Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	387	7p11.2	PHKG1	phosphorylase kinase catalytic subunit gamma 1
Mouse	-	388	5 68.26 cM	Phkg1	phosphorylase kinase gamma 1
Rat	-	388	12q13	Phkg1	phosphorylase kinase catalytic subunit gamma 1

Previous and Unofficial Names

gamma phosphorylase kinase | HK-gamma-M | PHKIN01 | phosphorylase kinase, gamma 1 (muscle) | phosphorylase kinase gamma subunit 1 | phosphorylase kinase

Database Links
Alphafold	Q16816 (Hs), P07934 (Mm), P13286 (Rn)
BRENDA	2.7.11.19
ChEMBL Target	CHEMBL4004 (Hs)
Ensembl Gene	ENSG00000164776 (Hs), ENSMUSG00000025537 (Mm), ENSRNOG00000000920 (Rn)
Entrez Gene	5260 (Hs), 18682 (Mm), 29353 (Rn)
Human Protein Atlas	ENSG00000164776 (Hs)
KEGG Enzyme	2.7.11.19
KEGG Gene	hsa:5260 (Hs), mmu:18682 (Mm), rno:29353 (Rn)
OMIM	172470 (Hs)
Orphanet	ORPHA352609 (Hs)
Pharos	Q16816 (Hs)
RefSeq Nucleotide	NM_001258459 (Hs), NM_011079 (Mm), NM_031573 (Rn)
RefSeq Protein	NP_006204 (Hs), NP_035209 (Mm), NP_113761 (Rn)
UniProtKB	Q16816 (Hs), P07934 (Mm), P13286 (Rn)
Wikipedia	PHKG1 (Hs)

Enzyme Reaction
EC Number: 2.7.11.19

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference A-443654 Hs Inhibition - - 3 ⤷ [3] Description: Measured as % inhibition using 1μM compound.
Inhibitor Comments
A-443654 inhibits PHKG1 activity by approximately 76% using 1μM compound [3].

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 2,4
Key to terms and symbols		Click column headers to sort
Target used in screen: PHKG1
Ligand Sp. Type Action Value Parameter lestaurtinib Hs Inhibitor Inhibition 9.4 pKd staurosporine Hs Inhibitor Inhibition 9.2 pKd sunitinib Hs Inhibitor Inhibition 8.3 pKd NVP-TAE684 Hs Inhibitor Inhibition 7.8 pKd SU-14813 Hs Inhibitor Inhibition 7.1 pKd KW-2449 Hs Inhibitor Inhibition 6.7 pKd fedratinib Hs Inhibitor Inhibition 6.5 pKd bosutinib Hs Inhibitor Inhibition 6.5 pKd JNJ-28312141 Hs Inhibitor Inhibition 6.2 pKd dovitinib Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: ...1
Key to terms and symbols		Click column headers to sort
Target used in screen: nd/PHKg1
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM K-252a Hs Inhibitor Inhibition 1.2 staurosporine Hs Inhibitor Inhibition 1.4 Gö 6976 Hs Inhibitor Inhibition 1.8 midostaurin Hs Inhibitor Inhibition 2.3 SB 218078 Hs Inhibitor Inhibition 2.7 SU11652 Hs Inhibitor Inhibition 3.2 sunitinib Hs Inhibitor Inhibition 5.1 alsterpaullone 2-cyanoethyl Hs Inhibitor Inhibition 7.7 indirubin derivative E804 Hs Inhibitor Inhibition 8.1 alsterpaullone Hs Inhibitor Inhibition 9.2
Displaying the top 10 most potent ligands  View all ligands in screen »

Clinically-Relevant Mutations and Pathophysiology
Disease:  Glycogen storage disease due to muscle phosphorylase kinase deficiency Synonyms: Glycogen storage disease IX [Disease Ontology: DOID:0050594] Disease Ontology: DOID:0050594 Orphanet: ORPHA715