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Target not currently curated in GtoImmuPdb
Target id: 1538
Nomenclature: serine/threonine kinase 32B
Abbreviated Name: YANK2
Family: YANK family
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 414 | 4p16.2 | STK32B | serine/threonine kinase 32B | |
| Mouse | - | 414 | 5 B3 | Stk32b | serine/threonine kinase 32B | |
| Rat | - | 414 | 14q21 | Stk32b | serine/threonine kinase 32B | |
| Previous and Unofficial Names |
| STK32 | STKG6 |
| Database Links |
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| Alphafold | Q9NY57 (Hs), Q9JJX8 (Mm) |
| BRENDA | 2.7.11.1 |
| ChEMBL Target | CHEMBL5912 (Hs) |
| Ensembl Gene | ENSG00000152953 (Hs), ENSMUSG00000029123 (Mm), ENSRNOG00000031397 (Rn) |
| Entrez Gene | 55351 (Hs), 64293 (Mm), 305431 (Rn) |
| Human Protein Atlas | ENSG00000152953 (Hs) |
| KEGG Enzyme | 2.7.11.1 |
| KEGG Gene | hsa:55351 (Hs), mmu:64293 (Mm), rno:305431 (Rn) |
| Pharos | Q9NY57 (Hs) |
| RefSeq Nucleotide | NM_018401 (Hs), NM_022416 (Mm), NM_001107224 (Rn) |
| RefSeq Protein | NP_060871 (Hs), NP_071861 (Mm), NP_001100694 (Rn) |
| UniProtKB | Q9NY57 (Hs), Q9JJX8 (Mm) |
| Wikipedia | STK32B (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||
| STK32B activity is completely abolished in the presence of 1μM compound 74 [PMID 24793884] [2] (note that STK32B is referred to by its synonym YANK2 in the article's Supplementary data table).. | |||||||||||||||||||||||||||||||||||||||||||||||||||
| DiscoveRx KINOMEscan® screen |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3 |
 
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| Target used in screen: YANK2 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Displaying the top 10 most potent ligands View all ligands in screen » | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Reichelt A, Bailis JM, Bartberger MD, Yao G, Shu H, Kaller MR, Allen JG, Weidner MF, Keegan KS, Dao JH. (2014) Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem, 80: 364-82. [PMID:24793884]
3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
YANK family: serine/threonine kinase 32B. Last modified on 25/02/2015. Accessed on 31/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1538.
