Synonyms: CH5183284 | DEBIO-1347 | DEBIO1347
Compound class:
Synthetic organic
Comment: Zoligratinib (DEBIO1347) is a FGFR1/2/3 inhibitor that is being investigated for antineoplastic activity [1]. The compound is ATP-competitive, potent and orally available.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
DEBIO347 inhibits FGFR1, -2, and -3 but does not inhibit kinase insert domain receptor (KDR) or other kinases [1]. It preferentially kills FGFR deranged cancer cells (compared to cells with normal FGFRs) in vitro and in vivo. |
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