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Aurora kinase (Aur) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The three mammalian Aurora kinases (A, B and C) play essential roles cell division, by regulating mitosis and the cell cycle. These are evolutionarily conserved serine/threonine protein kinases, sharing a high degree of sequence homology, but with quite different subcellular distributions and functions [4,6,10]. Aurora kinases A and B are widely expressed in dividing cells, whereas Aurora kinase C expression appears to be restricted to the testes [9,15]. Their importance in the mitotic cycle has driven the development of Aurora kinase inhibitors as therapeutic antimitotic agents for both adult and childhood malignancies.


AurA (aurora kinase A) Show summary » More detailed page

AurB (aurora kinase B) Show summary » More detailed page

AurC (aurora kinase C) Show summary » More detailed page


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How to cite this family page

Database page citation:

Aurora kinase (Aur) family. Accessed on 24/10/2020. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.