Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	587	18q21.1-q21.2	MAPK4	mitogen-activated protein kinase 4
Mouse	-	583	18 E2	Mapk4	mitogen-activated protein kinase 4
Rat	-	274	18q12.2	Mapk4	mitogen-activated protein kinase 4

Previous and Unofficial Names

MAP kinase 4 | MNK2 | p63Mapk | PRKM4

Database Links
Alphafold	P31152 (Hs), Q6P5G0 (Mm), Q63454 (Rn)
BRENDA	2.7.11.24
ChEMBL Target	CHEMBL5759 (Hs)
Ensembl Gene	ENSG00000141639 (Hs), ENSMUSG00000024558 (Mm), ENSRNOG00000015401 (Rn)
Entrez Gene	5596 (Hs), 225724 (Mm), 54268 (Rn)
Human Protein Atlas	ENSG00000141639 (Hs)
KEGG Enzyme	2.7.11.24
KEGG Gene	hsa:5596 (Hs), mmu:225724 (Mm), rno:54268 (Rn)
OMIM	176949 (Hs)
Pharos	P31152 (Hs)
RefSeq Nucleotide	NM_002747 (Hs), NM_172632 (Mm), NM_019319 (Rn)
RefSeq Protein	NP_002738 (Hs), NP_766220 (Mm), NP_062192 (Rn)
UniProtKB	P31152 (Hs), Q6P5G0 (Mm), Q63454 (Rn)
Wikipedia	MAPK4 (Hs)

Enzyme Reaction
EC Number: 2.7.11.24

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: ERK4
Ligand Sp. Type Action Value Parameter PD-173955 Hs Inhibitor Inhibition 6.0 pKd erlotinib Hs Inhibitor Inhibition 5.6 pKd ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd GSK690693 Hs Inhibitor Inhibition <5.5 pKd A-674563 Hs Inhibitor Inhibition <5.5 pKd SB203580 Hs Inhibitor Inhibition <5.5 pKd crizotinib Hs Inhibitor Inhibition <5.5 pKd masitinib Hs Inhibitor Inhibition <5.5 pKd linifanib Hs Inhibitor Inhibition <5.5 pKd staurosporine Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »