JNK inhibitor 9l [Ligand Id: 9377] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL585951
  • mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
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  • mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
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  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Rat [ChEMBL: CHEMBL4092] [GtoPdb: 1498] [UniProtKB: P49187]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
GtoPdb - - 7 pIC50 99 nM IC50 J Med Chem (2010) 53: 419-31 [PMID:19947601]
ChEMBL Inhibition of JNK1 by time resolved fluorescence assay B 7 pIC50 99 nM IC50 J Med Chem (2010) 53: 419-431 [PMID:19947601]
ChEMBL Inhibition of JNK1 (unknown origin) by time-resolved fluorescence assay B 7 pIC50 99 nM IC50 J Med Chem (2015) 58: 72-95 [PMID:25415535]
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL Inhibition of JNK2 (unknown origin) by time-resolved fluorescence assay B 7 pIC50 99 nM IC50 J Med Chem (2015) 58: 72-95 [PMID:25415535]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Inhibition of JNK3 by time resolved fluorescence assay B 6.83 pIC50 148 nM IC50 J Med Chem (2010) 53: 419-431 [PMID:19947601]
ChEMBL Inhibition of JNK3 (unknown origin) by time-resolved fluorescence assay B 6.83 pIC50 148 nM IC50 J Med Chem (2015) 58: 72-95 [PMID:25415535]
GtoPdb - - 6.83 pIC50 148 nM IC50 J Med Chem (2010) 53: 419-31 [PMID:19947601]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4092] [GtoPdb: 1498] [UniProtKB: P49187]
ChEMBL Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells B 7.27 pIC50 54 nM IC50 J Med Chem (2015) 58: 72-95 [PMID:25415535]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]