cytarabine [Ligand Id: 4827] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL803 (Alexan, Alexan 100, Arabinocytosine, Arabinosyl cytosine, Ara-c, Ara-cytidine, Aracytidine, Aracytin, Aracytine, Cytarabine, Cytarabine liposome, Cytarabinoside, Cytarabinum, Cytosar, Cytosar-u, Depocyt, Depocyte, NSC-287459, Spongocytidine, Tarabine Pfs, U-19,920, U-19920, U 19920a)
  • Enoyl-[acyl-carrier-protein] reductase [NADH] in Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) [ChEMBL: CHEMBL2150835] [UniProtKB: Q5NGQ3]
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  • MDM2 proto-oncogene/p53-binding protein Mdm-2 in Human [ChEMBL: CHEMBL5023] [GtoPdb: 3136] [UniProtKB: Q00987]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Enoyl-[acyl-carrier-protein] reductase [NADH] in Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150835] [UniProtKB: Q5NGQ3]
ChEMBL Inhibition of C-terminal His6-tagged Francisella tularensis SCHU S4 FabI expressed in Escherichia coli BL21 (DE3) using CrCoA as substrate assessed as oxidation of NADH to NAD+ by fluorescence assay B 4.23 pIC50 59000 nM IC50 J Med Chem (2013) 56: 5275-5287 [PMID:23815100]
MDM2 proto-oncogene/p53-binding protein Mdm-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5023] [GtoPdb: 3136] [UniProtKB: Q00987]
ChEMBL Inhibition of MDM2 (unknown origin) B 7.7 pIC50 20 nM IC50 Eur J Med Chem (2018) 159: 1-9 [PMID:30253242]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]