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ChEMBL ligand: CHEMBL355370 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190] | ||||||||
ChEMBL | Displacement of [125-I]-labeled aminobenzyl adenosine binding to adenosine A1 receptor of bovine brain membranes | B | 7.43 | pKd | 37 | nM | Kd | J Med Chem (1988) 31: 745-751 [PMID:3351850] |
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
ChEMBL | Binding affinity towards adenosine A1 receptor in rat brain membrane(KD) | B | 9.1 | pKd | 0.8 | nM | Kd | J Med Chem (1988) 31: 752-756 [PMID:3351851] |
ChEMBL | Displacement of [3H]PIA from adenosine A1 receptors of rat brain membrane | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (1994) 37: 3373-3382 [PMID:7932565] |
ChEMBL | Binding affinity to adenosine A1 receptor of rat brain membranes without NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (1988) 31: 745-751 [PMID:3351850] |
ChEMBL | Binding affinity to adenosine A1 receptor of rat brain membranes with 1 M NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (1988) 31: 745-751 [PMID:3351850] |
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
ChEMBL | Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane | B | 6.15 | pKi | 700 | nM | Ki | J Med Chem (1994) 37: 3373-3382 [PMID:7932565] |
A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
GtoPdb | - | - | 7.7 | pKi | - | - | - | Proc Natl Acad Sci USA (1993) 90: 10365-9 [PMID:8234299] |
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
ChEMBL | Displacement of [125I]AB-MECA from membranes of CHO cells stably transfected with the rat adenosine A3 receptor cDNA | B | 5.93 | pKi | 1170 | nM | Ki | J Med Chem (1994) 37: 3373-3382 [PMID:7932565] |
A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
GtoPdb | - | - | 7.4 | pKi | - | - | - | Mol Pharmacol (1999) 56: 705-13 [PMID:10496952] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]