serine/threonine kinase 25 | YSK subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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serine/threonine kinase 25

Target not currently curated in GtoImmuPdb

Target id: 2218

Nomenclature: serine/threonine kinase 25

Abbreviated Name: YSK1

Family: YSK subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 426 2q37.3 STK25 serine/threonine kinase 25
Mouse - 426 1 D Stk25 serine/threonine kinase 25 (yeast)
Rat - 426 9 q36 Stk25 serine/threonine kinase 25
Previous and Unofficial Names
SOK1
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Structure of human YSK1 (Yeast Sps1-Ste20-Related Kinase 1)
PDB Id:  2XIK
Resolution:  1.97Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 2-3

Key to terms and symbols Click column headers to sort
Target used in screen: YSK1
Ligand Sp. Type Action Value Parameter
neratinib Hs Inhibitor Inhibition 7.9 pKd
lestaurtinib Hs Inhibitor Inhibition 7.0 pKd
staurosporine Hs Inhibitor Inhibition 7.0 pKd
sunitinib Hs Inhibitor Inhibition 6.5 pKd
SU-14813 Hs Inhibitor Inhibition 6.4 pKd
bosutinib Hs Inhibitor Inhibition 6.1 pKd
dovitinib Hs Inhibitor Inhibition 5.9 pKd
AST-487 Hs Inhibitor Inhibition 5.9 pKd
midostaurin Hs Inhibitor Inhibition 5.7 pKd
PD-173955 Hs Inhibitor Inhibition 5.6 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/STK25(YSK1)
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Hs Inhibitor Inhibition 3.2
Cdk1/2 inhibitor III Hs Inhibitor Inhibition 8.2
bosutinib Hs Inhibitor Inhibition 10.1
PKR inhibitor Hs Inhibitor Inhibition 30.7
SB 218078 Hs Inhibitor Inhibition 34.4
JAK3 inhibitor VI Hs Inhibitor Inhibition 47.2
midostaurin Hs Inhibitor Inhibition 55.0
Gö 6983 Hs Inhibitor Inhibition 55.7
SU11652 Hs Inhibitor Inhibition 56.1
PKCbeta inhibitor Hs Inhibitor Inhibition 63.1
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]

2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

YSK subfamily: serine/threonine kinase 25. Last modified on 26/03/2013. Accessed on 21/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2218.