RIO kinase 3 | RIO3 subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

RIO kinase 3

Target not currently curated in GtoImmuPdb

Target id: 2188

Nomenclature: RIO kinase 3

Abbreviated Name: RIOK3

Family: RIO3 subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 519 18q11.2 RIOK3 RIO kinase 3
Mouse - 519 18 A2 Riok3 RIO kinase 3
Rat - 519 18 p13 Riok3 RIO kinase 3
Previous and Unofficial Names
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: RIOK3
Ligand Sp. Type Action Value Parameter
lestaurtinib Hs Inhibitor Inhibition 8.1 pKd
KW-2449 Hs Inhibitor Inhibition 7.2 pKd
staurosporine Hs Inhibitor Inhibition 7.1 pKd
fedratinib Hs Inhibitor Inhibition 7.0 pKd
tamatinib Hs Inhibitor Inhibition 6.7 pKd
PHA-665752 Hs Inhibitor Inhibition 6.4 pKd
midostaurin Hs Inhibitor Inhibition 6.4 pKd
tozasertib Hs Inhibitor Inhibition 6.2 pKd
ruboxistaurin Hs Inhibitor Inhibition 6.2 pKd
A-674563 Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »


Show »

1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

RIO3 subfamily: RIO kinase 3. Last modified on 18/08/2014. Accessed on 14/12/2019. IUPHAR/BPS Guide to PHARMACOLOGY,