JNJ40355003 [Ligand Id: 9050] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2164602 (JNJ-40355003)
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
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  • Fatty acid amide hydrolase-2/Fatty-acid amide hydrolase 2 in Human [ChEMBL: CHEMBL1628475] [GtoPdb: 1401] [UniProtKB: Q6GMR7]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
GtoPdb - - 8.85 pIC50 1.4 nM IC50 ACS Med Chem Lett (2012) 3: 823-7 [PMID:24900385]
ChEMBL Inhibition of human FAAH after 1 hr B 8.85 pIC50 1.4 nM IC50 ACS Med. Chem. Lett. (2012) 3: 823-827 [PMID:24900385]
ChEMBL Inhibition of human FAAH preincubated for 60 mins B 8.85 pIC50 1.4 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7357-7362 [PMID:23141911]
ChEMBL Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation analysis B 8.85 pIC50 1.4 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3109-3114 [PMID:27189675]
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
GtoPdb - - 7.48 pIC50 33 nM IC50 ACS Med Chem Lett (2012) 3: 823-7 [PMID:24900385]
ChEMBL Inhibition of rat FAAH after 1 hr B 7.48 pIC50 33 nM IC50 ACS Med. Chem. Lett. (2012) 3: 823-827 [PMID:24900385]
ChEMBL Inhibition of rat FAAH preincubated for 60 mins B 7.48 pIC50 33 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 7357-7362 [PMID:23141911]
ChEMBL Apparent inhibition of recombinant rat FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation analysis B 7.48 pIC50 33 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3109-3114 [PMID:27189675]
Fatty acid amide hydrolase-2/Fatty-acid amide hydrolase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628475] [GtoPdb: 1401] [UniProtKB: Q6GMR7]
ChEMBL Inhibition of FAAH2 B 5 pIC50 >10000 nM IC50 ACS Med. Chem. Lett. (2012) 3: 823-827 [PMID:24900385]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]