indoximod [Ligand Id: 8226] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL571209 (1-methyltryptophan, d-, D-1-methyltryptophan, D-1MT, Indoximod, N-1-methyl-d-tryptophan, NLG-8189, NSC-721782) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902] | ||||||||
| ChEMBL | Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation by measuring inhibition constant by UV-visible spectroscopic analysis | B | 4.43 | pKi | 37000 | nM | Ki | Bioorg Med Chem Lett (2023) 96: 129532-129532 [PMID:37866714] |
| ChEMBL | Binding affinity to IDO1 (unknown origin) assessed as inhibition constant | B | 4.46 | pKi | 35000 | nM | Ki | Eur J Med Chem (2022) 238: 114524-114524 [PMID:35696861] |
| ChEMBL | Inhibition of human IDO1 | B | 4.47 | pKi | 34000 | nM | Ki | Eur J Med Chem (2022) 241: 114625-114625 [PMID:35952399] |
| ChEMBL | Binding affinity to IDO1 (unknown origin) | B | 4.47 | pKi | 34000 | nM | Ki | Eur J Med Chem (2022) 227: 113967-113967 [PMID:34752953] |
| ChEMBL | Binding affinity to human IDO1 assessed as inhibition constant | B | 4.72 | pKi | 19000 | nM | Ki | J Med Chem (2021) 64: 8303-8332 [PMID:34110158] |
| ChEMBL | Inhibition of human IDO1 | B | 1 | pIC50 | >100000000 | nM | IC50 | J Med Chem (2020) 63: 15115-15139 [PMID:33215494] |
| ChEMBL | Inhibition of human IDO1 assessed as reduction in kynurenine production | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2018) 143: 656-669 [PMID:29220788] |
| ChEMBL | Inhibition of recombinant human His-tagged IDO1 expressed in Escherichia coli BL21(DE3) cells assessed as inhibition of kynurenine production using L-tryptophan as substrate after 1 hr by fluorescence assay relative to control | B | 4.02 | pIC50 | 95600 | nM | IC50 | Bioorg Med Chem (2017) 25: 3780-3791 [PMID:28526475] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
