cyclin dependent kinase 11A | PITSLRE subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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cyclin dependent kinase 11A

Target not currently curated in GtoImmuPdb

Target id: 1963

Nomenclature: cyclin dependent kinase 11A

Abbreviated Name: CDK11A

Family: PITSLRE subfamily

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 780 1p36.33 CDK11A cyclin dependent kinase 11A
Previous and Unofficial Names
CDC2L2 | CDC2L3 | CDK11-p110 | CDK11-p46 | CDK11-p58 | cell division cycle 2-like 2 (PITSLRE proteins) | Cell division cycle 2-like protein kinase 2 | Cell division protein kinase 11A | PITSLRE serine/threonine-protein kinase CDC2L2 | cyclin-dependent kinase 11A
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: CDC2L2
Ligand Sp. Type Action Value Parameter
AT-7519 Hs Inhibitor Inhibition 8.3 pKd
BMS-387032 Hs Inhibitor Inhibition 7.3 pKd
tozasertib Hs Inhibitor Inhibition 6.6 pKd
BMS-345541 Hs Inhibitor Inhibition 6.4 pKd
crizotinib Hs Inhibitor Inhibition 6.4 pKd
foretinib Hs Inhibitor Inhibition 6.3 pKd
barasertib-hQPA Hs Inhibitor Inhibition 6.0 pKd
AST-487 Hs Inhibitor Inhibition 6.0 pKd
linifanib Hs Inhibitor Inhibition 5.9 pKd
pazopanib Hs Inhibitor Inhibition 5.9 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

PITSLRE subfamily: cyclin dependent kinase 11A. Last modified on 20/03/2013. Accessed on 20/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1963.