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Target not currently curated in GtoImmuPdb
Target id: 2207
Nomenclature: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
Abbreviated Name: Srm
Family: Src family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 488 | 20q13.33 | SRMS | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | |
Mouse | - | 496 | 2 103.62 cM | Srms | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites | |
Rat | - | 507 | 3 q43 | Srms | src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites |
Previous and Unofficial Names ![]() |
SRM |
Database Links ![]() |
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Alphafold | Q9H3Y6 (Hs), Q62270 (Mm) |
BRENDA | 2.7.10.2 |
CATH/Gene3D | 3.30.505.10 |
ChEMBL Target | CHEMBL5703 (Hs) |
Ensembl Gene | ENSG00000125508 (Hs), ENSMUSG00000027579 (Mm), ENSRNOG00000013003 (Rn) |
Entrez Gene | 6725 (Hs), 20811 (Mm), 296472 (Rn) |
Human Protein Atlas | ENSG00000125508 (Hs) |
KEGG Enzyme | 2.7.10.2 |
KEGG Gene | hsa:6725 (Hs), mmu:20811 (Mm), rno:296472 (Rn) |
Pharos | Q9H3Y6 (Hs) |
RefSeq Nucleotide | NM_080823 (Hs), NM_011481 (Mm), NM_001011961 (Rn) |
RefSeq Protein | NP_543013 (Hs), NP_035611 (Mm), NP_001011961 (Rn) |
UniProtKB | Q9H3Y6 (Hs), Q62270 (Mm) |
Wikipedia | SRMS (Hs) |
Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
SRMS activity is inhibited by 98% in the presence of 1μM compound 66 [PMID 21802293] [3]. |
DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,4 |
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Target used in screen: SRMS | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen ![]() |
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A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1 |
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Target used in screen: nd/SRMS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
3. Wenglowsky S, Ahrendt KA, Buckmelter AJ, Feng B, Gloor SL, Gradl S, Grina J, Hansen JD, Laird ER, Lunghofer P et al.. (2011) Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships. Bioorg Med Chem Lett, 21 (18): 5533-7. [PMID:21802293]
4. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
Src family: src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites. Last modified on 24/02/2015. Accessed on 06/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2207.