ChEMBL ligand: CHEMBL355370
Adenosine A1 receptor in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190] A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] There should be some charts here, you may need to enable JavaScript!
A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL	Displacement of [125-I]-labeled aminobenzyl adenosine binding to adenosine A1 receptor of bovine brain membranes	B	7.43	pKd	37	nM	Kd	J Med Chem (1988) 31: 745-751 [PMID:3351850]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Binding affinity towards adenosine A1 receptor in rat brain membrane(KD)	B	9.1	pKd	0.8	nM	Kd	J Med Chem (1988) 31: 752-756 [PMID:3351851]
ChEMBL	Displacement of [3H]PIA from adenosine A1 receptors of rat brain membrane	B	7.43	pKi	37	nM	Ki	J Med Chem (1994) 37: 3373-3382 [PMID:7932565]
ChEMBL	Binding affinity to adenosine A1 receptor of rat brain membranes without NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding	B	7.43	pIC50	37	nM	IC50	J Med Chem (1988) 31: 745-751 [PMID:3351850]
ChEMBL	Binding affinity to adenosine A1 receptor of rat brain membranes with 1 M NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding	B	8.52	pIC50	3	nM	IC50	J Med Chem (1988) 31: 745-751 [PMID:3351850]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL	Displacement of [3H]-CGS- 21680 from adenosine A2a receptors of rat striatal membrane	B	6.15	pKi	700	nM	Ki	J Med Chem (1994) 37: 3373-3382 [PMID:7932565]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
GtoPdb	-	-	7.7	pKi	-	-	-	Proc Natl Acad Sci USA (1993) 90: 10365-9 [PMID:8234299]
ChEMBL	Displacement of f [125I]ABA to human A3 adenosine receptor derived from CHO cell membrane assessed as inhibition constant	B	7.74	pKi	18	nM	Ki	J Med Chem (2021) 64: 7156-7178 [PMID:34019396]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
ChEMBL	Displacement of [125I]AB-MECA from membranes of CHO cells stably transfected with the rat adenosine A3 receptor cDNA	B	5.93	pKi	1170	nM	Ki	J Med Chem (1994) 37: 3373-3382 [PMID:7932565]
A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb	-	-	7.4	pKi	-	-	-	Mol Pharmacol (1999) 56: 705-13 [PMID:10496952]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]