coenzyme Q8A | ABC1-B subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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coenzyme Q8A

Target not currently curated in GtoImmuPdb

Target id: 1927

Nomenclature: coenzyme Q8A

Abbreviated Name: ADCK3

Family: ABC1-B subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 647 1q42.11 COQ8A coenzyme Q8A
Mouse - 645 1 H4 Coq8a coenzyme Q8A
Rat - 649 13q26 Coq8a coenzyme Q8A
Previous and Unofficial Names
CABC1 | chaperone activity of bc1 complex-like, mitochondrial | chaperone, ABC1 activity of bc1 complex homolog | SCAR9 | ADCK3
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.-
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: ADCK3
Ligand Sp. Type Action Value Parameter
TG-100-115 Hs Inhibitor Inhibition 7.0 pKd
dasatinib Hs Inhibitor Inhibition 6.7 pKd
PD-173955 Hs Inhibitor Inhibition 6.0 pKd
tamatinib Hs Inhibitor Inhibition 6.0 pKd
canertinib Hs Inhibitor Inhibition 5.8 pKd
NVP-TAE684 Hs Inhibitor Inhibition 5.8 pKd
erlotinib Hs Inhibitor Inhibition 5.7 pKd
SB203580 Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd
GSK690693 Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Clinically-Relevant Mutations and Pathophysiology
Disease:  Coenzyme Q10 deficiency, primary, 4
Synonyms: Autosomal recessive ataxia due to ubiquinone deficiency [Orphanet: ORPHA139485]
Coenzyme Q10 deficiency disease [Disease Ontology: DOID:0050730]
Disease Ontology: DOID:0050730
OMIM: 612016
Orphanet: ORPHA139485

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

ABC1-B subfamily: coenzyme Q8A. Last modified on 18/08/2014. Accessed on 26/05/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1927.