JNJ40355003 [Ligand Id: 9050] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2164602 (JNJ-40355003) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| GtoPdb | - | - | 8.85 | pIC50 | 1.4 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-7 [PMID:24900385] |
| ChEMBL | Inhibition of human FAAH after 1 hr | B | 8.85 | pIC50 | 1.4 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-827 [PMID:24900385] |
| ChEMBL | Inhibition of human FAAH preincubated for 60 mins | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7357-7362 [PMID:23141911] |
| ChEMBL | Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation analysis | B | 8.85 | pIC50 | 1.4 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3109-3114 [PMID:27189675] |
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| GtoPdb | - | - | 7.48 | pIC50 | 33 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-7 [PMID:24900385] |
| ChEMBL | Inhibition of rat FAAH after 1 hr | B | 7.48 | pIC50 | 33 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-827 [PMID:24900385] |
| ChEMBL | Inhibition of rat FAAH preincubated for 60 mins | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 7357-7362 [PMID:23141911] |
| ChEMBL | Apparent inhibition of recombinant rat FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation analysis | B | 7.48 | pIC50 | 33 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3109-3114 [PMID:27189675] |
| Fatty acid amide hydrolase-2/Fatty-acid amide hydrolase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628475] [GtoPdb: 1401] [UniProtKB: Q6GMR7] | ||||||||
| ChEMBL | Inhibition of FAAH2 | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2012) 3: 823-827 [PMID:24900385] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
