ChEMBL ligand: CHEMBL89363 (SU-5402)
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Mouse [ChEMBL: CHEMBL3960] [GtoPdb: 1808] [UniProtKB: P16092] There should be some charts here, you may need to enable JavaScript!
Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] There should be some charts here, you may need to enable JavaScript!
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] There should be some charts here, you may need to enable JavaScript!
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Mouse [ChEMBL: CHEMBL3516] [GtoPdb: 1812] [UniProtKB: P35969] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Evaluated for inhibitory activity towards tyrosine kinase Epidermal growth factor receptor	B	4	pIC50	>100000	nM	IC50	J Med Chem (2000) 43: 2655-2663 [PMID:10893303]
ChEMBL	Inhibitory activity against Epidermal growth factor receptor	B	4	pIC50	>100000	nM	IC50	J Med Chem (1999) 42: 5120-5130 [PMID:10602697]
ChEMBL	Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).	B	4	pIC50	>100000	nM	IC50	J Med Chem (1998) 41: 2588-2603 [PMID:9651163]
ChEMBL	Inhibitory activity against ligand-dependent EGF cell proliferation	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (1999) 42: 5120-5130 [PMID:10602697]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL	Inhibition of bFGF-mediated tyrosine phosphorylation	F	4.7	pIC50	20000	nM	IC50	J Med Chem (2000) 43: 4200-4211 [PMID:11063616]
ChEMBL	Inhibition of FGFR1K autophosphorylation activity assessed as [32P] incorporation	B	5	pIC50	10000	nM	IC50	Science (1997) 276: 955-960 [PMID:9139660]
ChEMBL	Inhibition of FGFR1 kinase domain (unknown origin)	B	5	pIC50	10000	nM	IC50	Eur J Med Chem (2017) 126: 476-490 [PMID:27914362]
ChEMBL	Inhibitory activity of compound against FGF induced cell proliferation	F	5.55	pIC50	2800	nM	IC50	J Med Chem (1999) 42: 5120-5130 [PMID:10602697]
ChEMBL	Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISA	B	6.48	pIC50	334	nM	IC50	J Med Chem (2011) 54: 3732-3745 [PMID:21517068]
GtoPdb	-	-	7.52	pIC50	30	nM	IC50	J Med Chem (1999) 42: 5120-30 [PMID:10602697]
ChEMBL	Evaluated for inhibitory activity towards Fibroblast growth factor receptor 1	B	7.52	pIC50	30	nM	IC50	J Med Chem (2000) 43: 2655-2663 [PMID:10893303]
ChEMBL	Inhibitory activity against Fibroblast growth factor receptor 1	B	7.52	pIC50	30	nM	IC50	J Med Chem (1999) 42: 5120-5130 [PMID:10602697]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3960] [GtoPdb: 1808] [UniProtKB: P16092]
ChEMBL	Inhibition of acidic FGF-stimulated FGFR1 tyrosine autophosphorylation in mouse NIH/3T3 cells by immunoblotting	B	5	pIC50	10000	nM	IC50	Science (1997) 276: 955-960 [PMID:9139660]
ChEMBL	Inhibition of FGF induced FGFR1 autophosphorylation in mouse NIH 3T3 cells preincubated for 5 mins followed by FGF-stimulation for 5 mins in presence of [gamma-32P]ATP by SDS-PAGE based autoradiography	B	5	pIC50	10000	nM	IC50	Eur J Med Chem (2017) 126: 476-490 [PMID:27914362]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL	Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptor	B	4	pIC50	>100000	nM	IC50	J Med Chem (1998) 41: 2588-2603 [PMID:9651163]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL	Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).	B	4.22	pIC50	60900	nM	IC50	J Med Chem (1998) 41: 2588-2603 [PMID:9651163]
ChEMBL	Inhibitory activity of compound against PDGF induced cell proliferation	F	4.55	pIC50	28400	nM	IC50	J Med Chem (1999) 42: 5120-5130 [PMID:10602697]
GtoPdb	-	-	6.29	pIC50	510	nM	IC50	J Med Chem (1999) 42: 5120-30 [PMID:10602697]
ChEMBL	Evaluated for inhibitory activity towards tyrosine kinase PDGF-Rbeta	B	6.29	pIC50	510	nM	IC50	J Med Chem (2000) 43: 2655-2663 [PMID:10893303]
ChEMBL	Inhibitory activity against Platelet-derived growth factor receptor beta	B	6.29	pIC50	510	nM	IC50	J Med Chem (1999) 42: 5120-5130 [PMID:10602697]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL	Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)	B	4	pIC50	>100000	nM	IC50	J Med Chem (1998) 41: 2588-2603 [PMID:9651163]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Evaluated for inhibitory activity towards p60 c-Src tyrosine kinase	B	4.97	pIC50	10600	nM	IC50	J Med Chem (2000) 43: 2655-2663 [PMID:10893303]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3516] [GtoPdb: 1812] [UniProtKB: P35969]
ChEMBL	Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).	B	6.4	pIC50	400	nM	IC50	J Med Chem (1998) 41: 2588-2603 [PMID:9651163]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibitory activity of compound against VEGF induced cell proliferation	F	7.3	pIC50	50	nM	IC50	J Med Chem (1999) 42: 5120-5130 [PMID:10602697]
ChEMBL	Evaluated for inhibitory activity towards tyrosine kinase Vascular endothelial growth factor receptor 2	B	7.7	pIC50	20	nM	IC50	J Med Chem (2000) 43: 2655-2663 [PMID:10893303]
ChEMBL	Inhibitory activity against Vascular endothelial growth factor receptor 2	B	7.7	pIC50	20	nM	IC50	J Med Chem (1999) 42: 5120-5130 [PMID:10602697]
ChEMBL	Inhibition of KDR	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2007) 17: 2126-2133 [PMID:17306530]
GtoPdb	-	-	7.7	pIC50	20	nM	IC50	J Med Chem (1999) 42: 5120-30 [PMID:10602697]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]