cyclin dependent kinase 11A | PITSLRE subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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cyclin dependent kinase 11A

Target not currently curated in GtoImmuPdb

Target id: 1963

Nomenclature: cyclin dependent kinase 11A

Abbreviated Name: CDK11A

Family: PITSLRE subfamily

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 780 1p36.33 CDK11A cyclin dependent kinase 11A
Previous and Unofficial Names
CDC2L2 | CDC2L3 | CDK11-p110 | CDK11-p46 | CDK11-p58 | cell division cycle 2-like 2 (PITSLRE proteins) | Cell division cycle 2-like protein kinase 2 | Cell division protein kinase 11A | PITSLRE serine/threonine-protein kinase CDC2L2 | cyclin-dependent kinase 11A
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: CDC2L2
Ligand Sp. Type Action Value Parameter
AT-7519 Hs Inhibitor Inhibition 8.3 pKd
BMS-387032 Hs Inhibitor Inhibition 7.3 pKd
tozasertib Hs Inhibitor Inhibition 6.6 pKd
BMS-345541 Hs Inhibitor Inhibition 6.4 pKd
crizotinib Hs Inhibitor Inhibition 6.4 pKd
foretinib Hs Inhibitor Inhibition 6.3 pKd
barasertib-hQPA Hs Inhibitor Inhibition 6.0 pKd
AST-487 Hs Inhibitor Inhibition 6.0 pKd
linifanib Hs Inhibitor Inhibition 5.9 pKd
pazopanib Hs Inhibitor Inhibition 5.9 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »


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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

PITSLRE subfamily: cyclin dependent kinase 11A. Last modified on 20/03/2013. Accessed on 20/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,