Aurora kinase (Aur) family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The three mammalian Aurora kinases (A, B and C) play essential roles cell division, by regulating mitosis and the cell cycle. These are evolutionarily conserved serine/threonine protein kinases, sharing a high degree of sequence homology, but with quite different subcellular distributions and functions [4,6,10]. Aurora kinases A and B are widely expressed in dividing cells, whereas Aurora kinase C expression appears to be restricted to the testes [9,15]. Their importance in the mitotic cycle has driven the development of Aurora kinase inhibitors as therapeutic antimitotic agents for both adult and childhood malignancies.

Enzymes

AurA (aurora kinase A) Show summary » More detailed page

AurB (aurora kinase B) Show summary » More detailed page

AurC (aurora kinase C) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Aurora kinase (Aur) family. Accessed on 20/09/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=557.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.