Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	592	5q31.1	CDKL3	cyclin dependent kinase like 3
Mouse	-	595	11 B1.3	Cdkl3	cyclin dependent kinase like 3
Rat	-	593	10q22	Cdkl3	cyclin-dependent kinase-like 3

Previous and Unofficial Names

NKIAMRE | serine/threonine kinase NKIATRE | serine/threonine kinase NKIATRE beta

Database Links
Alphafold	Q8IVW4 (Hs), Q8BLF2 (Mm), Q9JM01 (Rn)
BRENDA	2.7.11.22
ChEMBL Target	CHEMBL1163117 (Hs)
Ensembl Gene	ENSG00000006837 (Hs), ENSMUSG00000020389 (Mm), ENSRNOG00000059485 (Rn)
Entrez Gene	51265 (Hs), 213084 (Mm), 60396 (Rn)
Human Protein Atlas	ENSG00000006837 (Hs)
KEGG Enzyme	2.7.11.22
KEGG Gene	hsa:51265 (Hs), mmu:213084 (Mm), rno:60396 (Rn)
OMIM	608459 (Hs)
Pharos	Q8IVW4 (Hs)
RefSeq Nucleotide	NM_001113575 (Hs), NM_001166653 (Mm), NM_021772 (Rn)
RefSeq Protein	NP_001107047 (Hs), NP_001160125 (Mm), NP_068540 (Rn)
UniProtKB	Q8IVW4 (Hs), Q8BLF2 (Mm), Q9JM01 (Rn)
Wikipedia	CDKL3 (Hs)

Enzyme Reaction
EC Number: 2.7.11.22

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: CDKL3
Ligand Sp. Type Action Value Parameter AST-487 Hs Inhibitor Inhibition 8.4 pKd tozasertib Hs Inhibitor Inhibition 6.5 pKd lestaurtinib Hs Inhibitor Inhibition 6.4 pKd sorafenib Hs Inhibitor Inhibition 6.3 pKd A-674563 Hs Inhibitor Inhibition 6.0 pKd BMS-387032 Hs Inhibitor Inhibition 5.8 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd erlotinib Hs Inhibitor Inhibition <5.5 pKd linifanib Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »