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ChEMBL ligand: CHEMBL237589 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
GtoPdb | Inhibition of human FPPS, measured through inhibition of tumour cell growth in NCI-H460 cell line . Not a direct enzyme inhibition assay. | - | 6.5 | pIC50 | - | - | - | J Med Chem (2007) 50: 6067-79 [PMID:17963374] |
ChEMBL | Inhibition of human FPPS | B | 6.6 | pIC50 | 251.19 | nM | IC50 | J Med Chem (2007) 50: 6067-6079 [PMID:17963374] |
ChEMBL | Inhibition of human FPPS | B | 6.62 | pIC50 | 240 | nM | IC50 | J Med Chem (2007) 50: 6067-6079 [PMID:17963374] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]