DEBIO1347

Ligand id: 9787

Name: DEBIO1347

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 104.86
Molecular weight 356.14
XLogP 3.44
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
[5-amino-1-(2-methyl-3H-benzimidazol-5-yl)pyrazol-4-yl]-(1H-indol-2-yl)methanone
Synonyms
CH5183284 | DEBIO-1347 | zotiraciclib (proposed INN)
Comments
DEBIO1347 is a FGFR1/2/3 inhibitor being investigated for antineoplastic activity [1]. The compound is ATP-competitive, potent and orally available.
Database Links
CAS Registry No. 1265229-25-1 (source: PubChem)
GtoPdb PubChem SID 354702260
PubChem CID 66555680
RCSB PDB Ligand LWJ
Search Google for chemical match using the InChIKey BEMNJULZEQTDJY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BEMNJULZEQTDJY
Search UniChem for chemical match using the InChIKey BEMNJULZEQTDJY-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone BEMNJULZEQTDJY