JNK inhibitor 9l [Ligand Id: 9377] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL585951
  • mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
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  • mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
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  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Rat [ChEMBL: CHEMBL4092] [GtoPdb: 1498] [UniProtKB: P49187]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
GtoPdb - - 7 pIC50 99 nM IC50 J Med Chem (2010) 53: 419-31 [PMID:19947601]
ChEMBL Inhibition of JNK1 by time resolved fluorescence assay B 7 pIC50 99 nM IC50 J Med Chem (2010) 53: 419-431 [PMID:19947601]
ChEMBL Inhibition of JNK1 (unknown origin) by time-resolved fluorescence assay B 7 pIC50 99 nM IC50 J Med Chem (2015) 58: 72-95 [PMID:25415535]
mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984]
ChEMBL Inhibition of JNK2 (unknown origin) by time-resolved fluorescence assay B 7 pIC50 99 nM IC50 J Med Chem (2015) 58: 72-95 [PMID:25415535]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Inhibition of JNK3 by time resolved fluorescence assay B 6.83 pIC50 148 nM IC50 J Med Chem (2010) 53: 419-431 [PMID:19947601]
ChEMBL Inhibition of JNK3 (unknown origin) by time-resolved fluorescence assay B 6.83 pIC50 148 nM IC50 J Med Chem (2015) 58: 72-95 [PMID:25415535]
GtoPdb - - 6.83 pIC50 148 nM IC50 J Med Chem (2010) 53: 419-31 [PMID:19947601]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4092] [GtoPdb: 1498] [UniProtKB: P49187]
ChEMBL Inhibition of JNK3-mediated c-jun phosphorylation in rat INS1 cells B 7.27 pIC50 54 nM IC50 J Med Chem (2015) 58: 72-95 [PMID:25415535]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]