ChEMBL ligand: CHEMBL19902 (DX-9065A)
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] Coagulation factor X in Bovine [ChEMBL: CHEMBL3656] [UniProtKB: P00743] Coagulation factor X in Rabbit [ChEMBL: CHEMBL5062] [UniProtKB: O19045] There should be some charts here, you may need to enable JavaScript!
plasminogen/Plasminogen in Human [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] There should be some charts here, you may need to enable JavaScript!
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] There should be some charts here, you may need to enable JavaScript!
serine protease 1/Trypsin I in Human [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477] Trypsin I in Bovine [ChEMBL: CHEMBL3769] [UniProtKB: P00760] There should be some charts here, you may need to enable JavaScript!
Trypsin II in Bovine [ChEMBL: CHEMBL4472] [UniProtKB: Q29463] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Inhibition of factor 10a in human plasma	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4682-4687 [PMID:18667303]
ChEMBL	Inhibitory concentration against human Coagulation factor Xa (fXa)	B	7.39	pKi	41	nM	Ki	J Med Chem (2002) 45: 1221-1232 [PMID:11881991]
ChEMBL	Binding affinity against Coagulation factor X	B	7.39	pKi	41	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of Factor Xa	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2813-2818
ChEMBL	Inhibition of factor 10a	B	7.39	pKi	41	nM	Ki	J Med Chem (2010) 53: 6243-6274 [PMID:20503967]
ChEMBL	Inhibition of human factor 10a by Lineweaver-Burke plot	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2009) 17: 1193-1206 [PMID:19128974]
GtoPdb	Dissociation constant for FXa	-	7.39	pKi	41	nM	Ki	J Thromb Haemost (2004) 2: 612-8 [PMID:15102016]; Thromb Haemost (1994) 71: 314-9 [PMID:8029795]
ChEMBL	In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.	B	7.4	pKi	40	nM	Ki	J Med Chem (1999) 42: 5415-5425 [PMID:10639283]
ChEMBL	Compound was tested for inhibition activity against factor Xa (FXa)	B	7.66	pKi	22	nM	Ki	J Med Chem (1999) 42: 1749-1756 [PMID:10346927]
ChEMBL	Binding affinity towards Coagulation factor X	B	8.15	pKi	7	nM	Ki	J Med Chem (1998) 41: 4240-4250 [PMID:9784099]
ChEMBL	Inhibition of human factor 10a	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2008) 16: 2243-2260 [PMID:18077174]
ChEMBL	Inhibition of human factor 10a	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2008) 16: 3125-3140 [PMID:18164204]
ChEMBL	In vitro evaluation for the concentration needed for inhibiting factor Xa by 50%	B	7.15	pIC50	70	nM	IC50	J Med Chem (1994) 37: 1200-1207 [PMID:8164262]
ChEMBL	Inhibitory Activity against human Coagulation factor X	B	7.15	pIC50	70	nM	IC50	J Med Chem (2000) 43: 3033-3044 [PMID:10956211]
ChEMBL	Inhibition of human factor 10a	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2009) 17: 1193-1206 [PMID:19128974]
ChEMBL	Inhibition of human factor 10a	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2007) 15: 4175-4192 [PMID:17416533]
Coagulation factor X in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3656] [UniProtKB: P00743]
ChEMBL	Binding affinity towards Coagulation factor X	B	7.39	pKi	41	nM	Ki	J Med Chem (1998) 41: 4240-4250 [PMID:9784099]
Coagulation factor X in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5062] [UniProtKB: O19045]
ChEMBL	Compound was tested for the inhibition of serine protease factor Xa enzyme.	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem Lett (1998) 8: 3143-3148 [PMID:9873692]
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL	Inhibition of human plasmin by Lineweaver-Burke plot	B	4.64	pKi	23000	nM	Ki	Bioorg Med Chem (2009) 17: 1193-1206 [PMID:19128974]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Compound was tested for inhibition activity against human thrombin (FIIa)	B	5.3	pKi	>5000	nM	Ki	J Med Chem (1999) 42: 1749-1756 [PMID:10346927]
ChEMBL	Inhibitory concentration against thrombin.	B	5.7	pKi	>2000	nM	Ki	J Med Chem (2002) 45: 1221-1232 [PMID:11881991]
ChEMBL	Inhibition of human thrombin	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2007) 15: 4175-4192 [PMID:17416533]
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750]
ChEMBL	Inhibition of human recombinant tissue plasminogen activator by Lineweaver-Burke plot	B	4.68	pKi	21000	nM	Ki	Bioorg Med Chem (2009) 17: 1193-1206 [PMID:19128974]
serine protease 1/Trypsin I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477]
ChEMBL	Binding affinity against Trypsin	B	6.21	pKi	620	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760]
ChEMBL	Inhibitory concentration against bovine trypsin	B	6.2	pKi	630	nM	Ki	J Med Chem (2002) 45: 1221-1232 [PMID:11881991]
ChEMBL	Compound was tested for inhibition activity against bovine trypsin.	B	6.72	pKi	190	nM	Ki	J Med Chem (1999) 42: 1749-1756 [PMID:10346927]
Trypsin II in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4472] [UniProtKB: Q29463]
ChEMBL	Binding affinity towards Trypsin.	B	6.21	pKi	620	nM	Ki	J Med Chem (1998) 41: 4240-4250 [PMID:9784099]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]