Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	388	6p25.2	MYLK4	myosin light chain kinase family member 4
Mouse	-	386	13 A3.2	Mylk4	myosin light chain kinase family, member 4

Previous and Unofficial Names

Sugen kinase 85 | myosin light chain kinase family, member 4 | myosin light chain kinase family

Database Links
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL5426 (Hs)
Ensembl Gene	ENSG00000145949 (Hs), ENSMUSG00000044951 (Mm)
Entrez Gene	340156 (Hs), 238564 (Mm)
Human Protein Atlas	ENSG00000145949 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:340156 (Hs), mmu:238564 (Mm)
Pharos	Q86YV6 (Hs)
RefSeq Nucleotide	NM_001012418 (Hs), NM_001166030 (Mm)
RefSeq Protein	NP_001012418 (Hs), NP_001159502 (Mm)
UniProtKB	Q86YV6 (Hs), Q5SUV5 (Mm)
Wikipedia	MYLK4 (Hs)

Selected 3D Structures
	Description:  The Crystal Structure of the human myosin light chain kinase LOC340156. PDB Id:  2X4F Resolution:  2.67Å Species:  Human References:

Enzyme Reaction
EC Number: 2.7.11.1

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: MYLK4
Ligand Sp. Type Action Value Parameter sunitinib Hs Inhibitor Inhibition 7.8 pKd lestaurtinib Hs Inhibitor Inhibition 7.5 pKd SU-14813 Hs Inhibitor Inhibition 7.5 pKd dovitinib Hs Inhibitor Inhibition 7.1 pKd fedratinib Hs Inhibitor Inhibition 6.9 pKd KW-2449 Hs Inhibitor Inhibition 6.8 pKd enzastaurin Hs Inhibitor Inhibition 6.6 pKd staurosporine Hs Inhibitor Inhibition 6.3 pKd midostaurin Hs Inhibitor Inhibition 6.2 pKd BMS-345541 Hs Inhibitor Inhibition 6.2 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »