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Target not currently curated in GtoImmuPdb
Target id: 2006
Nomenclature: doublecortin like kinase 2
Abbreviated Name: DCAMKL2
Family: DCAMKL family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 766 | 4q31.23-q31.3 | DCLK2 | doublecortin like kinase 2 | |
Mouse | - | 756 | 3 F1 | Dclk2 | doublecortin-like kinase 2 | |
Rat | - | 767 | 2q34 | Dclk2 | doublecortin-like kinase 2 |
Previous and Unofficial Names ![]() |
CaMK-like CREB regulatory kinase 2 | CLICK2 | CLICK-II | DCK2 | doublecortin and CaM kinase-like 2 |
Database Links ![]() |
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Alphafold | Q8N568 (Hs), Q6PGN3 (Mm), Q5MPA9 (Rn) |
BRENDA | 2.7.11.1 |
CATH/Gene3D | 3.10.20.230 |
ChEMBL Target | CHEMBL5519 (Hs) |
Ensembl Gene | ENSG00000170390 (Hs), ENSMUSG00000028078 (Mm), ENSRNOG00000016550 (Rn) |
Entrez Gene | 166614 (Hs), 70762 (Mm), 310698 (Rn) |
Human Protein Atlas | ENSG00000170390 (Hs) |
KEGG Enzyme | 2.7.11.1 |
KEGG Gene | hsa:166614 (Hs), mmu:70762 (Mm), rno:310698 (Rn) |
OMIM | 613166 (Hs) |
Pharos | Q8N568 (Hs) |
RefSeq Nucleotide | NM_001040260 (Hs), NM_001195496 (Mm), NM_001009691 (Rn) |
RefSeq Protein | NP_001035350 (Hs), NP_001182425 (Mm), NP_001009691 (Rn) |
UniProtKB | Q8N568 (Hs), Q6PGN3 (Mm), Q5MPA9 (Rn) |
Wikipedia | DCLK2 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,5 |
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Target used in screen: DCAMKL2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen ![]() |
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A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,4 |
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Target used in screen: DCAMKL2/DCAMKL2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
3. Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J et al.. (2020) Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol, 16 (6): 635-643. [PMID:32251410]
4. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]
5. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
6. Yang Q, Deng X, Lu B, Cameron M, Fearns C, Patricelli MP, Yates 3rd JR, Gray NS, Lee JD. (2010) Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell, 18 (3): 258-67. [PMID:20832753]
DCAMKL family: doublecortin like kinase 2. Last modified on 14/07/2020. Accessed on 16/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2006.