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ChEMBL ligand: CHEMBL7303 (NSC-56321) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
ChEMBL | Binding affinity to human cloned muscarinic M1 receptor expressed in CHO cells | B | 4.53 | pKi | 29512.09 | nM | Ki | Bioorg Med Chem (2008) 16: 3049-3058 [PMID:18182302] |
ChEMBL | Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M1 using [3H]QNB radioligand | B | 4.54 | pKi | 29000 | nM | Ki | J Med Chem (2003) 46: 2216-2226 [PMID:12747793] |
GtoPdb | - | - | 5.7 | pKi | - | - | - |
Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715]; Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]; Eur J Med Chem (2020) 204: 112623 [PMID:32717485] |
ChEMBL | Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M1 expressed in CHO cell membranes | B | 7.85 | pKi | 14 | nM | Ki | J Med Chem (2000) 43: 2514-2522 [PMID:10891110] |
ChEMBL | In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB) | B | 4.19 | pIC50 | 65000 | nM | IC50 | J Med Chem (1997) 40: 4265-4280 [PMID:9435896] |
ChEMBL | Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferens | F | 6.26 | pIC50 | 545 | nM | IC50 | J Med Chem (1992) 35: 4011-4019 [PMID:1433209] |
ChEMBL | Ability to displace [3H]oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells. | B | 6.94 | pIC50 | 115 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2855-2857 [PMID:11597415] |
ChEMBL | Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor | F | 5.25 | pEC50 | 5603 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 2897-2902 [PMID:9873644] |
ChEMBL | In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT) | B | 5.49 | pEC50 | 3200 | nM | EC50 | J Med Chem (1995) 38: 2188-2195 [PMID:7783150] |
M1 receptor/Muscarinic acetylcholine receptor M1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3733] [GtoPdb: 13] [UniProtKB: P12657] | ||||||||
ChEMBL | Binding affinity of [3H]-(R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the presence of 300 uM GTP-gamma-S | B | 8.26 | pKi | 5.45 | nM | Ki | J Med Chem (1997) 40: 1230-1246 [PMID:9111297] |
ChEMBL | Binding affinity (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma-S | B | 8.48 | pKi | 3.33 | nM | Ki | J Med Chem (1997) 40: 1230-1246 [PMID:9111297] |
ChEMBL | Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line | B | 4.57 | pEC50 | 27000 | nM | EC50 | J Med Chem (1997) 40: 1230-1246 [PMID:9111297] |
M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482] | ||||||||
ChEMBL | Displacement of [3H]QNB from muscarinic M1 receptor in Wistar rat brain cortex after 2 hrs by liquid scintillation counting | B | 4.06 | pKi | 88000 | nM | Ki | Bioorg Med Chem (2009) 17: 5526-5534 [PMID:19595599] |
ChEMBL | Displacement of [3H]Quinuclidinyl benzilate from muscarinic M1 receptor in Wistar rat cortex synaptosomal membrane | B | 4.07 | pKi | 86000 | nM | Ki | Bioorg Med Chem (2008) 16: 5157-5163 [PMID:18359231] |
ChEMBL | Displacement of [3H]QNB from muscarinic M1 receptor in Wistar rat brain cortex membrane after 2 hrs by liquid scintillation counting | B | 4.07 | pKi | 86000 | nM | Ki | Eur J Med Chem (2009) 44: 4848-4854 [PMID:19717214] |
GtoPdb | - | - | 5.3 | pKi | - | - | - | J Pharmacol Exp Ther (1989) 248: 661-70 [PMID:2537406] |
ChEMBL | Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 receptors (m1-QNBm1c2) | B | 4.92 | pIC50 | 11920 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 147-150 |
ChEMBL | Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue. | B | 5.76 | pIC50 | 1740 | nM | IC50 | J Med Chem (1992) 35: 15-27 [PMID:1732522] |
ChEMBL | Evaluated for inhibition of binding of [3H]pirenzepine to homogenized rat cerebral cortex membranes | B | 5.76 | pIC50 | 1737.8 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 501-504 |
ChEMBL | Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand. | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1995) 38: 3469-3481 [PMID:7658434] |
ChEMBL | In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]pirenzepine (Pz) as radioligand | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1992) 35: 2274-2283 [PMID:1613751] |
ChEMBL | Displacement of [3H]-Pz (pirenzepine) from the muscarinic receptor M1 of the rat hippocampus | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 809-814 |
ChEMBL | Displacement of [3H]pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1 | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1992) 35: 4011-4019 [PMID:1433209] |
ChEMBL | Inhibition of [3H]pirenzepine binding to rat brain membrane Muscarinic acetylcholine receptor M1 | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (1988) 31: 1312-1316 [PMID:3385727] |
ChEMBL | In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]oxotremorine-M (Oxo-M) as radioligand | B | 7.11 | pIC50 | 77 | nM | IC50 | J Med Chem (1992) 35: 2274-2283 [PMID:1613751] |
ChEMBL | Displacement of [3H]oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1 | B | 7.11 | pIC50 | 77 | nM | IC50 | J Med Chem (1992) 35: 4011-4019 [PMID:1433209] |
ChEMBL | Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand. | B | 7.11 | pIC50 | 77 | nM | IC50 | J Med Chem (1995) 38: 3469-3481 [PMID:7658434] |
ChEMBL | M1 agonist activity estimated by rat superior cervical ganglion depolarization | F | 6.66 | pEC50 | >=220 | nM | EC50 | J Med Chem (1994) 37: 4085-4099 [PMID:7990109] |
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
GtoPdb | - | - | 5.2 | pKi | - | - | - |
Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715]; Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]; Eur J Med Chem (2020) 204: 112623 [PMID:32717485] |
ChEMBL | Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cells | B | 5.61 | pKi | 2454.71 | nM | Ki | Bioorg Med Chem (2008) 16: 3049-3058 [PMID:18182302] |
ChEMBL | Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand | B | 5.62 | pKi | 2400 | nM | Ki | J Med Chem (2003) 46: 2216-2226 [PMID:12747793] |
ChEMBL | Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2000) 43: 2514-2522 [PMID:10891110] |
ChEMBL | The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (2000) 43: 2514-2522 [PMID:10891110] |
ChEMBL | Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2 | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (1998) 41: 2047-2055 [PMID:9622546] |
ChEMBL | Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2 | B | 5.35 | pIC50 | 4500 | nM | IC50 | J Med Chem (1998) 41: 109-116 [PMID:9438027] |
ChEMBL | In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2 | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (1997) 40: 4265-4280 [PMID:9435896] |
ChEMBL | Stimulation of cAMP in CHO cells expressing human m2 receptor | F | 5 | pEC50 | 10000 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 2897-2902 [PMID:9873644] |
ChEMBL | In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate | B | 7.08 | pEC50 | 83 | nM | EC50 | J Med Chem (1994) 37: 4085-4099 [PMID:7990109] |
ChEMBL | In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT). | B | 7.6 | pEC50 | 25 | nM | EC50 | J Med Chem (1995) 38: 2188-2195 [PMID:7783150] |
M2 receptor/Muscarinic acetylcholine receptor M2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980] | ||||||||
ChEMBL | Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes | B | 7.4 | pKi | 40 | nM | Ki | J Med Chem (1998) 41: 2047-2055 [PMID:9622546] |
ChEMBL | Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (1988) 31: 1312-1316 [PMID:3385727] |
ChEMBL | Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart) | B | 5.04 | pIC50 | 9150 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 147-150 |
ChEMBL | Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (1988) 31: 1312-1316 [PMID:3385727] |
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
ChEMBL | Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M3 using [3H]QNB radioligand | B | 4.37 | pKi | 43000 | nM | Ki | J Med Chem (2003) 46: 2216-2226 [PMID:12747793] |
ChEMBL | Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M3 | B | 5.24 | pKi | 5700 | nM | Ki | J Med Chem (1998) 41: 2047-2055 [PMID:9622546] |
GtoPdb | - | - | 5.4 | pKi | - | - | - |
Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715]; Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]; Eur J Med Chem (2020) 204: 112623 [PMID:32717485] |
ChEMBL | Compound was evaluated for its ability to displace [3H]N-methylscopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M3 | B | 4.24 | pIC50 | 58000 | nM | IC50 | J Med Chem (1998) 41: 109-116 [PMID:9438027] |
ChEMBL | In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3 | B | 4.96 | pIC50 | 11000 | nM | IC50 | J Med Chem (1997) 40: 4265-4280 [PMID:9435896] |
ChEMBL | In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT) | B | 6.47 | pEC50 | 340 | nM | EC50 | J Med Chem (1995) 38: 2188-2195 [PMID:7783150] |
ChEMBL | Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine | B | 7 | pEC50 | 100 | nM | EC50 | J Med Chem (1986) 29: 1004-1009 [PMID:3712371] |
M3 receptor/Muscarinic acetylcholine receptor M3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5105] [GtoPdb: 15] [UniProtKB: Q9ERZ3] | ||||||||
ChEMBL | Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell line | F | 4.92 | pEC50 | 12000 | nM | EC50 | J Med Chem (1997) 40: 1230-1246 [PMID:9111297] |
M3 receptor/Muscarinic acetylcholine receptor M3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483] | ||||||||
ChEMBL | Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M3 in rat cerebral cortical membranes | B | 5.24 | pKi | 5700 | nM | Ki | J Med Chem (1998) 41: 2047-2055 [PMID:9622546] |
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
ChEMBL | Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M4 using [3H]QNB radioligand | B | 4.22 | pKi | 60000 | nM | Ki | J Med Chem (2003) 46: 2216-2226 [PMID:12747793] |
GtoPdb | - | - | 5.5 | pKi | - | - | - |
Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715]; Mol Pharmacol (1997) 52: 172-9 [PMID:9224827]; Eur J Med Chem (2020) 204: 112623 [PMID:32717485] |
ChEMBL | Inhibition of [3H]- quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M4 expressed in CHO cell membranes | B | 5.62 | pKi | 2400 | nM | Ki | J Med Chem (2000) 43: 2514-2522 [PMID:10891110] |
ChEMBL | Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M4 | B | 5.62 | pKi | 2400 | nM | Ki | J Med Chem (1998) 41: 2047-2055 [PMID:9622546] |
ChEMBL | Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranes | B | 7.59 | pKi | 26 | nM | Ki | J Med Chem (2000) 43: 2514-2522 [PMID:10891110] |
ChEMBL | Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M4 | B | 4.32 | pIC50 | 47500 | nM | IC50 | J Med Chem (1998) 41: 109-116 [PMID:9438027] |
ChEMBL | In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M4 | B | 4.87 | pIC50 | 13500 | nM | IC50 | J Med Chem (1997) 40: 4265-4280 [PMID:9435896] |
ChEMBL | In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M4 determined by receptor selection and amplification technology (R-SAT) | B | 6.89 | pEC50 | 130 | nM | EC50 | J Med Chem (1995) 38: 2188-2195 [PMID:7783150] |
M4 receptor/Muscarinic acetylcholine receptor M4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL317] [GtoPdb: 16] [UniProtKB: P08485] | ||||||||
ChEMBL | Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M4 in rat cerebral cortical membranes | B | 5.62 | pKi | 2400 | nM | Ki | J Med Chem (1998) 41: 2047-2055 [PMID:9622546] |
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
ChEMBL | Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cells | B | 4.25 | pKi | 56234.13 | nM | Ki | Bioorg Med Chem (2008) 16: 3049-3058 [PMID:18182302] |
ChEMBL | Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M5 using [3H]QNB radioligand | B | 4.25 | pKi | 56000 | nM | Ki | J Med Chem (2003) 46: 2216-2226 [PMID:12747793] |
ChEMBL | Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5 | B | 4.2 | pIC50 | 62500 | nM | IC50 | J Med Chem (1998) 41: 109-116 [PMID:9438027] |
ChEMBL | In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT) | B | 6.22 | pEC50 | 600 | nM | EC50 | J Med Chem (1995) 38: 2188-2195 [PMID:7783150] |
nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor α6 subunit/nicotinic acetylcholine receptor α9 subunit/nicotinic acetylcholine receptor α7 subunit/nicotinic acetylcholine receptor α10 subunit/Neuronal acetylcholine receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094110] [GtoPdb: 464, 465, 463, 472, 473, 474, 466, 467, 469, 468, 470] [UniProtKB: P04757, P09483, P12389, P12390, P12391, P12392, P20420, P43143, P43144, Q05941, Q9JLB5] | ||||||||
ChEMBL | Binding affinity for Nicotinic acetylcholine receptor site in rat cortex was determined using [3H]MCC as radioligand | B | 6.65 | pKi | 224 | nM | Ki | Bioorg Med Chem Lett (1994) 4: 573-578 |
nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390] | ||||||||
ChEMBL | The compound was evaluated for percentage inhibition of binding of [3H]- nicotine to Nicotinic acetylcholine receptor alpha4-beta2 in Rat Cerebral Cortical Membranes | B | 6.57 | pKi | 270 | nM | Ki | J Med Chem (1998) 41: 2047-2055 [PMID:9622546] |
ChEMBL | Inhibition of binding of [3H]nicotine to Nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortical membranes at 100 uM concentration | B | 6.57 | pKi | 270 | nM | Ki | J Med Chem (1998) 41: 2047-2055 [PMID:9622546] |
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] | ||||||||
ChEMBL | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in guinea pig ventricular myocytes | F | 4.47 | pIC50 | 33730 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]