lestaurtinib [Ligand Id: 5672] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL603469 (A-154475, A-154475.0, CEP-701, KT-555, KT-5555, KT5555, Lestaurtinib, SP-924, SP924, SPM-924) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 26S proteasome regulatory subunit 6B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831205] [UniProtKB: P43686] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| 3-phosphoinositide dependent protein kinase 1/3-phosphoinositide-dependent protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530] | ||||||||
| ChEMBL | Binding affinity to PDPK1 | B | 8.47 | pKd | 3.4 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PDPK1 kinase domain | B | 8.47 | pKd | 3.4 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase AMP-activated catalytic subunit alpha 1/5`-AMP-activated protein kinase catalytic subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.08 | pKd | 840 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to AMPK-alpha1 | B | 7.6 | pKd | 25 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AMPK-alpha1 kinase domain | B | 7.6 | pKd | 25 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase AMP-activated catalytic subunit alpha 2/5`-AMP-activated protein kinase catalytic subunit alpha-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646] | ||||||||
| ChEMBL | Binding affinity to AMPK-alpha2 | B | 7.25 | pKd | 56 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AMPK-alpha2 kinase domain | B | 7.25 | pKd | 56 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase AMP-activated non-catalytic subunit gamma 1/5`-AMP-activated protein kinase subunit gamma-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2393] [GtoPdb: 1545] [UniProtKB: P54619] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.05 | pKd | 885 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase AMP-activated non-catalytic subunit gamma 2/5`-AMP-activated protein kinase subunit gamma-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2453] [GtoPdb: 1546] [UniProtKB: Q9UGJ0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.05 | pKd | 890 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| aarF domain containing kinase 1/AarF domain-containing protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105885] [GtoPdb: 1925] [UniProtKB: Q86TW2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Actin-related protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6090] [UniProtKB: P61160] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Actin-related protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105857] [UniProtKB: P61158] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| tyrosine kinase non receptor 2/Activated CDC42 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.19 | pKd | 64 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TNK2 kinase domain | B | 8.18 | pKd | 6.6 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.71 | pKd | 1949 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ACVR1 | B | 7.12 | pKd | 75 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVR1 kinase domain | B | 7.12 | pKd | 75 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.18 | pKd | 660 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ACVR1B | B | 7.07 | pKd | 86 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVR1B kinase domain | B | 7.07 | pKd | 86 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| activin A receptor type IL/Activin receptor type-1-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023] | ||||||||
| ChEMBL | Binding affinity to ACVRL1 | B | 5.66 | pKd | 2200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVRL1 kinase domain | B | 5.66 | pKd | 2200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| activin A receptor type 2A/Activin receptor type-2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037] | ||||||||
| ChEMBL | Binding affinity to ACVR2A | B | 5.6 | pKd | 2500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVR2A kinase domain | B | 5.6 | pKd | 2500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| activin A receptor type 2B/Activin receptor type-2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ACVR2B | B | 5.42 | pKd | 3800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVR2B kinase domain | B | 5.42 | pKd | 3800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Acyl-CoA dehydrogenase family member 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105816] [UniProtKB: Q6JQN1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Acyl-CoA dehydrogenase family member 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105707] [UniProtKB: Q709F0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Adenine phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105819] [UniProtKB: P07741] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Adenylate kinase 2, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4938] [UniProtKB: P54819] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Mitochondrial adenine nucleotide translocator 2/ADP/ATP translocase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3709670] [GtoPdb: 1063] [UniProtKB: P05141] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Mitochondrial adenine nucleotide translocator 3/ADP/ATP translocase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105854] [GtoPdb: 1064] [UniProtKB: P12236] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
| ChEMBL | Binding affinity to ALK | B | 7.15 | pKd | 71 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ALK kinase domain | B | 7.15 | pKd | 71 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TEK receptor tyrosine kinase/Angiopoietin-1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] | ||||||||
| ChEMBL | Binding affinity to TIE2 | B | 6.2 | pKd | 630 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TIE2 kinase domain | B | 6.2 | pKd | 630 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2] | ||||||||
| ChEMBL | Binding affinity to ANKK1 | B | 7.49 | pKd | 32 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ANKK1 kinase domain | B | 7.49 | pKd | 32 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| AP2 associated kinase 1/AP2-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.18 | pKd | 66 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to AAK1 | B | 8.51 | pKd | 3.1 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AAK1 kinase domain | B | 8.51 | pKd | 3.1 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ATP-dependent 6-phosphofructokinase, platelet type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2972] [UniProtKB: Q01813] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ATP-dependent RNA helicase DDX1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010634] [UniProtKB: Q92499] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ATP-dependent RNA helicase DDX3X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5553] [UniProtKB: O00571] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ATP-dependent RNA helicase DDX42 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105782] [UniProtKB: Q86XP3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ATP-dependent RNA helicase DHX30 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105814] [UniProtKB: Q7L2E3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| coenzyme Q8A/Atypical kinase COQ8A, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ADCK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ADCK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| coenzyme Q8B/Atypical kinase COQ8B, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53] | ||||||||
| ChEMBL | Binding affinity to ADCK4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ADCK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| aurora kinase A/Aurora kinase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.6 | pKd | 25 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to AURKA | B | 7.8 | pKd | 16 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AURKA kinase domain | B | 7.8 | pKd | 16 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| aurora kinase B/Aurora kinase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.88 | pKd | 131 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to AURKB | B | 7.8 | pKd | 16 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AURKB kinase domain | B | 7.8 | pKd | 16 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| aurora kinase C/Aurora kinase C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9] | ||||||||
| ChEMBL | Binding affinity to AURKC | B | 8.39 | pKd | 4.1 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AURKC kinase domain | B | 8.39 | pKd | 4.1 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| neurotrophic receptor tyrosine kinase 2/BDNF/NT-3 growth factors receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
| ChEMBL | Binding affinity to TRKB | B | 7.85 | pKd | 14 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TRKB kinase domain | B | 7.85 | pKd | 14 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| beta adrenergic receptor kinase 1/Beta-adrenergic receptor kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5922] [UniProtKB: P22234] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| BMP2 inducible kinase/BMP-2-inducible protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.67 | pKd | 214 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to BIKE | B | 7.8 | pKd | 16 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BIKE kinase domain | B | 7.8 | pKd | 16 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to BMPR1A | B | 6.02 | pKd | 950 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BMPR1A kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to BMPR1B | B | 7.24 | pKd | 57 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BMPR1B kinase domain | B | 7.24 | pKd | 57 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to BMPR2 | B | 5.82 | pKd | 1500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BMPR2 kinase domain | B | 5.82 | pKd | 1500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to recombinant BMPR2 (unknown origin) assessed as dissociation constant by DSF assay | B | 5.82 | pKd | 1500 | nM | Kd | ACS Med Chem Lett (2023) 14: 833-840 [PMID:37312836] |
| BCR activator of RhoGEF and GTPase/Breakpoint cluster region protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5146] [GtoPdb: 2755] [UniProtKB: P11274] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| calcium/calmodulin dependent protein kinase kinase 1/Calcium/calmodulin-dependent protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9] | ||||||||
| ChEMBL | Binding affinity to CAMKK1 | B | 7.64 | pKd | 23 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMKK1 kinase domain | B | 7.64 | pKd | 23 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase kinase 2/Calcium/calmodulin-dependent protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.86 | pKd | 1381 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CAMKK2 | B | 7.82 | pKd | 15 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMKK2 kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase I/Calcium/calmodulin-dependent protein kinase type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012] | ||||||||
| ChEMBL | Binding affinity to CAMK1 | B | 6.89 | pKd | 130 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK1 kinase domain | B | 6.89 | pKd | 130 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase ID/Calcium/calmodulin-dependent protein kinase type 1D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85] | ||||||||
| ChEMBL | Binding affinity to CAMK1D | B | 7.33 | pKd | 47 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK1D kinase domain | B | 7.33 | pKd | 47 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase IG/Calcium/calmodulin-dependent protein kinase type 1G in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5] | ||||||||
| ChEMBL | Binding constant for CAMK1G kinase domain | B | 6.33 | pKd | 470 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin-dependent protein kinase II alpha subunit/Calcium/calmodulin-dependent protein kinase type II subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7] | ||||||||
| ChEMBL | Binding affinity to CAMK2A | B | 8 | pKd | 10 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK2A kinase domain | B | 8 | pKd | 10 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin-dependent protein kinase II beta subunit/Calcium/calmodulin-dependent protein kinase type II subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554] | ||||||||
| ChEMBL | Binding affinity to CAMK2B | B | 7.23 | pKd | 59 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK2B kinase domain | B | 7.23 | pKd | 59 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin-dependent protein kinase II delta subunit/Calcium/calmodulin-dependent protein kinase type II subunit delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.48 | pKd | 332 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CAMK2D | B | 8.06 | pKd | 8.8 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK2D kinase domain | B | 8.06 | pKd | 8.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin-dependent protein kinase II gamma subunit/Calcium/calmodulin-dependent protein kinase type II subunit gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555] | ||||||||
| ChEMBL | Binding affinity to CAMK1G | B | 6.33 | pKd | 470 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.51 | pKd | 306 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CAMK2G | B | 7.59 | pKd | 26 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK2G kinase domain | B | 7.59 | pKd | 26 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase IV/Calcium/calmodulin-dependent protein kinase type IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CAMK4 | B | 5.52 | pKd | 3000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK4 kinase domain | B | 5.52 | pKd | 3000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Calcium-dependent protein kinase 1 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908387] [UniProtKB: P62344] | ||||||||
| ChEMBL | Binding constant for PFCDPK1(P.falciparum) kinase domain | B | 8.25 | pKd | 5.6 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase catalytic subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PKAC-alpha kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase catalytic subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PKAC-beta | B | 6.8 | pKd | 160 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PKAC-beta kinase domain | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase X-linked/cAMP-dependent protein kinase catalytic subunit PRKX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.89 | pKd | 1282 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PRKX | B | 7.38 | pKd | 42 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKX kinase domain | B | 7.38 | pKd | 42 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase, cAMP-dependent, regulatory, type II, alpha subunit/cAMP-dependent protein kinase type II-alpha regulatory subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2221] [GtoPdb: 1474] [UniProtKB: P13861] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| casein kinase 1 alpha 1/Casein kinase I isoform alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CSNK1A1L | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1A1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752] | ||||||||
| ChEMBL | Binding constant for CSNK1A1L kinase domain | B | 5.15 | pKd | 7100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 delta/Casein kinase I isoform delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CSNK1D | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1D kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 epsilon/Casein kinase I isoform epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CSNK1E | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1E kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 gamma 1/Casein kinase I isoform gamma-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CSNK1G1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1G1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 gamma 2/Casein kinase I isoform gamma-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CSNK1G2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1G2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CSNK1G3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1G3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
| ChEMBL | Binding constant for CSNK2A1 kinase domain | B | 5.59 | pKd | 2600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to CSNK2A1 | B | 7.16 | pKd | 69 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| casein kinase 2, alpha prime polypeptide subunit/Casein kinase II subunit alpha` in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CSNK2A2 kinase domain | B | 6.01 | pKd | 970 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to CSNK2A2 | B | 6.74 | pKd | 180 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PRKG1 | B | 6.43 | pKd | 370 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKG1 kinase domain | B | 6.43 | pKd | 370 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237] | ||||||||
| ChEMBL | Binding affinity to PRKG2 | B | 7.6 | pKd | 25 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKG2 kinase domain | B | 7.6 | pKd | 25 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Choline-phosphate cytidylyltransferase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105855] [UniProtKB: P49585] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Chromodomain-helicase-DNA-binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105742] [UniProtKB: Q14839] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CIT | B | 7.07 | pKd | 85 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CIT kinase domain | B | 7.07 | pKd | 85 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 10/Cyclin-dependent kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795191] [GtoPdb: 1962] [UniProtKB: Q15131] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 11A/Cyclin-dependent kinase 11A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88] | ||||||||
| ChEMBL | Binding affinity to CDC2L2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDC2L2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 11B/Cyclin-dependent kinase 11B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127] | ||||||||
| ChEMBL | Binding affinity to CDC2L1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDC2L1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 12/Cyclin-dependent kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559692] [GtoPdb: 1965] [UniProtKB: Q9NYV4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CDC2L5 kinase domain | B | 6 | pKd | 1000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 14/Cyclin-dependent kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921] | ||||||||
| ChEMBL | Binding affinity to PFTK1 | B | 6.14 | pKd | 720 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PFTK1 kinase domain | B | 6.14 | pKd | 720 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 15/Cyclin-dependent kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5856] [GtoPdb: 1968] [UniProtKB: Q96Q40] | ||||||||
| ChEMBL | Binding affinity to PFTAIRE2 | B | 5.89 | pKd | 1300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PFTAIRE2 kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 16/Cyclin-dependent kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PCTK1 | B | 7.57 | pKd | 27 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PCTK1 kinase domain | B | 7.57 | pKd | 27 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 17/Cyclin-dependent kinase 17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PCTK2 | B | 6.14 | pKd | 720 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PCTK2 kinase domain | B | 6.14 | pKd | 720 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 18/Cyclin-dependent kinase 18 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PCTK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PCTK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 19/Cyclin-dependent kinase 19 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1] | ||||||||
| ChEMBL | Binding affinity to CDK11 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK11 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.48 | pKd | 330 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CDK2 | B | 7.7 | pKd | 20 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK2 kinase domain | B | 7.7 | pKd | 20 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Cyclin-dependent kinase 2 homolog in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908388] [UniProtKB: P61075] | ||||||||
| ChEMBL | Binding constant for PFPK5(P.falciparum) kinase domain | B | 5.25 | pKd | 5600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526] | ||||||||
| ChEMBL | Binding affinity to CDK3 | B | 6.38 | pKd | 420 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK3 kinase domain | B | 6.38 | pKd | 420 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.43 | pKd | 37 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.06 | pKd | 866 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CDK4-cyclinD3 kinase domain | B | 7.46 | pKd | 35 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for CDK4-cyclinD1 kinase domain | B | 7.52 | pKd | 30 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.81 | pKd | 1564 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CDK5 | B | 6.39 | pKd | 410 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK5 kinase domain | B | 6.39 | pKd | 410 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.76 | pKd | 1757 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CDK7 | B | 7.06 | pKd | 87 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK7 kinase domain | B | 7.06 | pKd | 87 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 8/Cyclin-dependent kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336] | ||||||||
| ChEMBL | Binding affinity to CDK8 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK8 kinase domain | B | 5.1 | pKd | 8000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CDK9 | B | 6.28 | pKd | 530 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK9 kinase domain | B | 6.28 | pKd | 530 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532] | ||||||||
| ChEMBL | Binding constant for CDKL1 kinase domain | B | 6.31 | pKd | 490 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase like 2/Cyclin-dependent kinase-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5728] [GtoPdb: 1983] [UniProtKB: Q92772] | ||||||||
| ChEMBL | Binding affinity to CDKL2 | B | 7.37 | pKd | 43 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDKL2 kinase domain | B | 7.37 | pKd | 43 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin-dependent kinase like 3/Cyclin-dependent kinase-like 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163117] [GtoPdb: 1984] [UniProtKB: Q8IVW4] | ||||||||
| ChEMBL | Binding affinity to CDKL3 | B | 6.37 | pKd | 430 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDKL3 kinase domain | B | 6.37 | pKd | 430 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin-dependent kinase like 5/Cyclin-dependent kinase-like 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163112] [GtoPdb: 1986] [UniProtKB: O76039] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CDKL5 | B | 8 | pKd | 10 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDKL5 kinase domain | B | 8 | pKd | 10 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin G associated kinase/Cyclin-G-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.16 | pKd | 694 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to GAK | B | 8.14 | pKd | 7.3 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GAK kinase domain | B | 8.14 | pKd | 7.3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Cysteine--tRNA ligase, cytoplasmic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105937] [UniProtKB: P49589] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Cytochrome c1, heme protein, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105975] [UniProtKB: P08574] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| BMX non-receptor tyrosine kinase/Cytoplasmic tyrosine-protein kinase BMX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813] | ||||||||
| ChEMBL | Binding affinity to BMX | B | 6.7 | pKd | 200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BMX kinase domain | B | 6.7 | pKd | 200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| dCTP pyrophosphatase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769292] [UniProtKB: Q9H773] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| death associated protein kinase 1/Death-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355] | ||||||||
| ChEMBL | Binding affinity to DAPK1 | B | 7.1 | pKd | 80 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DAPK1 kinase domain | B | 7.1 | pKd | 80 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| death associated protein kinase 2/Death-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4] | ||||||||
| ChEMBL | Binding affinity to DAPK2 | B | 7.2 | pKd | 63 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DAPK2 kinase domain | B | 7.2 | pKd | 63 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293] | ||||||||
| ChEMBL | Binding affinity to DAPK3 | B | 7.09 | pKd | 82 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DAPK3 kinase domain | B | 7.09 | pKd | 82 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Delta(24)-sterol reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331059] [UniProtKB: Q15392] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Deoxycytidine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2447] [UniProtKB: P27707] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to DDR2 | B | 6.4 | pKd | 400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DDR2 kinase domain | B | 6.4 | pKd | 400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| DnaJ homolog subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189122] [UniProtKB: P31689] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| DNA replication licensing factor MCM4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105745] [UniProtKB: P33991] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| DNA topoisomerase II alpha/DNA topoisomerase 2-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1806] [GtoPdb: 2637] [UniProtKB: P11388] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| DNA topoisomerase 2-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3396] [UniProtKB: Q02880] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| dual serine/threonine and tyrosine protein kinase/Dual serine/threonine and tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908386] [GtoPdb: 2008] [UniProtKB: Q6XUX3] | ||||||||
| ChEMBL | Binding constant for RIPK5 kinase domain | B | 8.28 | pKd | 5.3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.93 | pKd | 1162 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MEK1 | B | 8.46 | pKd | 3.5 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK1 kinase domain | B | 8.46 | pKd | 3.5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.24 | pKd | 569 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MEK2 | B | 8.41 | pKd | 3.9 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK2 kinase domain | B | 8.41 | pKd | 3.9 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.92 | pKd | 120 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MEK3 | B | 8.3 | pKd | 5 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK3 kinase domain | B | 8.3 | pKd | 5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.1 | pKd | 790 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MEK4 | B | 8.42 | pKd | 3.8 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK4 kinase domain | B | 8.42 | pKd | 3.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.75 | pKd | 1794 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MEK5 kinase domain | B | 8.15 | pKd | 7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.06 | pKd | 87 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MEK6 | B | 7.36 | pKd | 44 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK6 kinase domain | B | 7.36 | pKd | 44 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733] | ||||||||
| ChEMBL | Binding constant for MKK7 kinase domain | B | 7.1 | pKd | 80 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC like kinase 1/Dual specificity protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.75 | pKd | 179 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CLK1 | B | 8.02 | pKd | 9.6 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CLK1 kinase domain | B | 8.02 | pKd | 9.6 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CLK2 | B | 7.36 | pKd | 44 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CLK2 kinase domain | B | 7.36 | pKd | 44 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CLK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CLK4 | B | 8.52 | pKd | 3 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CLK4 kinase domain | B | 8.52 | pKd | 3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] | ||||||||
| ChEMBL | Binding affinity to TTK | B | 8.19 | pKd | 6.5 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TTK kinase domain | B | 8.19 | pKd | 6.5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TESK1 | B | 6.54 | pKd | 290 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TESK1 kinase domain | B | 6.54 | pKd | 290 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.73 | pKd | 1858 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to DYRK1A | B | 7.7 | pKd | 20 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DYRK1A kinase domain | B | 7.7 | pKd | 20 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of NanoLuc-fused DYRK1A (unknown origin) transfected in HEK293 cells using tracer K10 incubated for 1 hr by NanoBRET assay | B | 7.92 | pIC50 | 12 | nM | IC50 | Eur J Med Chem (2022) 229: 114054-114054 [PMID:34959172] |
| dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] | ||||||||
| ChEMBL | Binding affinity to DYRK1B | B | 7.54 | pKd | 29 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DYRK1B kinase domain | B | 7.54 | pKd | 29 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| dual specificity tyrosine phosphorylation regulated kinase 2/Dual specificity tyrosine-phosphorylation-regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630] | ||||||||
| ChEMBL | Binding affinity to DYRK2 | B | 7.66 | pKd | 22 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DYRK2 kinase domain | B | 7.66 | pKd | 22 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Dynamin-like GTPase OPA1, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105705] [UniProtKB: O60313] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| eukaryotic translation initiation factor 2 alpha kinase 4/eIF-2-alpha kinase GCN2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8] | ||||||||
| ChEMBL | Binding affinity to GCN2 Kin.Dom.2, S808G mutant | B | 8.39 | pKd | 4.1 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain | B | 8.39 | pKd | 4.1 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TP53 regulating kinase/EKC/KEOPS complex subunit TP53RK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938223] [GtoPdb: 2248] [UniProtKB: Q96S44] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Electron transfer flavoprotein subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105744] [UniProtKB: P38117] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Elongation factor Tu, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105970] [UniProtKB: P49411] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHA1 | B | 6.42 | pKd | 380 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA1 kinase domain | B | 6.42 | pKd | 380 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHA2 | B | 6.1 | pKd | 790 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA2 kinase domain | B | 6.1 | pKd | 790 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320] | ||||||||
| ChEMBL | Binding affinity to EPHA3 | B | 6.8 | pKd | 160 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA3 kinase domain | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHA4 | B | 5.77 | pKd | 1700 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA4 kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHA5 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA5 kinase domain | B | 5.23 | pKd | 5900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A6/Ephrin type-A receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33] | ||||||||
| ChEMBL | Binding affinity to EPHA6 | B | 5.92 | pKd | 1200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA6 kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHA7 | B | 6.59 | pKd | 260 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA7 kinase domain | B | 6.59 | pKd | 260 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322] | ||||||||
| ChEMBL | Binding affinity to EPHA8 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762] | ||||||||
| ChEMBL | Binding affinity to EPHB1 | B | 5.28 | pKd | 5200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB1 kinase domain | B | 5.28 | pKd | 5200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHB2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB2 kinase domain | B | 5.16 | pKd | 6900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHB3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHB4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB4 kinase domain | B | 5.16 | pKd | 6900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B6/Ephrin type-B receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5836] [GtoPdb: 1834] [UniProtKB: O15197] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHB6 | B | 7.01 | pKd | 98 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB6 kinase domain | B | 7.01 | pKd | 98 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| epidermal growth factor receptor/Epidermal growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EGFR(L747-S752del, P753S) kinase domain | B | 5.85 | pKd | 1400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(S752-I759del) kinase domain | B | 5.85 | pKd | 1400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to EGFR G719C mutant | B | 5.92 | pKd | 1200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR(G719C) kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(G719S) kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to EGFR G719S mutant | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to EGFR | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to EGFR L858R mutant | B | 6.07 | pKd | 860 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR(L858R) kinase domain | B | 6.07 | pKd | 860 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(L861Q) kinase domain | B | 6.1 | pKd | 800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to EGFR L861Q mutant | B | 6.1 | pKd | 800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR(L747-T751del,Sins) kinase domain | B | 6.25 | pKd | 560 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(E746-A750del) kinase domain | B | 6.4 | pKd | 400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(L747-E749del, A750P) kinase domain | B | 6.49 | pKd | 320 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to EGFR L858R,T790M mutant | B | 7.52 | pKd | 30 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR(T790M) kinase domain | B | 7.8 | pKd | 16 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(L858R,T790M) kinase domain | B | 8.11 | pKd | 7.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to DDR1 | B | 6.29 | pKd | 510 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DDR1 kinase domain | B | 6.29 | pKd | 510 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| eukaryotic translation initiation factor 2 alpha kinase 1/Eukaryotic translation initiation factor 2-alpha kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6029] [GtoPdb: 2015] [UniProtKB: Q9BQI3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EIF2AK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Eukaryotic translation initiation factor 5B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105852] [UniProtKB: O60841] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Exosome RNA helicase MTR4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105889] [UniProtKB: P42285] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Ferrochelatase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879831] [UniProtKB: P22830] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to FGFR1 | B | 6.51 | pKd | 310 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR1 kinase domain | B | 6.51 | pKd | 310 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802] | ||||||||
| ChEMBL | Binding affinity to FGFR2 | B | 6.18 | pKd | 660 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR2 kinase domain | B | 6.18 | pKd | 660 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
| ChEMBL | Binding affinity to FGFR3 G697C mutant | B | 6.14 | pKd | 730 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR3(G697C) kinase domain | B | 6.14 | pKd | 730 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to FGFR3 | B | 6.24 | pKd | 580 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR3 kinase domain | B | 6.24 | pKd | 580 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455] | ||||||||
| ChEMBL | Binding affinity to FGFR4 | B | 5.74 | pKd | 1800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR4 kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to FAK | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FAK kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| General transcription and DNA repair factor IIH helicase subunit XPD in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105743] [UniProtKB: P18074] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Glycine--tRNA ligase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105815] [UniProtKB: P41250] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Glycogen phosphorylase, brain form in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3856] [UniProtKB: P11216] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Glycogen phosphorylase, liver form in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2568] [UniProtKB: P06737] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to GSK3A | B | 5.64 | pKd | 2300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GSK3A kinase domain | B | 5.64 | pKd | 2300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to GSK3B | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GSK3B kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| G protein-coupled receptor kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5861] [GtoPdb: 1468] [UniProtKB: P32298] | ||||||||
| ChEMBL | Binding affinity to GRK4 | B | 7.92 | pKd | 12 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GRK4 kinase domain | B | 7.92 | pKd | 12 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| G protein-coupled receptor kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6144] [GtoPdb: 1470] [UniProtKB: P43250] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| GTP-binding nuclear protein Ran in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741190] [UniProtKB: P62826] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| GTP-binding protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105780] [UniProtKB: Q9BZE4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Guanine nucleotide-binding protein G(i) subunit alpha-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105887] [UniProtKB: P04899] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Haem oxygenase 2/Heme oxygenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2546] [GtoPdb: 1442] [UniProtKB: P30519] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MET(M1250T) kinase domain | B | 6.32 | pKd | 480 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to MET M1250T mutant | B | 6.48 | pKd | 330 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MET kinase domain | B | 6.54 | pKd | 290 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to MET | B | 6.64 | pKd | 230 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MET(Y1235D) kinase domain | B | 7.39 | pKd | 41 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to MET Y1235D mutant | B | 7.52 | pKd | 30 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| neurotrophic receptor tyrosine kinase 1/High affinity nerve growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.25 | pKd | 561 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TRKA | B | 8.08 | pKd | 8.3 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TRKA kinase domain | B | 8.08 | pKd | 8.3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02] | ||||||||
| ChEMBL | Binding affinity to HIPK1 | B | 6.23 | pKd | 590 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HIPK1 kinase domain | B | 6.23 | pKd | 590 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6] | ||||||||
| ChEMBL | Binding affinity to HIPK2 | B | 6.43 | pKd | 370 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HIPK2 kinase domain | B | 6.43 | pKd | 370 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422] | ||||||||
| ChEMBL | Binding affinity to HIPK3 | B | 6.6 | pKd | 250 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HIPK3 kinase domain | B | 6.6 | pKd | 250 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| homeodomain interacting protein kinase 4/Homeodomain-interacting protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075167] [GtoPdb: 2036] [UniProtKB: Q8NE63] | ||||||||
| ChEMBL | Binding affinity to HIPK4 | B | 6.82 | pKd | 150 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HIPK4 kinase domain | B | 6.82 | pKd | 150 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| hormonally up-regulated Neu-associated kinase/Hormonally up-regulated neu tumor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795165] [GtoPdb: 2037] [UniProtKB: P57058] | ||||||||
| ChEMBL | Binding affinity to HUNK | B | 6.24 | pKd | 570 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HUNK kinase domain | B | 6.24 | pKd | 570 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa-B kinase subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] | ||||||||
| ChEMBL | Binding affinity to IKK-alpha | B | 8.05 | pKd | 9 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IKK-alpha kinase domain | B | 8.05 | pKd | 9 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa-B kinase subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
| ChEMBL | Binding affinity to IKK-beta | B | 7.92 | pKd | 12 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IKK-beta kinase domain | B | 7.92 | pKd | 12 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa-B kinase subunit epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.19 | pKd | 642 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to IKK-epsilon | B | 7.96 | pKd | 11 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IKK-epsilon kinase domain | B | 7.96 | pKd | 11 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to IGF1R | B | 5.38 | pKd | 4200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IGF1R kinase domain | B | 5.38 | pKd | 4200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to INSR | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for INSR kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Insulin receptor-related receptor/Insulin receptor-related protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616] | ||||||||
| ChEMBL | Binding affinity to INSRR | B | 5.74 | pKd | 1800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for INSRR kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| integrin linked kinase/Integrin-linked protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5247] [GtoPdb: 2041] [UniProtKB: Q13418] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] | ||||||||
| ChEMBL | Binding affinity to PRKR | B | 6.92 | pKd | 120 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKR kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to IRAK1 | B | 8.21 | pKd | 6.1 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IRAK1 kinase domain | B | 8.21 | pKd | 6.1 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.83 | pKd | 147 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to IRAK3 | B | 7.8 | pKd | 16 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IRAK3 kinase domain | B | 7.8 | pKd | 16 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.06 | pKd | 88 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for IRAK4 kinase domain | B | 8.77 | pKd | 1.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Isoleucine--tRNA ligase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105821] [UniProtKB: Q9NSE4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007] | ||||||||
| ChEMBL | Binding constant for LRRK2 kinase domain | B | 8.44 | pKd | 3.6 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for LRRK2(G2019S) kinase domain | B | 8.6 | pKd | 2.5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376] | ||||||||
| ChEMBL | Binding affinity to LTK | B | 6.31 | pKd | 490 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LTK kinase domain | B | 6.31 | pKd | 490 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to LIMK1 | B | 5.8 | pKd | 1600 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LIMK1 kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to LIMK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LIMK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Long-chain-fatty-acid--CoA ligase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105818] [UniProtKB: Q9ULC5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| colony stimulating factor 1 receptor/Macrophage colony-stimulating factor 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
| ChEMBL | Binding affinity to CSF1R | B | 6.96 | pKd | 110 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSF1R kinase domain | B | 6.96 | pKd | 110 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of human FMS expressed in growth factor dependent mouse FDC-P1 cells assessed as inhibition of FMS-mediated cell proliferation in presence human CSF1 after 48 hrs by resazurin dye reduction assay | B | 1.49 | pIC50 | 1.49 | - | logIC50 | Bioorg Med Chem (2010) 18: 1789-1797 [PMID:20156689] |
| ChEMBL | Inhibition of human FMS expressed in growth factor dependent mouse FDC-P1 cells assessed as inhibition of FMS-mediated cell proliferation in presence human CSF1 after 48 hrs by resazurin dye reduction assay | B | 7.51 | pIC50 | 31 | nM | IC50 | Bioorg Med Chem (2010) 18: 1789-1797 [PMID:20156689] |
| macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MST1R | B | 5.09 | pKd | 8200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MST1R kinase domain | B | 5.09 | pKd | 8200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAPKAPK2 | B | 6.64 | pKd | 230 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAPKAPK2 kinase domain | B | 6.64 | pKd | 230 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAPKAPK5 | B | 6.03 | pKd | 930 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAPKAPK5 kinase domain | B | 6.03 | pKd | 930 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
| ChEMBL | Binding affinity to MKNK1 | B | 7.25 | pKd | 56 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MKNK1 kinase domain | B | 7.25 | pKd | 56 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MAPK interacting serine/threonine kinase 2/MAP kinase-interacting serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9] | ||||||||
| ChEMBL | Binding affinity to MKNK2 | B | 8.85 | pKd | 1.4 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MKNK2 kinase domain | B | 8.85 | pKd | 1.4 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| microtubule affinity regulating kinase 3/MAP/microtubule affinity-regulating kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.99 | pKd | 103 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MARK3 | B | 7.31 | pKd | 49 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MARK3 kinase domain | B | 7.31 | pKd | 49 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34] | ||||||||
| ChEMBL | Binding affinity to MARK4 | B | 6.92 | pKd | 120 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MARK4 kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.14 | pKd | 73 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| KIT proto-oncogene, receptor tyrosine kinase/Mast/stem cell growth factor receptor Kit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Binding affinity to KIT V559D,V654A mutant | B | 6.42 | pKd | 380 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT(V559D,V654A) kinase domain | B | 6.42 | pKd | 380 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to KIT | B | 6.82 | pKd | 150 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT kinase domain | B | 6.82 | pKd | 150 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for KIT(V559D) kinase domain | B | 7.12 | pKd | 76 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to KIT V559D mutant | B | 7.12 | pKd | 76 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to KIT V559D,T670I mutant | B | 7.35 | pKd | 45 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT(V559D,T670I) kinase domain | B | 7.35 | pKd | 45 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for KIT(L576P) kinase domain | B | 7.4 | pKd | 40 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to KIT L576P mutant | B | 7.4 | pKd | 40 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT(A829P) kinase domain | B | 7.46 | pKd | 35 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for KIT(D816H) kinase domain | B | 7.96 | pKd | 11 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for KIT(D816V) kinase domain | B | 8.15 | pKd | 7.1 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to KIT D816V mutant | B | 8.15 | pKd | 7.1 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.73 | pKd | 185 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MELK | B | 7.59 | pKd | 26 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MELK kinase domain | B | 7.59 | pKd | 26 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| megakaryocyte-associated tyrosine kinase/Megakaryocyte-associated tyrosine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4175] [GtoPdb: 2101] [UniProtKB: P42679] | ||||||||
| ChEMBL | Binding affinity to CTK | B | 6.01 | pKd | 970 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CTK kinase domain | B | 6.01 | pKd | 970 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase, membrane associated tyrosine/threonine 1/Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PKMYT1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PKMYT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Microtubule associated serine/threonine kinase 1/Microtubule-associated serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163128] [GtoPdb: 1510] [UniProtKB: Q9Y2H9] | ||||||||
| ChEMBL | Binding affinity to MAST1 | B | 7.72 | pKd | 19 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAST1 kinase domain | B | 7.72 | pKd | 19 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Midasin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105779] [UniProtKB: Q9NU22] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.39 | pKd | 41 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MINK | B | 8.44 | pKd | 3.6 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MINK kinase domain | B | 8.44 | pKd | 3.6 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ERK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 10/Mitogen-activated protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.55 | pKd | 28 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to JNK3 | B | 7.92 | pKd | 12 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JNK3 kinase domain | B | 7.92 | pKd | 12 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 11/Mitogen-activated protein kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to p38-beta | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for p38-beta kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 12/Mitogen-activated protein kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778] | ||||||||
| ChEMBL | Binding affinity to p38-gamma | B | 6.43 | pKd | 370 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for p38-gamma kinase domain | B | 6.43 | pKd | 370 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 13/Mitogen-activated protein kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264] | ||||||||
| ChEMBL | Binding affinity to p38-delta | B | 5.46 | pKd | 3500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for p38-delta kinase domain | B | 5.46 | pKd | 3500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 14/Mitogen-activated protein kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to p38-alpha | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for p38-alpha kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ERK8 | B | 8.31 | pKd | 4.9 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK8 kinase domain | B | 8.31 | pKd | 4.9 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 3/Mitogen-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ERK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK1 kinase domain | B | 5.01 | pKd | 9800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152] | ||||||||
| ChEMBL | Binding affinity to ERK4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659] | ||||||||
| ChEMBL | Binding affinity to ERK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ERK5 | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK5 kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 8/Mitogen-activated protein kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.11 | pKd | 783 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to JNK1 | B | 7.96 | pKd | 11 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JNK1 kinase domain | B | 7.96 | pKd | 11 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 9/Mitogen-activated protein kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.76 | pKd | 1729 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to JNK2 | B | 6.49 | pKd | 320 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JNK2 kinase domain | B | 6.49 | pKd | 320 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP3K1 | B | 5.36 | pKd | 4400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K1 kinase domain | B | 5.36 | pKd | 4400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779] | ||||||||
| ChEMBL | Binding affinity to MLK2 | B | 7.82 | pKd | 15 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MLK2 kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.81 | pKd | 154 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MLK3 | B | 7.74 | pKd | 18 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MLK3 kinase domain | B | 7.74 | pKd | 18 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to human MLK3 | B | 7.74 | pKd | 18 | nM | Kd | J Med Chem (2013) 56: 8032-8048 [PMID:24044867] |
| mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852] | ||||||||
| ChEMBL | Binding constant for DLK kinase domain | B | 6.08 | pKd | 840 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 13/Mitogen-activated protein kinase kinase kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163124] [GtoPdb: 2073] [UniProtKB: O43283] | ||||||||
| ChEMBL | Binding affinity to LZK | B | 6.47 | pKd | 340 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LZK kinase domain | B | 6.47 | pKd | 340 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 15/Mitogen-activated protein kinase kinase kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163127] [GtoPdb: 2075] [UniProtKB: Q6ZN16] | ||||||||
| ChEMBL | Binding affinity to MAP3K15 | B | 8.47 | pKd | 3.4 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K15 kinase domain | B | 8.47 | pKd | 3.4 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 19/Mitogen-activated protein kinase kinase kinase 19 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6191] [GtoPdb: 2076] [UniProtKB: Q56UN5] | ||||||||
| ChEMBL | Binding affinity to YSK4 | B | 9.28 | pKd | 0.52 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YSK4 kinase domain | B | 9.28 | pKd | 0.52 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.65 | pKd | 2260 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP3K2 | B | 8.32 | pKd | 4.8 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K2 kinase domain | B | 8.32 | pKd | 4.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mitogen-activated protein kinase kinase kinase 20 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ZAK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ZAK kinase domain | B | 5.17 | pKd | 6700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.62 | pKd | 2386 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP3K3 | B | 8.22 | pKd | 6 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K3 kinase domain | B | 8.22 | pKd | 6 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP3K4 | B | 5.59 | pKd | 2600 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K4 kinase domain | B | 5.59 | pKd | 2600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.2 | pKd | 631 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ASK1 | B | 7.15 | pKd | 70 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ASK1 kinase domain | B | 7.15 | pKd | 70 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 6/Mitogen-activated protein kinase kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163123] [GtoPdb: 2081] [UniProtKB: O95382] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.42 | pKd | 378 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ASK2 | B | 6.77 | pKd | 170 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ASK2 kinase domain | B | 6.77 | pKd | 170 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318] | ||||||||
| ChEMBL | Binding affinity to TAK1 | B | 8.54 | pKd | 2.9 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TAK1 kinase domain | B | 8.54 | pKd | 2.9 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192] | ||||||||
| ChEMBL | Binding affinity to MLK1 | B | 8.46 | pKd | 3.5 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MLK1 kinase domain | B | 8.46 | pKd | 3.5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.6 | pKd | 252 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to HPK1 | B | 7.42 | pKd | 38 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HPK1 kinase domain | B | 7.42 | pKd | 38 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.2 | pKd | 63 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP4K2 | B | 8.33 | pKd | 4.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP4K2 kinase domain | B | 8.33 | pKd | 4.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.81 | pKd | 1565 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP4K3 | B | 6.96 | pKd | 110 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP4K3 kinase domain | B | 6.96 | pKd | 110 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.04 | pKd | 91 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP4K4 | B | 7.64 | pKd | 23 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP4K4 kinase domain | B | 7.64 | pKd | 23 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.76 | pKd | 173 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP4K5 | B | 7.37 | pKd | 43 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP4K5 kinase domain | B | 7.37 | pKd | 43 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| BUB1 mitotic checkpoint serine/threonine kinase/Mitotic checkpoint serine/threonine-protein kinase BUB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1772932] [GtoPdb: 1949] [UniProtKB: O43683] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146] | ||||||||
| ChEMBL | Binding affinity to MUSK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MUSK kinase domain | B | 5.39 | pKd | 4100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Myosin-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105746] [UniProtKB: P35580] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Myosin-14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105888] [UniProtKB: Q7Z406] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| myosin IIIA/Myosin-IIIa in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5546] [GtoPdb: 2112] [UniProtKB: Q8NEV4] | ||||||||
| ChEMBL | Binding affinity to MYO3A | B | 6.59 | pKd | 260 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYO3A kinase domain | B | 6.59 | pKd | 260 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| myosin IIIB/Myosin-IIIb in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5654] [GtoPdb: 2113] [UniProtKB: Q8WXR4] | ||||||||
| ChEMBL | Binding affinity to MYO3B | B | 6.11 | pKd | 770 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYO3B kinase domain | B | 6.11 | pKd | 770 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| myosin light chain kinase 3/Myosin light chain kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4627] [GtoPdb: 2110] [UniProtKB: Q32MK0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.02 | pKd | 95 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MLCK kinase domain | B | 7.92 | pKd | 12 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| myosin light chain kinase 2/Myosin light chain kinase 2, skeletal/cardiac muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2777] [GtoPdb: 1553] [UniProtKB: Q9H1R3] | ||||||||
| ChEMBL | Binding affinity to MYLK2 | B | 7.25 | pKd | 56 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYLK2 kinase domain | B | 7.25 | pKd | 56 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6] | ||||||||
| ChEMBL | Binding affinity to SgK085 | B | 7.54 | pKd | 29 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYLK4 kinase domain | B | 7.54 | pKd | 29 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MYLK | B | 7.89 | pKd | 13 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYLK kinase domain | B | 7.89 | pKd | 13 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to MLCK | B | 7.92 | pKd | 12 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| DM1 protein kinase/Myotonin-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013] | ||||||||
| ChEMBL | Binding affinity to DMPK | B | 6.62 | pKd | 240 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DMPK kinase domain | B | 6.62 | pKd | 240 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105781] [UniProtKB: Q9P0J0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.97 | pKd | 108 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TNK1 | B | 8.03 | pKd | 9.3 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TNK1 kinase domain | B | 8.03 | pKd | 9.3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tyrosine kinase 2/Non-receptor tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TYK2(JH2domain-pseudokinase) | B | 6.04 | pKd | 910 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TYK2(JH2domain-pseudokinase) kinase domain | B | 6.04 | pKd | 910 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to TYK2(JH1domain-catalytic) | B | 7.82 | pKd | 15 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TYK2(JH1domain-catalytic) kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to recombinant human TYK2 kinase domain by fluorescence polarization assay | B | 8.14 | pKd | 7.3 | nM | Kd | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| ChEMBL | Inhibition of recombinant human TYK2 assessed as inhibition of substrate phosphorylation measured every 5 mins for 30 mins by LANCE Ultra kinase assay | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288] | ||||||||
| ChEMBL | Binding affinity to TRKC | B | 7.85 | pKd | 14 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TRKC kinase domain | B | 7.85 | pKd | 14 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285] | ||||||||
| ChEMBL | Binding affinity to ARK5 | B | 8.43 | pKd | 3.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ARK5 kinase domain | B | 8.43 | pKd | 3.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.14 | pKd | 72 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to SNARK | B | 9 | pKd | 1 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SNARK kinase domain | B | 9 | pKd | 1 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Obg-like ATPase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105704] [UniProtKB: Q9NTK5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| calcium/calmodulin dependent serine protein kinase/Peripheral plasma membrane protein CASK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908381] [GtoPdb: 1959] [UniProtKB: O14936] | ||||||||
| ChEMBL | Binding constant for CASK kinase domain | B | 6.48 | pKd | 330 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Peroxisomal acyl-coenzyme A oxidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105748] [UniProtKB: Q15067] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Peroxisomal acyl-coenzyme A oxidase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105817] [UniProtKB: O15254] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Phenylalanine--tRNA ligase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105969] [UniProtKB: Q9NSD9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Phosphatidylethanolamine-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105856] [UniProtKB: P30086] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma/Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163120] [GtoPdb: 2288] [UniProtKB: O75747] | ||||||||
| ChEMBL | Binding affinity to PIK3C2G | B | 6.64 | pKd | 230 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3C2G kinase domain | B | 6.64 | pKd | 230 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
| ChEMBL | Binding constant for PIK3CA(I800L) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PIK3CA | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA E542K mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA E545A mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA E545K mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CA(E545K) kinase domain | B | 5.13 | pKd | 7400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(E542K) kinase domain | B | 5.23 | pKd | 5900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(E545A) kinase domain | B | 5.25 | pKd | 5600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(Q546K) kinase domain | B | 5.27 | pKd | 5400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PIK3CA Q546K mutant | B | 5.27 | pKd | 5400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CA kinase domain | B | 5.31 | pKd | 4900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PIK3CA C420R mutant | B | 5.31 | pKd | 4900 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CA(C420R) kinase domain | B | 5.31 | pKd | 4900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PIK3CA M1043I mutant | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CA(M1043I) kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(H1047Y) kinase domain | B | 6.19 | pKd | 650 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PIK3CA H1047Y mutant | B | 6.19 | pKd | 650 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CA(H1047L) kinase domain | B | 7.31 | pKd | 49 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PIK3CA H1047L mutant | B | 7.31 | pKd | 49 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
| ChEMBL | Binding affinity to PIK3CB | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CB kinase domain | B | 5.17 | pKd | 6700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
| ChEMBL | Binding affinity to PIK3CD | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CD kinase domain | B | 5.4 | pKd | 4000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
| ChEMBL | Binding affinity to PIK3CG | B | 6.46 | pKd | 350 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CG kinase domain | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol 4-kinase beta/Phosphatidylinositol 4-kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8] | ||||||||
| ChEMBL | Binding affinity to PIK4CB | B | 6.54 | pKd | 290 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK4CB kinase domain | B | 6.54 | pKd | 290 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750] | ||||||||
| ChEMBL | Binding affinity to PIK3C2B | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3C2B kinase domain | B | 5.28 | pKd | 5200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755] | ||||||||
| ChEMBL | Binding affinity to PIP5K1A | B | 7.44 | pKd | 36 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIP5K1A kinase domain | B | 7.44 | pKd | 36 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4-phosphate 5-kinase type 1 gamma/Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908383] [GtoPdb: 2165] [UniProtKB: O60331] | ||||||||
| ChEMBL | Binding constant for PIP5K1C kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-5-phosphate 4-kinase type 2 alpha/Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795194] [GtoPdb: 2858] [UniProtKB: P48426] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol 5-phosphate 4-kinase type-2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356] | ||||||||
| ChEMBL | Binding affinity to PIP5K2B | B | 7.74 | pKd | 18 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIP5K2B kinase domain | B | 7.74 | pKd | 18 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PIP5K2C kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphorylase kinase catalytic subunit gamma 2/Phosphorylase b kinase gamma catalytic chain, liver/testis isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.91 | pKd | 122 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PHKG2 | B | 8.77 | pKd | 1.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PHKG2 kinase domain | B | 8.77 | pKd | 1.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphorylase kinase catalytic subunit gamma 1/Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816] | ||||||||
| ChEMBL | Binding affinity to PHKG1 | B | 9.41 | pKd | 0.39 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PHKG1 kinase domain | B | 9.41 | pKd | 0.39 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
| ChEMBL | Binding affinity to PDGFRA | B | 6.42 | pKd | 380 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PDGFRA kinase domain | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.76 | pKd | 1735 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PDGFRB kinase domain | B | 7.54 | pKd | 29 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PDGFRB | B | 7.55 | pKd | 28 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| tankyrase 2/Poly [ADP-ribose] polymerase tankyrase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6154] [GtoPdb: 3109] [UniProtKB: Q9H2K2] | ||||||||
| ChEMBL | Binding affinity to TNK2 | B | 8.18 | pKd | 6.6 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| Probable ATP-dependent RNA helicase DDX6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105783] [UniProtKB: P26196] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Protein delta homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5671] [UniProtKB: P80370] | ||||||||
| ChEMBL | Binding affinity to DLK | B | 6.08 | pKd | 840 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to DLK (unknown origin) assessed as dissociation constant | B | 6.08 | pKd | 840 | nM | Kd | Eur J Med Chem (2023) 255: 115404-115404 [PMID:37098296] |
| protein kinase C alpha/Protein kinase C alpha type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.74 | pKd | 1799 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PKAC-alpha | B | 6.66 | pKd | 220 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| protein kinase C beta/Protein kinase C beta type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase C delta/Protein kinase C delta type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PRKCD | B | 6.62 | pKd | 240 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKCD kinase domain | B | 6.62 | pKd | 240 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase C epsilon/Protein kinase C epsilon type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
| ChEMBL | Binding affinity to PRKCE | B | 6.8 | pKd | 160 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKCE kinase domain | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase C eta/Protein kinase C eta type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723] | ||||||||
| ChEMBL | Binding affinity to PRKCH | B | 6.85 | pKd | 140 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKCH kinase domain | B | 6.85 | pKd | 140 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase C iota/Protein kinase C iota type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKCI kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase C theta/Protein kinase C theta type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PRKCQ | B | 7 | pKd | 100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKCQ kinase domain | B | 7 | pKd | 100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase C zeta/Protein kinase C zeta type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein tyrosine kinase 2 beta/Protein-tyrosine kinase 2-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.96 | pKd | 1088 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PYK2 | B | 7.39 | pKd | 41 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PYK2 kinase domain | B | 7.39 | pKd | 41 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein tyrosine kinase 6/Protein-tyrosine kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.84 | pKd | 14295 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to BRK | B | 5.77 | pKd | 1700 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BRK kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ret proto-oncogene/Proto-oncogene tyrosine-protein kinase receptor Ret in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.69 | pKd | 205 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RET kinase domain | B | 7.7 | pKd | 20 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RET | B | 7.7 | pKd | 20 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to RET M918T mutant | B | 7.85 | pKd | 14 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RET(M918T) kinase domain | B | 7.85 | pKd | 14 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for RET(V804L) kinase domain | B | 8.17 | pKd | 6.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RET(V804L) | B | 8.17 | pKd | 6.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to RET V804M mutant | B | 8.33 | pKd | 4.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RET(V804M) kinase domain | B | 8.33 | pKd | 4.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
| ChEMBL | Binding affinity to ROS1 | B | 7.59 | pKd | 26 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ROS1 kinase domain | B | 7.59 | pKd | 26 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase Src in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to SRC | B | 6.19 | pKd | 640 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRC kinase domain | B | 6.19 | pKd | 640 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Pyridoxal kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075181] [UniProtKB: O00764] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| AKT serine/threonine kinase 1/RAC-alpha serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to AKT1 | B | 5.36 | pKd | 4400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AKT1 kinase domain | B | 5.36 | pKd | 4400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| AKT serine/threonine kinase 2/RAC-beta serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to AKT2 | B | 5.68 | pKd | 2100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AKT2 kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| AKT serine/threonine kinase 3/RAC-gamma serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to AKT3 | B | 5.21 | pKd | 6200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AKT3 kinase domain | B | 5.21 | pKd | 6200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Raf-1 proto-oncogene, serine/threonine kinase/RAF proto-oncogene serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| ChEMBL | Binding affinity to RAF1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RAF1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Ras-related protein Rab-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105971] [UniProtKB: P61026] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| RAB27A, member RAS oncogene family/Ras-related protein Rab-27A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105702] [GtoPdb: 2916] [UniProtKB: P51159] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Ras-related protein Rab-6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105703] [UniProtKB: P20340] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546] | ||||||||
| ChEMBL | Binding affinity to RIPK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| receptor interacting serine/threonine kinase 2/Receptor-interacting serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to RIPK2 | B | 6.19 | pKd | 640 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIPK2 kinase domain | B | 6.19 | pKd | 640 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| receptor interacting serine/threonine kinase 3/Receptor-interacting serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795199] [GtoPdb: 2191] [UniProtKB: Q9Y572] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| receptor interacting serine/threonine kinase 4/Receptor-interacting serine/threonine-protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6083] [GtoPdb: 2192] [UniProtKB: P57078] | ||||||||
| ChEMBL | Binding affinity to RIPK4 | B | 7.89 | pKd | 13 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIPK4 kinase domain | B | 7.89 | pKd | 13 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.91 | pKd | 122 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| GtoPdb | - | - | 8.07 | pKd | 8.5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-51 [PMID:22037378] |
| ChEMBL | Binding affinity to FLT3 | B | 8.07 | pKd | 8.5 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to FLT3 catalytic domain by KinomeScan kinase binding assay | B | 8.07 | pKd | 8.5 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT3 kinase domain | B | 8.07 | pKd | 8.5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to human FLT3 | B | 8.07 | pKd | 8.5 | nM | Kd | J Med Chem (2013) 56: 8032-8048 [PMID:24044867] |
| ChEMBL | Binding constant for FLT3(R834Q) kinase domain | B | 8.15 | pKd | 7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for FLT3(K663Q) kinase domain | B | 8.27 | pKd | 5.4 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to FLT3 K663Q mutant | B | 8.27 | pKd | 5.4 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT3(ITD) kinase domain | B | 8.82 | pKd | 1.5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for FLT3(N841I) kinase domain | B | 8.85 | pKd | 1.4 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to FLT3 N841I mutant | B | 8.85 | pKd | 1.4 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT3(D835H) kinase domain | B | 9.18 | pKd | 0.66 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to FLT3 D835H mutant | B | 9.18 | pKd | 0.66 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT3(D835Y) kinase domain | B | 9.24 | pKd | 0.57 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to FLT3 D835Y mutant | B | 9.24 | pKd | 0.57 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Inhibition of FLT3 D835H mutant (unknown origin) | B | 7.92 | pIC50 | 11.9 | nM | IC50 | J Med Chem (2020) 63: 12403-12428 [PMID:32659083] |
| ChEMBL | Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay | B | 8.09 | pIC50 | 8.2 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1768-1770 [PMID:23411073] |
| ChEMBL | Inhibition of FLT3 by HTRF assay | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2033-2037 [PMID:20153646] |
| ChEMBL | In Vitro Kinase Assay: The inhibition of the FLT3 kinase activity was measured with homogeneous, time-resolved fluorescence (HTRF) assays. Recombinant proteins containing the FLT3 kinase domain were purchased from Invitrogen (Carlsbad, Calif., USA). Optimal enzyme, ATP, and substrate concentrations were established with the HTRF KinEASE kit (Cisbio, France) according to the manufacturer's instructions. The FLT3 enzymes were mixed with serially diluted compounds and peptide substrates in a kinase reaction buffer (50 mM HEPES (pH 7.0), 500 μM ATP, 0.1 mM sodium orthovanadate, 5 mM MgCl2, 1 mM DTT, 0.01% bovine serum albumin (BSA), and 0.02% NaN3). Ten microliters of the total volume of the kinase reaction were added to the wells of a 96-well assay plate. The kinase reactions were incubated for 30 min at 25° C. For the detection of the phospho-substrate, the Eu3b-Cryptate-conjugated mouse monoclonal antibody (PT66) and the streptavidin-XL665 (SA-XL) were added, and the reactions were then incubated for 1 hour at 25° C. The signal was measured on an Victor X5 multi-label reader (PerkinElmer, Waltham, Mass., USA). The curve was fitted by nonlinear regression, and the IC50 was calculated using GraphPad Prism 5.01 (GraphPad, La Jolla, Calif., USA). | B | 8.52 | pIC50 | 3 | nM | IC50 | US-11370779-B2. Pharmaceutical composition for preventing or treating acute myeloid leukemia or metastatic breast cancer (2022) |
| ChEMBL | Inhibition of FLT3-WT (unknown origin) | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem (2022) 56: 116596-116596 [PMID:35033885] |
| ChEMBL | Inhibition of FLT3 (unknown origin) | B | 8.52 | pIC50 | 3 | nM | IC50 | RSC Med Chem (2022) 13: 798-816 [PMID:35923716] |
| ChEMBL | Inhibition of human FLT3 | B | 8.52 | pIC50 | 3 | nM | IC50 | RSC Med Chem (2022) 13: 798-816 [PMID:35923716] |
| ChEMBL | Inhibition of FLT3 (unknown origin) | B | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986] |
| ChEMBL | Inhibition of recombinant His-tagged human FLT3 expressed in baculovirus expression system using peptide substrate incubated for 30 mins in presence of ATP by HTRF assay | B | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2020) 195: 112205-112205 [PMID:32272419] |
| ChEMBL | Inhibition of FLT3 autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay | B | 8.59 | pIC50 | 2.6 | nM | IC50 | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Inhibition of FLT3-mediated STAT5 phosphorylation in human MV411 cells after 1 hr by immunoblotting analysis | B | 8.6 | pIC50 | 2.5 | nM | IC50 | Medchemcomm (2012) 3: 22-27 |
| ChEMBL | Inhibition of FLT3 (unknown origin) autophosphorylation | B | 8.7 | pIC50 | 2 | nM | IC50 | Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986] |
| ChEMBL | Inhibition of FLT3 ITD mutant autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay | B | 8.82 | pIC50 | 1.5 | nM | IC50 | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034796] [GtoPdb: 1807] [UniProtKB: Q00342] | ||||||||
| ChEMBL | Inhibition of FLT3 autophosphorylation in mouse BaF3/ITD cells after 1 hr by immunoblotting analysis | B | 8.82 | pIC50 | 1.5 | nM | IC50 | Medchemcomm (2012) 3: 22-27 |
| erb-b2 receptor tyrosine kinase 2/Receptor tyrosine-protein kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
| ChEMBL | Binding affinity to ERBB2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERBB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| erb-b2 receptor tyrosine kinase 3/Receptor tyrosine-protein kinase erbB-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5838] [GtoPdb: 1798] [UniProtKB: P21860] | ||||||||
| ChEMBL | Binding affinity to ERBB3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERBB3 kinase domain | B | 5.26 | pKd | 5500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| erb-b2 receptor tyrosine kinase 4/Receptor tyrosine-protein kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303] | ||||||||
| ChEMBL | Binding affinity to ERBB4 | B | 5.85 | pKd | 1400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERBB4 kinase domain | B | 5.85 | pKd | 1400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ROCK1 | B | 7.25 | pKd | 56 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ROCK1 kinase domain | B | 7.25 | pKd | 56 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ROCK2 | B | 7.15 | pKd | 71 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ROCK2 kinase domain | B | 7.15 | pKd | 71 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| G protein-coupled receptor kinase 1/Rhodopsin kinase GRK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5607] [GtoPdb: 1465] [UniProtKB: Q15835] | ||||||||
| ChEMBL | Binding affinity to GRK1 | B | 7.62 | pKd | 24 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GRK1 kinase domain | B | 7.62 | pKd | 24 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| G protein-coupled receptor kinase 7/Rhodopsin kinase GRK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075133] [GtoPdb: 1471] [UniProtKB: Q8WTQ7] | ||||||||
| ChEMBL | Binding affinity to GRK7 | B | 8.14 | pKd | 7.2 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GRK7 kinase domain | B | 8.14 | pKd | 7.2 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.61 | pKd | 2477 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domain | B | 5.62 | pKd | 2400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA3(Kin.Dom.1-N-terminal) | B | 6.54 | pKd | 290 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to RPS6KA4(Kin.Dom.1-N-terminal) | B | 7.21 | pKd | 62 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domain | B | 7.55 | pKd | 28 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349] | ||||||||
| ChEMBL | Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA5(Kin.Dom.2-C-terminal) | B | 6.02 | pKd | 960 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain | B | 7.06 | pKd | 88 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA5(Kin.Dom.1-N-terminal) | B | 7.38 | pKd | 42 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.69 | pKd | 2022 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal) | B | 5.89 | pKd | 1300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domain | B | 6.54 | pKd | 290 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676] | ||||||||
| ChEMBL | Binding affinity to RPS6KA1(Kin.Dom.2-C-terminal) | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.49 | pKd | 324 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA4(Kin.Dom.1-N-terminal) kinase domain | B | 7.21 | pKd | 62 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA1(Kin.Dom.1-N-terminal) | B | 7.55 | pKd | 28 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha-5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to RPS6KA2(Kin.Dom.2-C-terminal) | B | 5.92 | pKd | 1200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domain | B | 6.02 | pKd | 960 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA2(Kin.Dom.1-N-terminal) | B | 7.06 | pKd | 88 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RPS6KA5(Kin.Dom.1-N-terminal) kinase domain | B | 7.38 | pKd | 42 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32] | ||||||||
| ChEMBL | Binding affinity to RPS6KA6(Kin.Dom.2-C-terminal) | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain | B | 5.04 | pKd | 9100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.01 | pKd | 981 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to RPS6KA6(Kin.Dom.1-N-terminal) | B | 6.96 | pKd | 110 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domain | B | 6.96 | pKd | 110 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to SBK1 | B | 6.7 | pKd | 200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for S6K1 kinase domain | B | 7.16 | pKd | 69 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Ribosyldihydronicotinamide dehydrogenase [quinone] in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3959] [UniProtKB: P16083] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.49 | pKd | 3257 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| RNA cytidine acetyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105935] [UniProtKB: Q9H0A0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| S-adenosylmethionine synthase isoform type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313835] [UniProtKB: P31153] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Septin-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105891] [UniProtKB: Q9UHD8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.01 | pKd | 98 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to LOK | B | 8.24 | pKd | 5.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LOK kinase domain | B | 8.24 | pKd | 5.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to STK16 | B | 7.72 | pKd | 19 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK16 kinase domain | B | 7.72 | pKd | 19 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5] | ||||||||
| ChEMBL | Binding affinity to DRAK1 | B | 8.47 | pKd | 3.4 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DRAK1 kinase domain | B | 8.47 | pKd | 3.4 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768] | ||||||||
| ChEMBL | Binding affinity to DRAK2 | B | 8.3 | pKd | 5 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DRAK2 kinase domain | B | 8.3 | pKd | 5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0] | ||||||||
| ChEMBL | Binding affinity to MST3 | B | 6.12 | pKd | 760 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MST3 kinase domain | B | 6.12 | pKd | 760 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506] | ||||||||
| ChEMBL | Binding affinity to YSK1 | B | 7.01 | pKd | 97 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YSK1 kinase domain | B | 7.01 | pKd | 97 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine-protein kinase MST4/Serine/threonine-protein kinase 26 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MST4 | B | 6.64 | pKd | 230 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MST4 kinase domain | B | 6.64 | pKd | 230 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 3/Serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.52 | pKd | 30 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MST2 | B | 8.62 | pKd | 2.4 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MST2 kinase domain | B | 8.62 | pKd | 2.4 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 32A/Serine/threonine-protein kinase 32A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6150] [GtoPdb: 1537] [UniProtKB: Q8WU08] | ||||||||
| ChEMBL | Binding constant for YANK1 kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57] | ||||||||
| ChEMBL | Binding affinity to YANK2 | B | 5.23 | pKd | 5900 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YANK2 kinase domain | B | 5.23 | pKd | 5900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6] | ||||||||
| ChEMBL | Binding affinity to YANK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YANK3 kinase domain | B | 5.1 | pKd | 8000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3] | ||||||||
| ChEMBL | Binding affinity to STK33 | B | 7.59 | pKd | 26 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK33 kinase domain | B | 7.59 | pKd | 26 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 35/Serine/threonine-protein kinase 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5651] [GtoPdb: 2222] [UniProtKB: Q8TDR2] | ||||||||
| ChEMBL | Binding affinity to STK35 | B | 6.09 | pKd | 810 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK35 kinase domain | B | 6.09 | pKd | 810 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7] | ||||||||
| ChEMBL | Binding affinity to STK36 | B | 5.42 | pKd | 3800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK36 kinase domain | B | 5.42 | pKd | 3800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Serine/threonine kinase 38/Serine/threonine-protein kinase 38 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075155] [GtoPdb: 1517] [UniProtKB: Q15208] | ||||||||
| ChEMBL | Binding affinity to NDR1 | B | 6.66 | pKd | 220 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NDR1 kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1] | ||||||||
| ChEMBL | Binding affinity to NDR2 | B | 6.43 | pKd | 370 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NDR2 kinase domain | B | 6.43 | pKd | 370 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 4/Serine/threonine-protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.35 | pKd | 45 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MST1 | B | 8.52 | pKd | 3 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MST1 kinase domain | B | 8.52 | pKd | 3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| A-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase A-Raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169596] [GtoPdb: 1933] [UniProtKB: P10398] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ATR checkpoint kinase/Serine/threonine-protein kinase ATR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5024] [GtoPdb: 1935] [UniProtKB: Q13535] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to BRAF | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to BRAF V600E mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BRAF kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for BRAF(V600E) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| BR serine/threonine kinase 1/Serine/threonine-protein kinase BRSK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3] | ||||||||
| ChEMBL | Binding affinity to BRSK1 | B | 7.6 | pKd | 25 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BRSK1 kinase domain | B | 7.6 | pKd | 25 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| BR serine/threonine kinase 2/Serine/threonine-protein kinase BRSK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3] | ||||||||
| ChEMBL | Binding affinity to BRSK2 | B | 7.8 | pKd | 16 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BRSK2 kinase domain | B | 7.8 | pKd | 16 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.14 | pKd | 72 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CHEK1 | B | 8.55 | pKd | 2.8 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CHEK1 kinase domain | B | 8.55 | pKd | 2.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
| ChEMBL | Binding affinity to CHEK2 | B | 6.68 | pKd | 210 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CHEK2 kinase domain | B | 6.68 | pKd | 210 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase D1/Serine/threonine-protein kinase D1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
| ChEMBL | Binding affinity to PRKD1 | B | 7.85 | pKd | 14 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKD1 kinase domain | B | 7.85 | pKd | 14 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.34 | pKd | 46 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PRKD2 | B | 8.09 | pKd | 8.1 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKD2 kinase domain | B | 8.09 | pKd | 8.1 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase D3/Serine/threonine-protein kinase D3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.28 | pKd | 53 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PRKD3 | B | 8.05 | pKd | 8.9 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKD3 kinase domain | B | 8.05 | pKd | 8.9 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075] | ||||||||
| ChEMBL | Binding affinity to DCAMKL1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DCAMKL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568] | ||||||||
| ChEMBL | Binding affinity to DCAMKL2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DCAMKL2 kinase domain | B | 5.35 | pKd | 4500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098] | ||||||||
| ChEMBL | Binding affinity to DCAMKL3 | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DCAMKL3 kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.38 | pKd | 42 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ERN1 | B | 8.24 | pKd | 5.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERN1 kinase domain | B | 8.24 | pKd | 5.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| endoplasmic reticulum to nucleus signaling 2/Serine/threonine-protein kinase/endoribonuclease IRE2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105932] [GtoPdb: 2021] [UniProtKB: Q76MJ5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.53 | pKd | 292 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ciliogenesis associated kinase 1/Serine/threonine-protein kinase ICK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163126] [GtoPdb: 2038] [UniProtKB: Q9UPZ9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ICK | B | 7.41 | pKd | 39 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ICK kinase domain | B | 7.41 | pKd | 39 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835] | ||||||||
| GtoPdb | - | - | 7.52 | pKd | 30 | nM | Kd | Blood (2009) 114: 2984-92 [PMID:19654408] |
| ChEMBL | Binding affinity to LATS1 | B | 7.52 | pKd | 30 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LATS1 kinase domain | B | 7.52 | pKd | 30 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.6 | pKd | 25 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7] | ||||||||
| GtoPdb | - | - | 9 | pKd | 1 | nM | Kd | Blood (2009) 114: 2984-92 [PMID:19654408] |
| ChEMBL | Binding affinity to LATS2 | B | 9 | pKd | 1 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LATS2 kinase domain | B | 9 | pKd | 1 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| male germ cell associated kinase/Serine/threonine-protein kinase MAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163106] [GtoPdb: 2061] [UniProtKB: P20794] | ||||||||
| ChEMBL | Binding affinity to MAK | B | 5.77 | pKd | 1700 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAK kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2] | ||||||||
| ChEMBL | Binding affinity to MARK1 | B | 7.08 | pKd | 83 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MARK1 kinase domain | B | 7.08 | pKd | 83 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| microtubule affinity regulating kinase 2/Serine/threonine-protein kinase MARK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.8 | pKd | 157 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MARK2 | B | 7.85 | pKd | 14 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MARK2 kinase domain | B | 7.85 | pKd | 14 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MRCKA | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MRCKA kinase domain | B | 5.04 | pKd | 9200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MRCKB | B | 6 | pKd | 1000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MRCKB kinase domain | B | 6 | pKd | 1000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to DMPK2 | B | 5.6 | pKd | 2500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DMPK2 kinase domain | B | 5.6 | pKd | 2500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
| ChEMBL | Binding constant for MTOR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase N1/Serine/threonine-protein kinase N1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.7 | pKd | 198 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PKN1 | B | 8.28 | pKd | 5.3 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PKN1 kinase domain | B | 8.28 | pKd | 5.3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase N2/Serine/threonine-protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.79 | pKd | 164 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PKN2 | B | 8.74 | pKd | 1.8 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PKN2 kinase domain | B | 8.74 | pKd | 1.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase N3/Serine/threonine-protein kinase N3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3627581] [GtoPdb: 1522] [UniProtKB: Q6P5Z2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.86 | pKd | 1374 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to NEK1 | B | 5.6 | pKd | 2500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK1 kinase domain | B | 5.6 | pKd | 2500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 11/Serine/threonine-protein kinase Nek11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5638] [GtoPdb: 2116] [UniProtKB: Q8NG66] | ||||||||
| ChEMBL | Binding constant for NEK11 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 2/Serine/threonine-protein kinase Nek2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to NEK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK2 kinase domain | B | 5.31 | pKd | 4900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for NEK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957] | ||||||||
| ChEMBL | Binding constant for NEK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8] | ||||||||
| ChEMBL | Binding affinity to NEK5 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK5 kinase domain | B | 5.25 | pKd | 5600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 6/Serine/threonine-protein kinase Nek6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98] | ||||||||
| ChEMBL | Binding affinity to NEK6 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK6 kinase domain | B | 5.36 | pKd | 4400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 7/Serine/threonine-protein kinase Nek7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7] | ||||||||
| ChEMBL | Binding affinity to NEK7 | B | 5.4 | pKd | 4000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK7 kinase domain | B | 5.4 | pKd | 4000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 9/Serine/threonine-protein kinase Nek9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to NEK9 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK9 kinase domain | B | 5.27 | pKd | 5400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84] | ||||||||
| ChEMBL | Binding affinity to NIM1 | B | 5.74 | pKd | 1800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NIM1 kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| nemo like kinase/Serine/threonine-protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to NLK | B | 6.11 | pKd | 770 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NLK kinase domain | B | 6.11 | pKd | 770 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| oxidative stress responsive kinase 1/Serine/threonine-protein kinase OSR1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163104] [GtoPdb: 2132] [UniProtKB: O95747] | ||||||||
| ChEMBL | Binding affinity to OSR1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for OSR1 kinase domain | B | 5.1 | pKd | 8000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153] | ||||||||
| ChEMBL | Binding affinity to PAK1 | B | 7.52 | pKd | 30 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PAK1 kinase domain | B | 7.52 | pKd | 30 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PAK2 | B | 7.37 | pKd | 43 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PAK2 kinase domain | B | 7.37 | pKd | 43 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914] | ||||||||
| ChEMBL | Binding affinity to PAK3 | B | 7.46 | pKd | 35 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PAK3 kinase domain | B | 7.46 | pKd | 35 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.54 | pKd | 29 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PAK4 | B | 7.62 | pKd | 24 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PAK4 kinase domain | B | 7.62 | pKd | 24 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286] | ||||||||
| ChEMBL | Binding affinity to PAK7 | B | 7.62 | pKd | 24 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PAK7 kinase domain | B | 7.62 | pKd | 24 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PAK6 | B | 8 | pKd | 9.9 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PAK6 kinase domain | B | 8 | pKd | 9.9 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase pim-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PIM1 | B | 6.7 | pKd | 200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIM1 kinase domain | B | 6.7 | pKd | 200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase pim-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PIM2 | B | 6.6 | pKd | 250 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIM2 kinase domain | B | 6.6 | pKd | 250 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase pim-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] | ||||||||
| ChEMBL | Binding affinity to PIM3 | B | 7.74 | pKd | 18 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIM3 kinase domain | B | 7.74 | pKd | 18 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Serine/threonine-protein kinase PknB in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908385] [UniProtKB: P9WI81] | ||||||||
| ChEMBL | Binding constant for PKNB(M.tuberculosis) kinase domain | B | 7.26 | pKd | 55 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PLK1 | B | 6.66 | pKd | 220 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PLK1 kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| polo like kinase 2/Serine/threonine-protein kinase PLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5938] [GtoPdb: 2169] [UniProtKB: Q9NYY3] | ||||||||
| ChEMBL | Binding affinity to PLK2 | B | 6.48 | pKd | 330 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PLK2 kinase domain | B | 6.48 | pKd | 330 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
| ChEMBL | Binding affinity to PLK3 | B | 5.64 | pKd | 2300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PLK3 kinase domain | B | 5.64 | pKd | 2300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.05 | pKd | 90 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PLK4 | B | 8.82 | pKd | 1.5 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PLK4 kinase domain | B | 8.82 | pKd | 1.5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| pre-mRNA processing factor kinase PRP4K/Serine/threonine-protein kinase PRP4 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908382] [GtoPdb: 2177] [UniProtKB: Q13523] | ||||||||
| ChEMBL | Binding affinity to PRP4 | B | 6.26 | pKd | 550 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRP4 kinase domain | B | 6.26 | pKd | 550 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2] | ||||||||
| ChEMBL | Binding affinity to RIOK1 | B | 8.05 | pKd | 9 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIOK1 kinase domain | B | 8.05 | pKd | 9 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| RIO kinase 2/Serine/threonine-protein kinase RIO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6000] [GtoPdb: 2187] [UniProtKB: Q9BVS4] | ||||||||
| ChEMBL | Binding affinity to RIOK2 | B | 5.17 | pKd | 6700 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIOK2 kinase domain | B | 5.17 | pKd | 6700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730] | ||||||||
| ChEMBL | Binding affinity to RIOK3 (unknown origin) | B | 8.1 | pKd | 7.94 | nM | Kd | US-20200216545-A1. Compositions and methods for treating beta-globinopathies (2020) |
| ChEMBL | Binding affinity to RIOK3 | B | 8.11 | pKd | 7.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIOK3 kinase domain | B | 8.11 | pKd | 7.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RIOK3 (unknown origin) | B | 8.11 | pKd | 7.7 | nM | Kd | US-20200216545-A1. Compositions and methods for treating beta-globinopathies (2020) |
| SH3 domain binding kinase 1/Serine/threonine-protein kinase SBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163129] [GtoPdb: 2193] [UniProtKB: Q52WX2] | ||||||||
| ChEMBL | Binding constant for SBK1 kinase domain | B | 6.7 | pKd | 200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1] | ||||||||
| ChEMBL | Binding constant for SGK3 kinase domain | B | 8.24 | pKd | 5.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059] | ||||||||
| ChEMBL | Binding affinity to SIK | B | 7.09 | pKd | 82 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SIK kinase domain | B | 7.09 | pKd | 82 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.26 | pKd | 55 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to SIK2 | B | 7.82 | pKd | 15 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SIK2 kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SIK family kinase 3/Serine/threonine-protein kinase SIK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6149] [GtoPdb: 2199] [UniProtKB: Q9Y2K2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.07 | pKd | 848 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to QSK | B | 6.92 | pKd | 120 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for QSK kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 11/Serine/threonine-protein kinase STK11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to LKB1 | B | 7.24 | pKd | 57 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LKB1 kinase domain | B | 7.24 | pKd | 57 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TAO1 | B | 6.3 | pKd | 500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to TAOK1 | B | 7.15 | pKd | 70 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TAOK1 kinase domain | B | 7.15 | pKd | 70 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TAOK2 kinase domain | B | 6.3 | pKd | 500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TAOK3 | B | 7.07 | pKd | 86 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TAOK3 kinase domain | B | 7.07 | pKd | 86 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.01 | pKd | 977 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TBK1 | B | 7.74 | pKd | 18 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TBK1 kinase domain | B | 7.74 | pKd | 18 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18] | ||||||||
| ChEMBL | Binding affinity to TNNI3K | B | 5.68 | pKd | 2100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TNNI3K kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8] | ||||||||
| ChEMBL | Binding affinity to TLK1 | B | 6.96 | pKd | 110 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TLK1 kinase domain | B | 6.96 | pKd | 110 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8] | ||||||||
| ChEMBL | Binding affinity to TLK2 | B | 7.19 | pKd | 64 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TLK2 kinase domain | B | 7.19 | pKd | 64 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ULK1 | B | 6 | pKd | 1000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ULK1 kinase domain | B | 6 | pKd | 1000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8] | ||||||||
| ChEMBL | Binding affinity to ULK2 | B | 7.22 | pKd | 60 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ULK2 kinase domain | B | 7.22 | pKd | 60 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.67 | pKd | 212 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ULK3 | B | 8.31 | pKd | 4.9 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ULK3 kinase domain | B | 8.31 | pKd | 4.9 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07] | ||||||||
| ChEMBL | Binding constant for VRK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Signal recognition particle receptor subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105934] [UniProtKB: P08240] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| signal transducer and activator of transcription 3/Signal transducer and activator of transcription 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4026] [GtoPdb: 2994] [UniProtKB: P40763] | ||||||||
| ChEMBL | Inhibition of STAT3 phosphorylation in HEL 92.1.7 cells incubated for 24 hrs by Western blot analysis | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986] |
| signal transducer and activator of transcription 5A/Signal transducer and activator of transcription 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5403] [GtoPdb: 3221] [UniProtKB: P42229] | ||||||||
| ChEMBL | Inhibition of STAT5 phosphorylation in HEL 92.1.7 cells incubated for 24 hrs by Western blot analysis | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986] |
| SNF related kinase/SNF-related serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908384] [GtoPdb: 2202] [UniProtKB: Q9NRH2] | ||||||||
| ChEMBL | Binding constant for SNRK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SRSF protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4] | ||||||||
| ChEMBL | Binding affinity to SRPK1 | B | 8 | pKd | 10 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRPK1 kinase domain | B | 8 | pKd | 10 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SRSF protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362] | ||||||||
| ChEMBL | Binding affinity to SRPK2 | B | 7.29 | pKd | 51 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRPK2 kinase domain | B | 7.29 | pKd | 51 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SRSF protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1] | ||||||||
| ChEMBL | Binding affinity to SRPK3 | B | 7.89 | pKd | 13 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRPK3 kinase domain | B | 7.89 | pKd | 13 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| STE20 like kinase/STE20-like serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.12 | pKd | 750 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to SLK | B | 7.46 | pKd | 35 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SLK kinase domain | B | 7.46 | pKd | 35 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| STE20 related adaptor alpha/STE20-related kinase adapter protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795198] [GtoPdb: 2227] [UniProtKB: Q7RTN6] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| serine/threonine kinase 39/STE20/SPS1-related proline-alanine-rich protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163108] [GtoPdb: 2224] [UniProtKB: Q9UEW8] | ||||||||
| ChEMBL | Binding affinity to STK39 | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK39 kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Structural maintenance of chromosomes protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105747] [UniProtKB: Q14683] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Structural maintenance of chromosomes protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105890] [UniProtKB: O95347] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105973] [UniProtKB: Q9P2R7] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7] | ||||||||
| ChEMBL | Binding affinity to TSSK1B | B | 7.01 | pKd | 98 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TSSK1B kinase domain | B | 7.01 | pKd | 98 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| transforming growth factor beta receptor 1/TGF-beta receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.02 | pKd | 966 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TGFBR1 | B | 6.92 | pKd | 120 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TGFBR1 kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| transforming growth factor beta receptor 2/TGF-beta receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.89 | pKd | 1280 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TGFBR2 | B | 6.27 | pKd | 540 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TGFBR2 kinase domain | B | 6.27 | pKd | 540 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Thyroid hormone receptor-associated protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105820] [UniProtKB: Q9Y2W1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| TRAF2 and NCK interacting kinase/TRAF2 and NCK-interacting protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TNIK | B | 8.27 | pKd | 5.4 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TNIK kinase domain | B | 8.27 | pKd | 5.4 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TRPM6/Transient receptor potential cation channel subfamily M member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628470] [GtoPdb: 498] [UniProtKB: Q9BX84] | ||||||||
| ChEMBL | Binding constant for TRPM6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ABL1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 E255K mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 F317I mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 F317L mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 H396P mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 Q252H mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ABL1(F317I)-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to ABL1 Y253F mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ABL1(F317L)-non phosphorylated kinase domain | B | 5.12 | pKd | 7600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(F317I)-phosphorylated kinase domain | B | 5.31 | pKd | 4900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to ABL1 M351T mutant | B | 5.48 | pKd | 3300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ABL1-non phosphorylated kinase domain | B | 5.49 | pKd | 3200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(Q252H)-non phosphorylated kinase domain | B | 5.6 | pKd | 2500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(F317L)-phosphorylated kinase domain | B | 5.66 | pKd | 2200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(H396P)-non phosphorylated kinase domain | B | 6 | pKd | 1000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1-phosphorylated kinase domain | B | 6 | pKd | 1000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(T315I)-non phosphorylated kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(Y253F)-phosphorylated kinase domain | B | 6.04 | pKd | 910 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(H396P)-phosphorylated kinase domain | B | 6.06 | pKd | 870 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(E255K)-phosphorylated kinase domain | B | 6.08 | pKd | 840 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(Q252H)-phosphorylated kinase domain | B | 6.08 | pKd | 830 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(M351T)-phosphorylated kinase domain | B | 6.11 | pKd | 780 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to ABL1 T315I mutant | B | 6.46 | pKd | 350 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ABL1(T315I)-phosphorylated kinase domain | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ABL2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ABL2 kinase domain | B | 5.19 | pKd | 6500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Blk in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451] | ||||||||
| ChEMBL | Binding affinity to BLK | B | 6.8 | pKd | 160 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BLK kinase domain | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.93 | pKd | 1179 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to BTK | B | 7.18 | pKd | 66 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BTK kinase domain | B | 7.18 | pKd | 66 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CSK | B | 6.59 | pKd | 260 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSK kinase domain | B | 6.59 | pKd | 260 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| FER tyrosine kinase/Tyrosine-protein kinase Fer in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.63 | pKd | 235 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to FER | B | 7.55 | pKd | 28 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FER kinase domain | B | 7.55 | pKd | 28 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase Fes/Fps in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.93 | pKd | 1186 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to FES | B | 6.43 | pKd | 370 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FES kinase domain | B | 6.43 | pKd | 370 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fgr in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to FGR | B | 7.28 | pKd | 52 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGR kinase domain | B | 7.28 | pKd | 52 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to FRK | B | 6.13 | pKd | 740 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FRK kinase domain | B | 6.13 | pKd | 740 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to FYN | B | 7.08 | pKd | 84 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FYN kinase domain | B | 7.08 | pKd | 84 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to HCK | B | 6.57 | pKd | 270 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HCK kinase domain | B | 6.57 | pKd | 270 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
| ChEMBL | Binding affinity to ITK | B | 6.54 | pKd | 290 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ITK kinase domain | B | 6.54 | pKd | 290 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to JAK1 JH2 domain | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JAK1(JH2domain-pseudokinase) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to JH1 catalytic domain JAK1 | B | 8.06 | pKd | 8.8 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JAK1(JH1domain-catalytic) kinase domain | B | 8.06 | pKd | 8.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to recombinant human JAK1 kinase domain by fluorescence polarization assay | B | 8.55 | pKd | 2.8 | nM | Kd | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| ChEMBL | Inhibition of recombinant human JAK1 assessed as inhibition of substrate phosphorylation measured every 5 mins for 30 mins by LANCE Ultra kinase assay | B | 8.46 | pIC50 | 3.5 | nM | IC50 | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| ChEMBL | Binding affinity to recombinant human JAK2 kinase domain (840 to 1132 residues) assessed as dissociation constant by ITC analysis | B | 8.31 | pKd | 4.9 | nM | Kd | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| ChEMBL | Binding affinity to JH1 catalytic domain JAK2 | B | 8.43 | pKd | 3.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JAK2(JH1domain-catalytic) kinase domain | B | 8.43 | pKd | 3.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to recombinant human JAK2 kinase domain by fluorescence polarization assay | B | 8.54 | pKd | 2.9 | nM | Kd | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| ChEMBL | Inhibition of JAK2-mediated erythropoietin-induced STAT5 phosphorylation in human TF-1 cells pretreated for 60 mins followed by erythropoietin addition and measured after 15 mins by pacific orange/pacific blue NHS esters based Beckmann coulter flow cytometer | B | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| ChEMBL | Inhibition of JAK2 V617F mutant phosphorylation in HEL 92.1.7 cells incubated for 24 hrs by Western blot analysis | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986] |
| ChEMBL | Inhibition of recombinant human JAK2 assessed as inhibition of substrate phosphorylation measured every 5 mins for 30 mins by LANCE Ultra kinase assay | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| ChEMBL | Inhibition of JAK2 (unknown origin) in presence of ATP | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2020) 63: 12403-12428 [PMID:32659083] |
| ChEMBL | Inhibition of GST tagged JAK2 (unknown origin) expressed in insect cells | B | 9 | pIC50 | 1 | nM | IC50 | Leukemia (2009) 23: 1441-1445 [PMID:19295546] |
| ChEMBL | Inhibition of JAK2 (unknown origin) | B | 9 | pIC50 | 1 | nM | IC50 | RSC Med Chem (2022) 13: 798-816 [PMID:35923716] |
| ChEMBL | Inhibition of wild-type JAK2 (unknown origin) expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated with substrate for 60 mins followed by compound addition and measured after 20 mins by time-resolve fluorescence assay | B | 9.05 | pIC50 | 0.9 | nM | IC50 | Eur J Med Chem (2022) 239: 114551-114551 [PMID:35749986] |
| ChEMBL | Inhibition of JAK 2 (unknown origin) | B | 9.05 | pIC50 | 0.9 | nM | IC50 | J Med Chem (2022) 65: 893-921 [PMID:33539089] |
| Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| ChEMBL | Binding affinity to JH1 catalytic domain of JAK3 | B | 8.64 | pKd | 2.3 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JAK3(JH1domain-catalytic) kinase domain | B | 8.64 | pKd | 2.3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to recombinant human JAK3 kinase domain by fluorescence polarization assay | B | 8.96 | pKd | 1.1 | nM | Kd | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| ChEMBL | Inhibition of recombinant human JAK3 assessed as inhibition of substrate phosphorylation measured every 5 mins for 30 mins by LANCE Ultra kinase assay | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2024) 67: 10012-10024 [PMID:38843875] |
| LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lck in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to LCK | B | 6.37 | pKd | 430 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LCK kinase domain | B | 6.37 | pKd | 430 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to LYN | B | 6.72 | pKd | 190 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LYN kinase domain | B | 6.72 | pKd | 190 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MER proto-oncogene, tyrosine kinase/Tyrosine-protein kinase Mer in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866] | ||||||||
| ChEMBL | Binding affinity to MERTK | B | 7.49 | pKd | 32 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MERTK kinase domain | B | 7.49 | pKd | 32 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590] | ||||||||
| ChEMBL | Binding affinity to TIE1 | B | 6.17 | pKd | 680 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TIE1 kinase domain | B | 6.17 | pKd | 680 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418] | ||||||||
| ChEMBL | Binding affinity to TYRO3 | B | 6.19 | pKd | 650 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TYRO3 kinase domain | B | 6.19 | pKd | 650 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
| ChEMBL | Binding affinity to AXL | B | 7.46 | pKd | 35 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AXL kinase domain | B | 7.46 | pKd | 35 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6] | ||||||||
| ChEMBL | Binding affinity to SRMS | B | 6.09 | pKd | 820 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRMS kinase domain | B | 6.09 | pKd | 820 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.58 | pKd | 265 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to SYK | B | 8.02 | pKd | 9.5 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SYK kinase domain | B | 8.02 | pKd | 9.5 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tec protein tyrosine kinase/Tyrosine-protein kinase Tec in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TEC | B | 5.92 | pKd | 1200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TEC kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681] | ||||||||
| ChEMBL | Binding affinity to TXK | B | 6.18 | pKd | 660 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TXK kinase domain | B | 6.18 | pKd | 660 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase Yes in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to YES | B | 6.8 | pKd | 160 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YES kinase domain | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
| ChEMBL | Binding affinity to ZAP70 | B | 7.8 | pKd | 16 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ZAP70 kinase domain | B | 7.8 | pKd | 16 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Tyrosine--tRNA ligase, cytoplasmic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3179] [UniProtKB: P54577] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| U5 small nuclear ribonucleoprotein 200 kDa helicase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105972] [UniProtKB: O75643] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| UMP-CMP kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5681] [UniProtKB: P30085] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| aarF domain containing kinase 5/Uncharacterized aarF domain-containing protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105886] [GtoPdb: 1929] [UniProtKB: Q3MIX3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Uncharacterized protein FLJ45252 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105933] [UniProtKB: Q6ZSR9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 7.1 | pKd | 80 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| sugen kinase 110/Uncharacterized serine/threonine-protein kinase SBK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5116] [GtoPdb: 2290] [UniProtKB: P0C264] | ||||||||
| ChEMBL | Binding affinity to SgK110 | B | 6.92 | pKd | 120 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SgK110 kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| ChEMBL | Binding affinity to FLT1 | B | 6.92 | pKd | 120 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT1 kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Binding affinity to VEGFR2 | B | 6.66 | pKd | 220 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for VEGFR2 kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
| ChEMBL | Binding affinity to FLT4 | B | 7.77 | pKd | 17 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT4 kinase domain | B | 7.77 | pKd | 17 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Very long-chain specific acyl-CoA dehydrogenase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105892] [UniProtKB: P49748] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| WEE1 G2 checkpoint kinase/Wee1-like protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to WEE1 | B | 5.92 | pKd | 1200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for WEE1 kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| WEE2 oocyte meiosis inhibiting kinase/Wee1-like protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5095] [GtoPdb: 2279] [UniProtKB: P0C1S8] | ||||||||
| ChEMBL | Binding affinity to WEE2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for WEE2 kinase domain | B | 5.1 | pKd | 7900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
