arecoline [Ligand Id: 296] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL7303 (NSC-56321)
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Mouse [ChEMBL: CHEMBL3733] [GtoPdb: 13] [UniProtKB: P12657]
  • M1 receptor/Muscarinic acetylcholine receptor M1 in Rat [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
There should be some charts here, you may need to enable JavaScript!
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
  • M2 receptor/Muscarinic acetylcholine receptor M2 in Rat [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980]
There should be some charts here, you may need to enable JavaScript!
  • M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
  • M3 receptor/Muscarinic acetylcholine receptor M3 in Mouse [ChEMBL: CHEMBL5105] [GtoPdb: 15] [UniProtKB: Q9ERZ3]
  • M3 receptor/Muscarinic acetylcholine receptor M3 in Rat [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483]
There should be some charts here, you may need to enable JavaScript!
  • M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
  • M4 receptor/Muscarinic acetylcholine receptor M4 in Rat [ChEMBL: CHEMBL317] [GtoPdb: 16] [UniProtKB: P08485]
There should be some charts here, you may need to enable JavaScript!
  • M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
There should be some charts here, you may need to enable JavaScript!
  • nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor α6 subunit/nicotinic acetylcholine receptor α9 subunit/nicotinic acetylcholine receptor α7 subunit/nicotinic acetylcholine receptor α10 subunit/Neuronal acetylcholine receptor in Rat [ChEMBL: CHEMBL2094110] [GtoPdb: 464465463472473474466467469468470] [UniProtKB: P04757P09483P12389P12390P12391P12392P20420P43143P43144Q05941Q9JLB5]
There should be some charts here, you may need to enable JavaScript!
  • nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat [ChEMBL: CHEMBL1907596] [GtoPdb: 465472] [UniProtKB: P09483P12390]
There should be some charts here, you may need to enable JavaScript!
  • Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig [ChEMBL: CHEMBL2366456] [UniProtKB: O35505]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL Binding affinity to human cloned muscarinic M1 receptor expressed in CHO cells B 4.53 pKi 29512.09 nM Ki Bioorg Med Chem (2008) 16: 3049-3058 [PMID:18182302]
ChEMBL Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M1 using [3H]QNB radioligand B 4.54 pKi 29000 nM Ki J Med Chem (2003) 46: 2216-2226 [PMID:12747793]
GtoPdb - - 5.7 pKi - - - Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715];
Mol Pharmacol (1997) 52: 172-9 [PMID:9224827];
Eur J Med Chem (2020) 204: 112623 [PMID:32717485]
ChEMBL Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M1 expressed in CHO cell membranes B 7.85 pKi 14 nM Ki J Med Chem (2000) 43: 2514-2522 [PMID:10891110]
ChEMBL In vitro affinity against human Muscarinic acetylcholine receptor M1 using quinuclidynyl benzylate (QNB) B 4.19 pIC50 65000 nM IC50 J Med Chem (1997) 40: 4265-4280 [PMID:9435896]
ChEMBL Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferens F 6.26 pIC50 545 nM IC50 J Med Chem (1992) 35: 4011-4019 [PMID:1433209]
ChEMBL Ability to displace [3H]oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells. B 6.94 pIC50 115 nM IC50 Bioorg Med Chem Lett (2001) 11: 2855-2857 [PMID:11597415]
ChEMBL Stimulation of phosphoinositide hydrolysis in A9L cells expressing human m1 receptor F 5.25 pEC50 5603 nM EC50 Bioorg Med Chem Lett (1998) 8: 2897-2902 [PMID:9873644]
ChEMBL In Vitro evaluation activity at the cloned Human Muscarinic acetylcholine receptor M1 determined by receptor selection and amplification technology (R-SAT) B 5.49 pEC50 3200 nM EC50 J Med Chem (1995) 38: 2188-2195 [PMID:7783150]
M1 receptor/Muscarinic acetylcholine receptor M1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3733] [GtoPdb: 13] [UniProtKB: P12657]
ChEMBL Binding affinity of [3H]-(R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the presence of 300 uM GTP-gamma-S B 8.26 pKi 5.45 nM Ki J Med Chem (1997) 40: 1230-1246 [PMID:9111297]
ChEMBL Binding affinity (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma-S B 8.48 pKi 3.33 nM Ki J Med Chem (1997) 40: 1230-1246 [PMID:9111297]
ChEMBL Tested against Muscarinic acetylcholine receptor M1 expressed in A9 L cell line B 4.57 pEC50 27000 nM EC50 J Med Chem (1997) 40: 1230-1246 [PMID:9111297]
M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482]
ChEMBL Displacement of [3H]QNB from muscarinic M1 receptor in Wistar rat brain cortex after 2 hrs by liquid scintillation counting B 4.06 pKi 88000 nM Ki Bioorg Med Chem (2009) 17: 5526-5534 [PMID:19595599]
ChEMBL Displacement of [3H]Quinuclidinyl benzilate from muscarinic M1 receptor in Wistar rat cortex synaptosomal membrane B 4.07 pKi 86000 nM Ki Bioorg Med Chem (2008) 16: 5157-5163 [PMID:18359231]
ChEMBL Displacement of [3H]QNB from muscarinic M1 receptor in Wistar rat brain cortex membrane after 2 hrs by liquid scintillation counting B 4.07 pKi 86000 nM Ki Eur J Med Chem (2009) 44: 4848-4854 [PMID:19717214]
GtoPdb - - 5.3 pKi - - - J Pharmacol Exp Ther (1989) 248: 661-70 [PMID:2537406]
ChEMBL Compound was evaluated for the displacement of the muscarinic QNB in a genetically transformed rat cell line (m1c2) transfected with cloned m1 receptors (m1-QNBm1c2) B 4.92 pIC50 11920 nM IC50 Bioorg Med Chem Lett (1991) 1: 147-150
ChEMBL Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue. B 5.76 pIC50 1740 nM IC50 J Med Chem (1992) 35: 15-27 [PMID:1732522]
ChEMBL Evaluated for inhibition of binding of [3H]pirenzepine to homogenized rat cerebral cortex membranes B 5.76 pIC50 1737.8 nM IC50 Bioorg Med Chem Lett (1992) 2: 501-504
ChEMBL Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand. B 5.89 pIC50 1300 nM IC50 J Med Chem (1995) 38: 3469-3481 [PMID:7658434]
ChEMBL In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]pirenzepine (Pz) as radioligand B 5.89 pIC50 1300 nM IC50 J Med Chem (1992) 35: 2274-2283 [PMID:1613751]
ChEMBL Displacement of [3H]-Pz (pirenzepine) from the muscarinic receptor M1 of the rat hippocampus B 5.89 pIC50 1300 nM IC50 Bioorg Med Chem Lett (1992) 2: 809-814
ChEMBL Displacement of [3H]pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1 B 5.89 pIC50 1300 nM IC50 J Med Chem (1992) 35: 4011-4019 [PMID:1433209]
ChEMBL Inhibition of [3H]pirenzepine binding to rat brain membrane Muscarinic acetylcholine receptor M1 B 5.96 pIC50 1100 nM IC50 J Med Chem (1988) 31: 1312-1316 [PMID:3385727]
ChEMBL In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]oxotremorine-M (Oxo-M) as radioligand B 7.11 pIC50 77 nM IC50 J Med Chem (1992) 35: 2274-2283 [PMID:1613751]
ChEMBL Displacement of [3H]oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1 B 7.11 pIC50 77 nM IC50 J Med Chem (1992) 35: 4011-4019 [PMID:1433209]
ChEMBL Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand. B 7.11 pIC50 77 nM IC50 J Med Chem (1995) 38: 3469-3481 [PMID:7658434]
ChEMBL M1 agonist activity estimated by rat superior cervical ganglion depolarization F 6.66 pEC50 >=220 nM EC50 J Med Chem (1994) 37: 4085-4099 [PMID:7990109]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 5.2 pKi - - - Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715];
Mol Pharmacol (1997) 52: 172-9 [PMID:9224827];
Eur J Med Chem (2020) 204: 112623 [PMID:32717485]
ChEMBL Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cells B 5.61 pKi 2454.71 nM Ki Bioorg Med Chem (2008) 16: 3049-3058 [PMID:18182302]
ChEMBL Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligand B 5.62 pKi 2400 nM Ki J Med Chem (2003) 46: 2216-2226 [PMID:12747793]
ChEMBL Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane B 7.4 pKi 40 nM Ki J Med Chem (2000) 43: 2514-2522 [PMID:10891110]
ChEMBL The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells B 7.4 pKi 40 nM Ki J Med Chem (2000) 43: 2514-2522 [PMID:10891110]
ChEMBL Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2 B 7.4 pKi 40 nM Ki J Med Chem (1998) 41: 2047-2055 [PMID:9622546]
ChEMBL Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M2 B 5.35 pIC50 4500 nM IC50 J Med Chem (1998) 41: 109-116 [PMID:9438027]
ChEMBL In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2 B 5.74 pIC50 1800 nM IC50 J Med Chem (1997) 40: 4265-4280 [PMID:9435896]
ChEMBL Stimulation of cAMP in CHO cells expressing human m2 receptor F 5 pEC50 10000 nM EC50 Bioorg Med Chem Lett (1998) 8: 2897-2902 [PMID:9873644]
ChEMBL In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate B 7.08 pEC50 83 nM EC50 J Med Chem (1994) 37: 4085-4099 [PMID:7990109]
ChEMBL In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT). B 7.6 pEC50 25 nM EC50 J Med Chem (1995) 38: 2188-2195 [PMID:7783150]
M2 receptor/Muscarinic acetylcholine receptor M2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980]
ChEMBL Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes B 7.4 pKi 40 nM Ki J Med Chem (1998) 41: 2047-2055 [PMID:9622546]
ChEMBL Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 in rat brain membrane B 4.96 pIC50 11000 nM IC50 J Med Chem (1988) 31: 1312-1316 [PMID:3385727]
ChEMBL Compound was evaluated for the displacement of the muscarinic QNB in rat heart homogenate containing the pharmacologic M2 receptor (M2-QNB heart) B 5.04 pIC50 9150 nM IC50 Bioorg Med Chem Lett (1991) 1: 147-150
ChEMBL Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heart B 6.23 pIC50 590 nM IC50 J Med Chem (1988) 31: 1312-1316 [PMID:3385727]
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M3 using [3H]QNB radioligand B 4.37 pKi 43000 nM Ki J Med Chem (2003) 46: 2216-2226 [PMID:12747793]
ChEMBL Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M3 B 5.24 pKi 5700 nM Ki J Med Chem (1998) 41: 2047-2055 [PMID:9622546]
GtoPdb - - 5.4 pKi - - - Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715];
Mol Pharmacol (1997) 52: 172-9 [PMID:9224827];
Eur J Med Chem (2020) 204: 112623 [PMID:32717485]
ChEMBL Compound was evaluated for its ability to displace [3H]N-methylscopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M3 B 4.24 pIC50 58000 nM IC50 J Med Chem (1998) 41: 109-116 [PMID:9438027]
ChEMBL In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M3 B 4.96 pIC50 11000 nM IC50 J Med Chem (1997) 40: 4265-4280 [PMID:9435896]
ChEMBL In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT) B 6.47 pEC50 340 nM EC50 J Med Chem (1995) 38: 2188-2195 [PMID:7783150]
ChEMBL Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine B 7 pEC50 100 nM EC50 J Med Chem (1986) 29: 1004-1009 [PMID:3712371]
M3 receptor/Muscarinic acetylcholine receptor M3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5105] [GtoPdb: 15] [UniProtKB: Q9ERZ3]
ChEMBL Tested against Muscarinic acetylcholine receptor M3 expressed in A9 L cell line F 4.92 pEC50 12000 nM EC50 J Med Chem (1997) 40: 1230-1246 [PMID:9111297]
M3 receptor/Muscarinic acetylcholine receptor M3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483]
ChEMBL Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M3 in rat cerebral cortical membranes B 5.24 pKi 5700 nM Ki J Med Chem (1998) 41: 2047-2055 [PMID:9622546]
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M4 using [3H]QNB radioligand B 4.22 pKi 60000 nM Ki J Med Chem (2003) 46: 2216-2226 [PMID:12747793]
GtoPdb - - 5.5 pKi - - - Br J Pharmacol (1995) 114: 1241-9 [PMID:7620715];
Mol Pharmacol (1997) 52: 172-9 [PMID:9224827];
Eur J Med Chem (2020) 204: 112623 [PMID:32717485]
ChEMBL Inhibition of [3H]- quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M4 expressed in CHO cell membranes B 5.62 pKi 2400 nM Ki J Med Chem (2000) 43: 2514-2522 [PMID:10891110]
ChEMBL Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M4 B 5.62 pKi 2400 nM Ki J Med Chem (1998) 41: 2047-2055 [PMID:9622546]
ChEMBL Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranes B 7.59 pKi 26 nM Ki J Med Chem (2000) 43: 2514-2522 [PMID:10891110]
ChEMBL Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]-NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M4 B 4.32 pIC50 47500 nM IC50 J Med Chem (1998) 41: 109-116 [PMID:9438027]
ChEMBL In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M4 B 4.87 pIC50 13500 nM IC50 J Med Chem (1997) 40: 4265-4280 [PMID:9435896]
ChEMBL In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M4 determined by receptor selection and amplification technology (R-SAT) B 6.89 pEC50 130 nM EC50 J Med Chem (1995) 38: 2188-2195 [PMID:7783150]
M4 receptor/Muscarinic acetylcholine receptor M4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL317] [GtoPdb: 16] [UniProtKB: P08485]
ChEMBL Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M4 in rat cerebral cortical membranes B 5.62 pKi 2400 nM Ki J Med Chem (1998) 41: 2047-2055 [PMID:9622546]
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL Binding affinity to human cloned muscarinic M5 receptor expressed in CHO cells B 4.25 pKi 56234.13 nM Ki Bioorg Med Chem (2008) 16: 3049-3058 [PMID:18182302]
ChEMBL Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M5 using [3H]QNB radioligand B 4.25 pKi 56000 nM Ki J Med Chem (2003) 46: 2216-2226 [PMID:12747793]
ChEMBL Compound was evaluated for its ability to displace [3H]- N-methyl-scopolamine ([3H]NMS) binding to cloned CHO cell lines expressing Muscarinic acetylcholine receptor M5 B 4.2 pIC50 62500 nM IC50 J Med Chem (1998) 41: 109-116 [PMID:9438027]
ChEMBL In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT) B 6.22 pEC50 600 nM EC50 J Med Chem (1995) 38: 2188-2195 [PMID:7783150]
nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor α2 subunit/nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor β3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α5 subunit/nicotinic acetylcholine receptor α6 subunit/nicotinic acetylcholine receptor α9 subunit/nicotinic acetylcholine receptor α7 subunit/nicotinic acetylcholine receptor α10 subunit/Neuronal acetylcholine receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094110] [GtoPdb: 464465463472473474466467469468470] [UniProtKB: P04757P09483P12389P12390P12391P12392P20420P43143P43144Q05941Q9JLB5]
ChEMBL Binding affinity for Nicotinic acetylcholine receptor site in rat cortex was determined using [3H]MCC as radioligand B 6.65 pKi 224 nM Ki Bioorg Med Chem Lett (1994) 4: 573-578
nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907596] [GtoPdb: 465472] [UniProtKB: P09483P12390]
ChEMBL The compound was evaluated for percentage inhibition of binding of [3H]- nicotine to Nicotinic acetylcholine receptor alpha4-beta2 in Rat Cerebral Cortical Membranes B 6.57 pKi 270 nM Ki J Med Chem (1998) 41: 2047-2055 [PMID:9622546]
ChEMBL Inhibition of binding of [3H]nicotine to Nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortical membranes at 100 uM concentration B 6.57 pKi 270 nM Ki J Med Chem (1998) 41: 2047-2055 [PMID:9622546]
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505]
ChEMBL Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in guinea pig ventricular myocytes F 4.47 pIC50 33730 nM IC50 IC50 data for the L-type calcium channel extracted from a set of literature articles

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]