I-ABOPX [Ligand Id: 446] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL355370
  • Adenosine A1 receptor in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
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  • A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8]
  • A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
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  • A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL Displacement of [125-I]-labeled aminobenzyl adenosine binding to adenosine A1 receptor of bovine brain membranes B 7.43 pKd 37 nM Kd J. Med. Chem. (1988) 31: 745-751 [PMID:3351850]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Binding affinity towards adenosine A1 receptor in rat brain membrane(KD) B 9.1 pKd 0.8 nM Kd J. Med. Chem. (1988) 31: 752-756 [PMID:3351851]
ChEMBL Displacement of [3H]PIA from adenosine A1 receptors of rat brain membrane B 7.43 pKi 37 nM Ki J. Med. Chem. (1994) 37: 3373-3382 [PMID:7932565]
ChEMBL Binding affinity to adenosine A1 receptor of rat brain membranes without NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding B 7.43 pIC50 37 nM IC50 J. Med. Chem. (1988) 31: 745-751 [PMID:3351850]
ChEMBL Binding affinity to adenosine A1 receptor of rat brain membranes with 1 M NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding B 8.52 pIC50 3 nM IC50 J. Med. Chem. (1988) 31: 745-751 [PMID:3351850]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane B 6.15 pKi 700 nM Ki J. Med. Chem. (1994) 37: 3373-3382 [PMID:7932565]
A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8]
GtoPdb - - 7.7 pKi - - - Proc Natl Acad Sci USA (1993) 90: 10365-9 [PMID:8234299]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
ChEMBL Displacement of [125I]AB-MECA from membranes of CHO cells stably transfected with the rat adenosine A3 receptor cDNA B 5.93 pKi 1170 nM Ki J. Med. Chem. (1994) 37: 3373-3382 [PMID:7932565]
A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb - - 7.4 pKi - - - Mol Pharmacol (1999) 56: 705-13 [PMID:10496952]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]