cytarabine [Ligand Id: 4827] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL803 (Ara-cytidine, Depocyt, Alexan 100, Cytosar, Cytarabine, U-19920, NSC-287459, Cytosar-u, Depocyte, Tarabine Pfs, Arabinosyl cytosine, U-19,920, Alexan)
  • Enoyl-[acyl-carrier-protein] reductase [NADH] in Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) [ChEMBL: CHEMBL2150835] [UniProtKB: Q5NGQ3]
  • This target only has 0 pki data point
  • 0
1 CHEMBL803_lig_chart_1 Enoyl-[acyl-carrier-protein] reductase [NADH] Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
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  • MDM2 proto-oncogene/p53-binding protein Mdm-2 in Human [ChEMBL: CHEMBL5023] [GtoPdb: 3136] [UniProtKB: Q00987]
  • This target only has 0 pki data point
  • 0
2 CHEMBL803_lig_chart_2 p53-binding protein Mdm-2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Enoyl-[acyl-carrier-protein] reductase [NADH] in Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150835] [UniProtKB: Q5NGQ3]
ChEMBL Inhibition of C-terminal His6-tagged Francisella tularensis SCHU S4 FabI expressed in Escherichia coli BL21 (DE3) using CrCoA as substrate assessed as oxidation of NADH to NAD+ by fluorescence assay B 4.23 pIC50 59000 nM IC50 J. Med. Chem. (2013) 56: 5275-5287 [PMID:23815100]
MDM2 proto-oncogene/p53-binding protein Mdm-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5023] [GtoPdb: 3136] [UniProtKB: Q00987]
ChEMBL Inhibition of MDM2 (unknown origin) B 7.7 pIC50 20 nM IC50 Eur J Med Chem (2018) 159: 1-9 [PMID:30253242]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]