Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	508	2p16.1	VRK2	VRK serine/threonine kinase 2
Mouse	1	503	11 A3.3	Vrk2	vaccinia related kinase 2
Rat	-	229	14 q22	Vrk2	VRK serine/threonine kinase 2

Database Links
Alphafold	Q86Y07 (Hs), Q8BN21 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL1649059 (Hs)
Ensembl Gene	ENSG00000028116 (Hs), ENSMUSG00000064090 (Mm), ENSRNOG00000007864 (Rn)
Entrez Gene	7444 (Hs), 69922 (Mm), 360991 (Rn)
Human Protein Atlas	ENSG00000028116 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:7444 (Hs), mmu:69922 (Mm), rno:360991 (Rn)
OMIM	602169 (Hs)
Pharos	Q86Y07 (Hs)
RefSeq Nucleotide	NM_001130480 (Hs), NM_027260 (Mm), NM_001108366 (Rn)
RefSeq Protein	NP_001123952 (Hs), NP_081536 (Mm), NP_001101836 (Rn)
UniProtKB	Q86Y07 (Hs), Q8BN21 (Mm)
Wikipedia	VRK2 (Hs)

Selected 3D Structures
	Description:  Structure of VRK2. PDB Id:  2V62 Resolution:  1.7Å Species:  Human References:  3

Enzyme Reaction
EC Number: 2.7.11.1

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,4
Key to terms and symbols		Click column headers to sort
Target used in screen: VRK2
Ligand Sp. Type Action Value Parameter alvocidib Hs Inhibitor Inhibition 7.2 pKd bosutinib Hs Inhibitor Inhibition 6.2 pKd erlotinib Hs Inhibitor Inhibition <5.5 pKd GSK690693 Hs Inhibitor Inhibition <5.5 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd masitinib Hs Inhibitor Inhibition <5.5 pKd gefitinib Hs Inhibitor Inhibition <5.5 pKd linifanib Hs Inhibitor Inhibition <5.5 pKd crizotinib Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 2...
Key to terms and symbols		Click column headers to sort
Target used in screen: VRK2/nd
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM indirubin derivative E804 Hs Inhibitor Inhibition 69.0 26.0 compound 52 [PMID: 9677190] Hs Inhibitor Inhibition 71.0 19.0 indirubin-3'-monoxime Hs Inhibitor Inhibition 71.0 28.0 Flt-3 inhibitor II Hs Inhibitor Inhibition 72.0 37.0 PKR inhibitor Hs Inhibitor Inhibition 75.0 26.0 Cdk1 inhibitor Hs Inhibitor Inhibition 76.0 28.0 SP600125 Hs Inhibitor Inhibition 78.0 36.0 Cdk2 inhibitor III Hs Inhibitor Inhibition 79.0 46.0 IC261 Hs Inhibitor Inhibition 83.0 32.0 JAK3 inhibitor II Hs Inhibitor Inhibition 83.0 56.0
Displaying the top 10 most potent ligands  View all ligands in screen »

Immuno Process Associations

Immuno Process:  Cytokine production & signalling