cyclin-dependent kinase like 3 | Cyclin-dependent kinase-like (CDKL) family | IUPHAR/BPS Guide to PHARMACOLOGY

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cyclin-dependent kinase like 3

Target not currently curated in GtoImmuPdb

Target id: 1984

Nomenclature: cyclin-dependent kinase like 3

Abbreviated Name: CdkL3

Family: Cyclin-dependent kinase-like (CDKL) family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 592 5q31 CDKL3 cyclin dependent kinase like 3
Mouse - 610 11 B1.3 Cdkl3 cyclin-dependent kinase-like 3
Rat - 457 10q22 Cdkl3 cyclin-dependent kinase-like 3
Previous and Unofficial Names
NKIAMRE | serine/threonine kinase NKIATRE | serine/threonine kinase NKIATRE beta
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: CDKL3
Ligand Sp. Type Action Value Parameter
AST-487 Hs Inhibitor Inhibition 8.4 pKd
tozasertib Hs Inhibitor Inhibition 6.5 pKd
lestaurtinib Hs Inhibitor Inhibition 6.4 pKd
sorafenib Hs Inhibitor Inhibition 6.3 pKd
A-674563 Hs Inhibitor Inhibition 6.0 pKd
BMS-387032 Hs Inhibitor Inhibition 5.8 pKd
SB203580 Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd
erlotinib Hs Inhibitor Inhibition <5.5 pKd
GSK690693 Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »


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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Cyclin-dependent kinase-like (CDKL) family: cyclin-dependent kinase like 3. Last modified on 29/01/2016. Accessed on 12/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY,