Top ▲
Target not currently curated in GtoImmuPdb
Target id: 2037
Nomenclature: hormonally up-regulated Neu-associated kinase
Abbreviated Name: HUNK
Family: HUNK subfamily
Gene and Protein Information  |
||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 714 | 21q22.11 | HUNK | hormonally up-regulated Neu-associated kinase | |
| Mouse | - | 714 | 16 51.71 cM | Hunk | hormonally upregulated Neu-associated kinase | |
| Rat | - | 714 | 11 q11 | Hunk | hormonally upregulated Neu-associated kinase | |
| Previous and Unofficial Names |
| B19 | Bstk1 | MAK5 | Mak-v |
| Database Links |
|
| Alphafold | P57058 (Hs), O88866 (Mm) |
| BRENDA | 2.7.11.1 |
| ChEMBL Target | CHEMBL1795165 (Hs) |
| Ensembl Gene | ENSG00000142149 (Hs), ENSMUSG00000053414 (Mm), ENSRNOG00000002092 (Rn) |
| Entrez Gene | 30811 (Hs), 26559 (Mm), 288275 (Rn) |
| Human Protein Atlas | ENSG00000142149 (Hs) |
| KEGG Enzyme | 2.7.11.1 |
| KEGG Gene | hsa:30811 (Hs), mmu:26559 (Mm), rno:288275 (Rn) |
| OMIM | 606532 (Hs) |
| Pharos | P57058 (Hs) |
| RefSeq Nucleotide | NM_014586 (Hs), NM_015755 (Mm), NM_001191662 (Rn) |
| RefSeq Protein | NP_055401 (Hs), NP_056570 (Mm), NP_001178591 (Rn) |
| UniProtKB | P57058 (Hs), O88866 (Mm) |
| Wikipedia | HUNK (Hs) |
| Enzyme Reaction |
||||
|
||||
Download all structure-activity data for this target as a CSV file 
| Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||||||||||||||||||||||
| DiscoveRx KINOMEscan® screen |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3 |
 
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Target used in screen: HUNK | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Displaying the top 10 most potent ligands View all ligands in screen » | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Dilday T, Abt M, Ramos-Solís N, Dayal N, Larocque E, Oblak AL, Sintim HO, Yeh ES. (2024) Identification and characterization of a potent and selective HUNK inhibitor for treatment of HER2+ breast cancer. Cell Chem Biol, [Epub ahead of print]. [PMID:38307028]
3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
HUNK subfamily: hormonally up-regulated Neu-associated kinase. Last modified on 05/02/2024. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2037.
