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Target not currently curated in GtoImmuPdb
Target id: 2068
Nomenclature: mitogen-activated protein kinase kinase 7
Abbreviated Name: MKK7
Family: STE7 family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 419 | 19p13.2 | MAP2K7 | mitogen-activated protein kinase kinase 7 | |
Mouse | - | 535 | 8 A1.1 | Map2k7 | mitogen-activated protein kinase kinase 7 | |
Rat | - | 419 | 12p12 | Map2k7 | mitogen activated protein kinase kinase 7 | |
Gene and Protein Information Comments | ||||||
Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only the transcript variant generating the 419 amino acid protein has been supported and defined. Isoform B is postulated to contain a 43 amino acid insertion, translating to a 462 amino acid protein. |
Database Links ![]() |
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BRENDA | 2.7.12.2 |
ChEMBL Target | CHEMBL3530 (Hs), CHEMBL4523385 (Mm) |
Ensembl Gene | ENSG00000076984 (Hs), ENSMUSG00000002948 (Mm), ENSRNOG00000001047 (Rn) |
Entrez Gene | 5609 (Hs), 26400 (Mm), 363855 (Rn) |
Human Protein Atlas | ENSG00000076984 (Hs) |
KEGG Enzyme | 2.7.12.2 |
KEGG Gene | hsa:5609 (Hs), mmu:26400 (Mm), rno:363855 (Rn) |
OMIM | 603014 (Hs) |
Pharos | O14733 (Hs) |
RefSeq Nucleotide | NM_145185 (Hs), NM_011944 (Mm), NM_001025425 (Rn) |
RefSeq Protein | NP_660186 (Hs), NP_036074 (Mm), NP_001020596 (Rn) |
UniProtKB | O14733 (Hs), Q8CE90 (Mm), Q4KSH7 (Rn) |
Wikipedia | MAP2K7 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||
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Allosteric Modulators | |||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||
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DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,5 |
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Target used in screen: MKK7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen ![]() |
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A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 2... |
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Target used in screen: MKK7β/nd | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
Immuno Process Associations | ||||||||||||
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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]
3. Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y et al.. (2015) Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). J Med Chem, 58 (20): 8182-99. [PMID:26431428]
4. Rice KD, Aay N, Anand NK, Blazey CM, Bowles OJ, Bussenius J, Costanzo S, Curtis JK, Defina SC, Dubenko L et al.. (2012) Novel Carboxamide-Based Allosteric MEK Inhibitors: Discovery and Optimization Efforts toward XL518 (GDC-0973). ACS Med Chem Lett, 3 (5): 416-21. [PMID:24900486]
5. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
STE7 family: mitogen-activated protein kinase kinase 7. Last modified on 19/06/2018. Accessed on 15/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2068.