RIO kinase 3 | RIO3 subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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RIO kinase 3

Target not currently curated in GtoImmuPdb

Target id: 2188

Nomenclature: RIO kinase 3

Abbreviated Name: RIOK3

Family: RIO3 subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 519 18q11.2 RIOK3 RIO kinase 3
Mouse - 519 18 A2 Riok3 RIO kinase 3
Rat - 519 18 p13 Riok3 RIO kinase 3
Previous and Unofficial Names
SUDD
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: RIOK3
Ligand Sp. Type Action Value Parameter
lestaurtinib Hs Inhibitor Inhibition 8.1 pKd
KW-2449 Hs Inhibitor Inhibition 7.2 pKd
staurosporine Hs Inhibitor Inhibition 7.1 pKd
fedratinib Hs Inhibitor Inhibition 7.0 pKd
tamatinib Hs Inhibitor Inhibition 6.7 pKd
PHA-665752 Hs Inhibitor Inhibition 6.4 pKd
midostaurin Hs Inhibitor Inhibition 6.4 pKd
tozasertib Hs Inhibitor Inhibition 6.2 pKd
ruboxistaurin Hs Inhibitor Inhibition 6.2 pKd
A-674563 Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

RIO3 subfamily: RIO kinase 3. Last modified on 18/08/2014. Accessed on 14/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2188.