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Target not currently curated in GtoImmuPdb
Target id: 2007
Nomenclature: doublecortin like kinase 3
Abbreviated Name: DCAMKL3
Family: DCAMKL family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 648 | 3p22.2 | DCLK3 | doublecortin like kinase 3 | |
Mouse | - | 790 | 9 F3 | Dclk3 | doublecortin-like kinase 3 | |
Rat | - | 807 | 8 q32 | Dclk3 | doublecortin-like kinase 3 |
Previous and Unofficial Names ![]() |
doublecortin and CaM kinase-like 3 |
Database Links ![]() |
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Alphafold | Q9C098 (Hs), Q8BWQ5 (Mm) |
BRENDA | 2.7.11.1 |
ChEMBL Target | CHEMBL6123 (Hs) |
Ensembl Gene | ENSG00000163673 (Hs), ENSMUSG00000032500 (Mm), ENSRNOG00000033026 (Rn) |
Entrez Gene | 85443 (Hs), 245038 (Mm), 316023 (Rn) |
Human Protein Atlas | ENSG00000163673 (Hs) |
KEGG Enzyme | 2.7.11.1 |
KEGG Gene | hsa:85443 (Hs), mmu:245038 (Mm), rno:316023 (Rn) |
OMIM | 613167 (Hs) |
Pharos | Q9C098 (Hs) |
RefSeq Nucleotide | NM_033403 (Hs), NM_172928 (Mm), NM_001191800 (Rn) |
RefSeq Protein | NP_208382 (Hs), NP_766516 (Mm), NP_001178729 (Rn) |
UniProtKB | Q9C098 (Hs), Q8BWQ5 (Mm) |
Wikipedia | DCLK3 (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
1μM compound 5n [PMID 20483621] almost completely abolishes DCLK3 activity [2]. |
DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3 |
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Target used in screen: DCAMKL3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Milkiewicz KL, Weinberg LR, Albom MS, Angeles TS, Cheng M, Ghose AK, Roemmele RC, Theroff JP, Underiner TL, Zificsak CA et al.. (2010) Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem, 18 (12): 4351-62. [PMID:20483621]
3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
DCAMKL family: doublecortin like kinase 3. Last modified on 29/01/2016. Accessed on 09/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2007.