compound 27 [PMID: 21123062] [Ligand Id: 8210] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1644812 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Inhibition of human c-Met in human GTL16 cells by cell-based assay | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 164-167 [PMID:21123062] |
| ChEMBL | Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay | B | 7.36 | pIC50 | 44 | nM | IC50 | Bioorg Med Chem (2011) 19: 6274-6284 [PMID:21967808] |
| GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 164-7 [PMID:21123062] |
| ChEMBL | Inhibition of c-Met | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 164-167 [PMID:21123062] |
| ChEMBL | Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence assay | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem (2011) 19: 6274-6284 [PMID:21967808] |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Inhibition of IR kinase | B | 6.14 | pIC50 | 730 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 164-167 [PMID:21123062] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
