ChEMBL ligand: CHEMBL439259 (TCMDC-125497)
Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL	Inhibition of recombinant IGF1R by ELISA	B	4.73	pIC50	18700	nM	IC50	Bioorg Med Chem (2010) 18: 5995-6005 [PMID:20643554]
ChEMBL	Inhibition of IGF1R-dependent tumor cell growth in human MCNeuA cells	B	4.82	pIC50	15000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL	Inhibition of IGF1R autophosphorylation in human MCF7 cells	B	4.92	pIC50	12000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL	Inhibition of IGF1R autophosphorylation in human MCF7 cells by ELISA	B	4.92	pIC50	12000	nM	IC50	J Med Chem (2009) 52: 4981-5004 [PMID:19610618]
ChEMBL	Inhibition of IGF1R-dependent tumor cell growth in human MCF7 cells	B	5.1	pIC50	8000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb	-	-	6	pIC50	<1000	nM	IC50	Mol Cancer Ther (2006) 5: 1079-86 [PMID:16648580]
ChEMBL	Inhibition of IGF1R autophosphorylation in human MCF7 cells by Western blot analysis	B	6	pIC50	<1000	nM	IC50	J Med Chem (2009) 52: 4981-5004 [PMID:19610618]
ChEMBL	Inhibition of IGF1R autophosphorylation	B	6	pIC50	<1000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine incorporation after 72 hrs	F	6.41	pEC50	390	nM	EC50	ACS Med Chem Lett (2010) 1: 460-465 [PMID:21243104]
ChEMBL	Antimalarial activity against chloroquine-sensetive Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 72 hrs	F	7.28	pEC50	53	nM	EC50	ACS Med Chem Lett (2010) 1: 460-465 [PMID:21243104]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]