L-367,773 [Ligand Id: 2246] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL338522 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OT receptor/Oxytocin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2049] [GtoPdb: 369] [UniProtKB: P30559] | ||||||||
| ChEMBL | Tested against human uterine OT receptor | B | 7.21 | pKi | 61 | nM | Ki | J Med Chem (1993) 36: 3993-4005 [PMID:8258821] |
| GtoPdb | - | - | 7.6 | pKi | - | - | - | Life Sci (1995) 57: 2253-61 [PMID:7475979] |
| OT receptor/Oxytocin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3996] [GtoPdb: 369] [UniProtKB: P70536] | ||||||||
| ChEMBL | Tested against rat uterine OT receptor | B | 7.59 | pKi | 26 | nM | Ki | J Med Chem (1993) 36: 3993-4005 [PMID:8258821] |
| ChEMBL | Inhibition of radioligand [3H]oxytocin binding at the oxytocin (OT) receptor in rat uterine tissue | B | 7.28 | pIC50 | 52 | nM | IC50 | J Med Chem (1993) 36: 3993-4005 [PMID:8258821] |
| V2 receptor/Vasopressin V2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3766] [GtoPdb: 368] [UniProtKB: Q00788] | ||||||||
| ChEMBL | Inhibition of radioligand [3H]-AVP binding to the vasopressin V2 receptor in rat kidney tissue | B | 4.77 | pIC50 | 17000 | nM | IC50 | J Med Chem (1993) 36: 3993-4005 [PMID:8258821] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
