Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	688	7q22.3	SRPK2	SRSF protein kinase 2
Mouse	-	681	5 10.36 cM	Srpk2	serine/arginine-rich protein specific kinase 2
Rat	-	681	4 q11	Srpk2	SRSF protein kinase 2

Previous and Unofficial Names

SFRS protein kinase 2 | SFRSK2 | SR protein kinase 2

Database Links
Alphafold	P78362 (Hs), O54781 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL5668 (Hs)
Ensembl Gene	ENSG00000135250 (Hs), ENSMUSG00000062604 (Mm), ENSRNOG00000010601 (Rn)
Entrez Gene	6733 (Hs), 20817 (Mm), 296753 (Rn)
Human Protein Atlas	ENSG00000135250 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:6733 (Hs), mmu:20817 (Mm), rno:296753 (Rn)
OMIM	602980 (Hs)
Pharos	P78362 (Hs)
RefSeq Nucleotide	NM_182691 (Hs), NM_009274 (Mm), NM_001106575 (Rn)
RefSeq Protein	NP_872633 (Hs), NP_033300 (Mm), NP_001100045 (Rn)
UniProtKB	P78362 (Hs), O54781 (Mm)
Wikipedia	SRPK2 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference URMC-099 Hs Inhibition - - 4 ⤷ [4] Description: Measured as % inhibition using 1μM compound.
Inhibitor Comments
SRPK2 activity is inhibited by >90% in the presence of 1μM URMC-099 [4].

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,5
Key to terms and symbols		Click column headers to sort
Target used in screen: SRPK2
Ligand Sp. Type Action Value Parameter KW-2449 Hs Inhibitor Inhibition 7.8 pKd lestaurtinib Hs Inhibitor Inhibition 7.3 pKd staurosporine Hs Inhibitor Inhibition 7.2 pKd fedratinib Hs Inhibitor Inhibition 7.0 pKd sunitinib Hs Inhibitor Inhibition 6.7 pKd SU-14813 Hs Inhibitor Inhibition 6.7 pKd dovitinib Hs Inhibitor Inhibition 6.5 pKd midostaurin Hs Inhibitor Inhibition 6.5 pKd PHA-665752 Hs Inhibitor Inhibition 6.3 pKd tozasertib Hs Inhibitor Inhibition 6.2 pKd
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EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,3
Key to terms and symbols		Click column headers to sort
Target used in screen: SRPK2/SRPK2
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM Cdk1/2 inhibitor III Hs Inhibitor Inhibition 17.1 3.0 -3.0 aminopurvalanol A Hs Inhibitor Inhibition 31.0 26.0 1.0 compound 52 [PMID: 9677190] Hs Inhibitor Inhibition 37.1 27.0 2.0 staurosporine Hs Inhibitor Inhibition 40.9 54.0 12.0 SU6656 Hs Inhibitor Inhibition 50.3 34.0 14.0 Syk inhibitor Hs Inhibitor Inhibition 51.4 36.0 13.0 purvalanol A Hs Inhibitor Inhibition 53.6 32.0 2.0 JNJ-7706621 Hs Inhibitor Inhibition 54.9 53.0 4.0 SU11274 Hs Inhibitor Inhibition 60.6 65.0 27.0 casein kinase II inhibitor III Hs Inhibitor Inhibition 62.0 103.0 89.0
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