PACAP-38 [Ligand Id: 2258] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PAC1 receptor in Human [GtoPdb: 370] [UniProtKB: P41586] | ||||||||
| GtoPdb | inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the PAC1 very short receptor | - | 6.9 | pKi | 121 | nM | Ki | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the PAC1 short receptor (ENST00000409363) | - | 8.8 | pKi | 1.7 | nM | Ki | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | inhibition of [125I]-PACAP-27 binding to membranes from HEK293 cells stably expressing the full length receptor (ENST00000304166) | - | 9 | pKi | 1.1 | nM | Ki | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | stimulation of cyclic AMP formation in HEK293 cells stably expressing the PAC1 very short receptor | - | 7.5 | pEC50 | 29 | nM | EC50 | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | calcium influx in CHO cells stably expressing recombinant receptor | - | 8.3 | pEC50 | 5.1 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | stimulation of cyclic AMP formation in HEK293 cells stably expressing the PAC1 short receptor (ENST00000409363) | - | 9.2 | pEC50 | 0.7 | nM | EC50 | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | stimulation of cyclic AMP formation in HEK293 cells stably expressing the full length receptor (ENST00000304166) | - | 9.2 | pEC50 | 0.6 | nM | EC50 | J Neuroendocrinol (1999) 11: 941-9 [PMID:10583729] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 10.3 | pEC50 | 0.05 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| PAC1 receptor in Rat [GtoPdb: 370] [UniProtKB: P32215] | ||||||||
| GtoPdb | inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the rat PAC1 receptor isoform lacking the hip and hop exons | - | 8.4 | pKi | 4 | nM | Ki | Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670] |
| GtoPdb | inhibition of [125I]-[Ac-His1]PACAP-27 binding to membranes from CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon | - | 8.8 | pKi | 1.5 | nM | Ki | Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670] |
| GtoPdb | stimulation of adenylate cyclase in COS cells transiently expressing recombinant receptor | - | 9.5 | pEC50 | 0.34 | nM | EC50 | J Biol Chem (1997) 272: 966-70 [PMID:8995389] |
| GtoPdb | stimulation of adenylate cyclase in CHO cells stably expressing the rat PAC1 receptor isoform including the hop1 exon | - | 10 | pEC50 | 0.1 | nM | EC50 | Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670] |
| GtoPdb | stimulation of adenylate cyclase in CHO cells stably expressing the rat PAC1 receptor isoform lacking the hip and hop exons | - | 10 | pEC50 | 0.1 | nM | EC50 | Eur J Pharmacol (1995) 288: 259-67 [PMID:7774670] |
| VPAC1 receptor in Human [GtoPdb: 371] [UniProtKB: P32241] | ||||||||
| GtoPdb | inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor | - | 8.2 | pKi | 6.8 | nM | Ki | Eur J Pharmacol (1996) 302: 207-14 [PMID:8791009] |
| GtoPdb | calcium influx in CHO cells stably expressing recombinant receptor | - | 7.4 | pEC50 | 37.4 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 9.7 | pEC50 | 0.22 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| VPAC2 receptor in Human [GtoPdb: 372] [UniProtKB: P41587] | ||||||||
| GtoPdb | calcium influx in CHO cells stably expressing recombinant receptor | - | 7.7 | pEC50 | 19.4 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
| GtoPdb | cyclic AMP formation in CHO cells stably expressing recombinant receptor | - | 9.3 | pEC50 | 0.53 | nM | EC50 | Neuropharmacology (2006) 51: 1086-98 [PMID:16930633] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
