Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	979	14q24.3	NEK9	NIMA related kinase 9
Mouse	-	984	12 D1	Nek9	NIMA (never in mitosis gene a)-related expressed kinase 9
Rat	-	958	6 q31	Nek9	NIMA-related kinase 9

Previous and Unofficial Names

NERCC | NIMA-related kinase 9

Database Links
Alphafold	Q8TD19 (Hs), Q8K1R7 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL5257 (Hs)
Ensembl Gene	ENSG00000119638 (Hs), ENSMUSG00000034290 (Mm), ENSRNOG00000058572 (Rn)
Entrez Gene	91754 (Hs), 217718 (Mm), 299204 (Rn)
Human Protein Atlas	ENSG00000119638 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:91754 (Hs), mmu:217718 (Mm), rno:299204 (Rn)
OMIM	609798 (Hs)
Pharos	Q8TD19 (Hs)
RefSeq Nucleotide	NM_033116 (Hs), NM_145138 (Mm), NM_001106747 (Rn)
RefSeq Protein	NP_149107 (Hs), NP_660120 (Mm), NP_001100217 (Rn)
UniProtKB	Q8TD19 (Hs), Q8K1R7 (Mm)
Wikipedia	NEK9 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/NEK9
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM K-252a Hs Inhibitor Inhibition 14.7 SB 218078 Hs Inhibitor Inhibition 23.4 staurosporine Hs Inhibitor Inhibition 27.2 PKR inhibitor Hs Inhibitor Inhibition 32.0 Cdk1/2 inhibitor III Hs Inhibitor Inhibition 39.1 dovitinib Hs Inhibitor Inhibition 58.9 midostaurin Hs Inhibitor Inhibition 64.4 JAK3 inhibitor VI Hs Inhibitor Inhibition 66.3 Syk inhibitor Hs Inhibitor Inhibition 67.3 aminopurvalanol A Hs Inhibitor Inhibition 69.4
Displaying the top 10 most potent ligands  View all ligands in screen »