of [gamma-32P]ATP by SDS-PAGE based autoradiography | B | 5 | pIC50 | 10000 | nM | IC50 | Eur J Med Chem (2017) 126: 476-490 [PMID:27914362] |
| Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
| ChEMBL | Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1998) 41: 2588-2603 [PMID:9651163] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK). | B | 4.22 | pIC50 | 60900 | nM | IC50 | J Med Chem (1998) 41: 2588-2603 [PMID:9651163] |
| ChEMBL | Inhibitory activity of compound against PDGF induced cell proliferation | F | 4.55 | pIC50 | 28400 | nM | IC50 | J Med Chem (1999) 42: 5120-5130 [PMID:10602697] |
| GtoPdb | - | - | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (1999) 42: 5120-30 [PMID:10602697] |
| ChEMBL | Evaluated for inhibitory activity towards tyrosine kinase PDGF-Rbeta | B | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
| ChEMBL | Inhibitory activity against Platelet-derived growth factor receptor beta | B | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (1999) 42: 5120-5130 [PMID:10602697] |
| erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
| ChEMBL | Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK) | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1998) 41: 2588-2603 [PMID:9651163] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Evaluated for inhibitory activity towards p60 c-Src tyrosine kinase | B | 4.97 | pIC50 | 10600 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
| fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3516] [GtoPdb: 1812] [UniProtKB: P35969] | ||||||||
| ChEMBL | Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK). | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1998) 41: 2588-2603 [PMID:9651163] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Inhibitory activity of compound against VEGF induced cell proliferation | F | 7.3 | pIC50 | 50 | nM | IC50 | J Med Chem (1999) 42: 5120-5130 [PMID:10602697] |
| ChEMBL | Evaluated for inhibitory activity towards tyrosine kinase Vascular endothelial growth factor receptor 2 | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2000) 43: 2655-2663 [PMID:10893303] |
| ChEMBL | Inhibitory activity against Vascular endothelial growth factor receptor 2 | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1999) 42: 5120-5130 [PMID:10602697] |
| ChEMBL | Inhibition of KDR | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2126-2133 [PMID:17306530] |
| GtoPdb | - | - | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1999) 42: 5120-30 [PMID:10602697] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
