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Target not currently curated in GtoImmuPdb
Target id: 2111
Nomenclature: myosin light chain kinase family member 4
Abbreviated Name: Sgk085
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 388 | 6p25.2 | MYLK4 | myosin light chain kinase family member 4 | |
Mouse | - | 386 | 13 A3.2 | Mylk4 | myosin light chain kinase family, member 4 |
Previous and Unofficial Names ![]() |
Sugen kinase 85 | myosin light chain kinase family, member 4 | myosin light chain kinase family |
Database Links ![]() |
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BRENDA | 2.7.11.1 |
ChEMBL Target | CHEMBL5426 (Hs) |
Ensembl Gene | ENSG00000145949 (Hs), ENSMUSG00000044951 (Mm) |
Entrez Gene | 340156 (Hs), 238564 (Mm) |
Human Protein Atlas | ENSG00000145949 (Hs) |
KEGG Enzyme | 2.7.11.1 |
KEGG Gene | hsa:340156 (Hs), mmu:238564 (Mm) |
Pharos | Q86YV6 (Hs) |
RefSeq Nucleotide | NM_001012418 (Hs), NM_001166030 (Mm) |
RefSeq Protein | NP_001012418 (Hs), NP_001159502 (Mm) |
UniProtKB | Q86YV6 (Hs), Q5SUV5 (Mm) |
Wikipedia | MYLK4 (Hs) |
Selected 3D Structures ![]() |
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Enzyme Reaction ![]() |
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DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2 |
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Target used in screen: MYLK4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]
2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]
Myosin Light Chain Kinase (MLCK) family: myosin light chain kinase family member 4. Last modified on 29/01/2016. Accessed on 23/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2111.