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STE7 family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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STE7 (also known as MAPKK, MAP2K or MEK) kinases are part of the MAPK signalling cascades. They are activated by phosphorylation by upstream STE11 (MAP3K, MAPKKK) kinases and phosphorylate downstream MAPK kinases. Small molecule pharmacological inhibitors, including negative allosteric modulators, of MEKs are used to disrupt signalling via the RAS-RAF-MEK-ERK pathway that drives proliferation in certain cancers.

Enzymes

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MEK1 (mitogen-activated protein kinase kinase 1) C Show summary » More detailed page go icon to follow link

MEK2 (mitogen-activated protein kinase kinase 2) C Show summary » More detailed page go icon to follow link

MKK3 (mitogen-activated protein kinase kinase 3) Show summary » More detailed page go icon to follow link

MKK4 (mitogen-activated protein kinase kinase 4) Show summary » More detailed page go icon to follow link

MEK5 (mitogen-activated protein kinase kinase 5) Show summary » More detailed page go icon to follow link

MKK6 (mitogen-activated protein kinase kinase 6) Show summary » More detailed page go icon to follow link

MKK7 (mitogen-activated protein kinase kinase 7) Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

STE7 family. Accessed on 20/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=623.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.