Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	469	7q21.13	CDK14	cyclin dependent kinase 14
Mouse	-	469	5 A1	Cdk14	cyclin dependent kinase 14
Rat	-	279	4q12-q13	Cdk14	cyclin-dependent kinase 14

Previous and Unofficial Names

cell division protein kinase 14 | PFTAIRE protein kinase 1 | PFTAIRE1 | PFTK1

Database Links
Alphafold	O94921 (Hs), O35495 (Mm)
BRENDA	2.7.11.22
ChEMBL Target	CHEMBL6162 (Hs)
Ensembl Gene	ENSG00000058091 (Hs), ENSMUSG00000028926 (Mm), ENSRNOG00000007151 (Rn)
Entrez Gene	5218 (Hs), 18647 (Mm), 362316 (Rn)
Human Protein Atlas	ENSG00000058091 (Hs)
KEGG Enzyme	2.7.11.22
KEGG Gene	hsa:5218 (Hs), mmu:18647 (Mm), rno:362316 (Rn)
OMIM	610679 (Hs)
Pharos	O94921 (Hs)
RefSeq Nucleotide	NM_012395 (Hs), NM_011074 (Mm), NM_001108617 (Rn)
RefSeq Protein	NP_036527 (Hs), NP_035204 (Mm), NP_001102087 (Rn)
UniProtKB	O94921 (Hs), O35495 (Mm)
Wikipedia	CDK14 (Hs)

Enzyme Reaction
EC Number: 2.7.11.22

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2
Key to terms and symbols		Click column headers to sort
Target used in screen: PFTK1
Ligand Sp. Type Action Value Parameter R547 Hs Inhibitor Inhibition 8.0 pKd AT-7519 Hs Inhibitor Inhibition 7.8 pKd AST-487 Hs Inhibitor Inhibition 7.8 pKd foretinib Hs Inhibitor Inhibition 7.5 pKd alvocidib Hs Inhibitor Inhibition 7.0 pKd staurosporine Hs Inhibitor Inhibition 6.8 pKd sunitinib Hs Inhibitor Inhibition 6.6 pKd BMS-387032 Hs Inhibitor Inhibition 6.2 pKd lestaurtinib Hs Inhibitor Inhibition 6.1 pKd A-674563 Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »