cyclin dependent kinase 16 | TAIRE subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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cyclin dependent kinase 16

Target not currently curated in GtoImmuPdb

Target id: 1969

Nomenclature: cyclin dependent kinase 16

Abbreviated Name: CDK16

Family: TAIRE subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 496 Xp11 CDK16 cyclin dependent kinase 16
Mouse - 496 X A1.3 Cdk16 cyclin-dependent kinase 16
Rat - 496 Xq12 Cdk16 cyclin-dependent kinase 16
Previous and Unofficial Names
cell division protein kinase 16 | CRK5 | PCTAIRE protein kinase 1 | PCTAIRE1
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804
PDB Id:  3MTL
Resolution:  2.4Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: PCTK1
Ligand Sp. Type Action Value Parameter
R547 Hs Inhibitor Inhibition 9.3 pKd
AT-7519 Hs Inhibitor Inhibition 9.0 pKd
BMS-387032 Hs Inhibitor Inhibition 8.1 pKd
staurosporine Hs Inhibitor Inhibition 7.6 pKd
lestaurtinib Hs Inhibitor Inhibition 7.6 pKd
sunitinib Hs Inhibitor Inhibition 6.8 pKd
tozasertib Hs Inhibitor Inhibition 6.6 pKd
AST-487 Hs Inhibitor Inhibition 6.4 pKd
dovitinib Hs Inhibitor Inhibition 6.4 pKd
alvocidib Hs Inhibitor Inhibition 6.4 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

TAIRE subfamily: cyclin dependent kinase 16. Last modified on 22/03/2013. Accessed on 22/09/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1969.