aurora kinase C | Aurora kinase (Aur) family | IUPHAR/BPS Guide to PHARMACOLOGY

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aurora kinase C

Target not currently curated in GtoImmuPdb

Target id: 1938

Nomenclature: aurora kinase C

Abbreviated Name: AurC

Family: Aurora kinase (Aur) family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 309 19q13.3-qter AURKC aurora kinase C
Mouse - 315 7 A2-A3 Aurkc aurora kinase C
Rat - 111 1 q12 Aurkc aurora kinase C
Previous and Unofficial Names
AIK3 | ARK3 | Aurora 3 | serine/threonine-protein kinase 13 | STK13
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
GSK1070916 Hs Inhibition 8.8 pKi 1
pKi 8.8 (Ki 1.5x10-9 M) [1]
tozasertib Hs Inhibition 8.3 pKi 9
pKi 8.3 (Ki 4.6x10-9 M) [9]
AMG-900 Hs Inhibition 9.0 pIC50 10
pIC50 9.0 (IC50 1x10-9 M) [10]
ilorasertib Hs Inhibition 9.0 pIC50 8
pIC50 9.0 (IC50 1x10-9 M) [8]
Description: Measuring inhibition of kinase activity in a biochemical assay.
MK-5108 Hs Inhibition 7.9 pIC50 11
pIC50 7.9 (IC50 1.21x10-8 M) [11]
SU6656 Hs Inhibition 7.8 pIC50 3
pIC50 7.8 (IC50 1.7x10-8 M) [3]
danusertib Hs Inhibition 7.2 pIC50 6
pIC50 7.2 (IC50 6.1x10-8 M) [6]
compound 38 [PMID: 20817473] Hs Inhibition 7.2 pIC50 4
pIC50 7.2 (IC50 6.2x10-8 M) [4]
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 5,13

Key to terms and symbols Click column headers to sort
Target used in screen: AURKC
Ligand Sp. Type Action Value Parameter
axitinib Hs Inhibitor Inhibition 8.9 pKd
lestaurtinib