cyclin-dependent kinase like 3 | Cyclin-dependent kinase-like (CDKL) family | IUPHAR/BPS Guide to PHARMACOLOGY

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cyclin-dependent kinase like 3

Target not currently curated in GtoImmuPdb

Target id: 1984

Nomenclature: cyclin-dependent kinase like 3

Abbreviated Name: CdkL3

Family: Cyclin-dependent kinase-like (CDKL) family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 592 5q31 CDKL3 cyclin dependent kinase like 3
Mouse - 610 11 B1.3 Cdkl3 cyclin-dependent kinase-like 3
Rat - 457 10q22 Cdkl3 cyclin-dependent kinase-like 3
Previous and Unofficial Names
NKIAMRE | serine/threonine kinase NKIATRE | serine/threonine kinase NKIATRE beta
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: CDKL3
Ligand Sp. Type Action Value Parameter
AST-487 Hs Inhibitor Inhibition 8.4 pKd
tozasertib Hs Inhibitor Inhibition 6.5 pKd
lestaurtinib Hs Inhibitor Inhibition 6.4 pKd
sorafenib Hs Inhibitor Inhibition 6.3 pKd
A-674563 Hs Inhibitor Inhibition 6.0 pKd
BMS-387032 Hs Inhibitor Inhibition 5.8 pKd
SB203580 Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd
erlotinib Hs Inhibitor Inhibition <5.5 pKd
GSK690693 Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Cyclin-dependent kinase-like (CDKL) family: cyclin-dependent kinase like 3. Last modified on 29/01/2016. Accessed on 25/05/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1984.