ChEMBL ligand: CHEMBL19902 (DX-9065A)
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] Coagulation factor X in Bovine [ChEMBL: CHEMBL3656] [UniProtKB: P00743] Coagulation factor X in Rabbit [ChEMBL: CHEMBL5062] [UniProtKB: O19045] There should be some charts here, you may need to enable JavaScript!
plasminogen/Plasminogen in Human [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] There should be some charts here, you may need to enable JavaScript!
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] There should be some charts here, you may need to enable JavaScript!
serine protease 1/Trypsin I in Human [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477] Trypsin I in Bovine [ChEMBL: CHEMBL3769] [UniProtKB: P00760] There should be some charts here, you may need to enable JavaScript!
Trypsin II in Bovine [ChEMBL: CHEMBL4472] [UniProtKB: Q29463] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Inhibition of factor 10a in human plasma	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4682-4687 [PMID:18667303]
ChEMBL	Inhibitory concentration against human Coagulation factor Xa (fXa)	B	7.39	pKi	41	nM	Ki	J Med Chem (2002) 45: 1221-1232 [PMID:11881991]
ChEMBL	Binding affinity against Coagulation factor X	B	7.39	pKi	41	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	Inhibition of Factor Xa	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem Lett (1997) 7: 2813-2818
ChEMBL	Inhibition of factor 10a	B	7.39	pKi	41	nM	Ki	J Med Chem (2010) 53: 6243-6274 [PMID:20503967]
ChEMBL	Inhibition of human factor 10a by Lineweaver-Burke plot	B	7.39	pKi	41	nM	Ki	Bioorg Med Chem (2009) 17: 1193-1206 [PMID:19128974]
GtoPdb	Dissociation constant for FXa	-	7.39	pKi	41	nM	Ki	J Thromb Haemost (2004) 2: 612-8 [PMID:15102016]; Thromb Haemost (1994) 71: 314-9 [PMID:8029795]
ChEMBL	In vitro inhibition of human coagulation factor Xa (Xa) in a purified enzyme system.	B	7.4	pKi	40	nM	Ki	J Med Chem (1999) 42: 5415-5425 [PMID:10639283]
ChEMBL	Compound was tested for inhibition activity against factor Xa (FXa)	B	7.66	pKi	22	nM	Ki	J Med Chem (1999) 42: 1749-1756 [PMID:10346927]
ChEMBL	Binding affinity towards Coagulation factor X	B	8.15	pKi	7	nM	Ki	J Med Chem (1998) 41: 4240-4250 [PMID:9784099]
ChEMBL	Inhibition of human factor 10a	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2008) 16: 2243-2260 [PMID:18077174]
ChEMBL	Inhibition of human factor 10a	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2008) 16: 3125-3140 [PMID:18164204]
ChEMBL	In vitro evaluation for the concentration needed for inhibiting factor Xa by 50%	B	7.15	pIC50	70	nM	IC50	J Med Chem (1994) 37: 1200-1207 [PMID:8164262]
ChEMBL	Inhibitory Activity against human Coagulation factor X	B	7.15	pIC50	70	nM	IC50	J Med Chem (2000) 43: 3033-3044 [PMID:10956211]
ChEMBL	Inhibition of human factor 10a	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2009) 17: 1193-1206 [PMID:19128974]
ChEMBL	Inhibition of human factor 10a	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2007) 15: 4175-4192 [PMID:17416533]
Coagulation factor X in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3656] [UniProtKB: P00743]
ChEMBL	Binding affinity towards Coagulation factor X	B	7.39	pKi	41	nM	Ki	J Med Chem (1998) 41: 4240-4250 [PMID:9784099]
Coagulation factor X in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5062] [UniProtKB: O19045]
ChEMBL	Compound was tested for the inhibition of serine protease factor Xa enzyme.	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem Lett (1998) 8: 3143-3148 [PMID:9873692]
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL	Inhibition of human plasmin by Lineweaver-Burke plot	B	4.64	pKi	23000	nM	Ki	Bioorg Med Chem (2009) 17: 1193-1206 [PMID:19128974]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Compound was tested for inhibition activity against human thrombin (FIIa)	B	5.3	pKi	>5000	nM	Ki	J Med Chem (1999) 42: 1749-1756 [PMID:10346927]
ChEMBL	Inhibitory concentration against thrombin.	B	5.7	pKi	>2000	nM	Ki	J Med Chem (2002) 45: 1221-1232 [PMID:11881991]
ChEMBL	Inhibition of human thrombin	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2007) 15: 4175-4192 [PMID:17416533]
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750]
ChEMBL	Inhibition of human recombinant tissue plasminogen activator by Lineweaver-Burke plot	B	4.68	pKi	21000	nM	Ki	Bioorg Med Chem (2009) 17: 1193-1206 [PMID:19128974]
serine protease 1/Trypsin I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL209] [GtoPdb: 2397] [UniProtKB: P07477]
ChEMBL	Binding affinity against Trypsin	B	6.21	pKi	620	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760]
ChEMBL	Inhibitory concentration against bovine trypsin	B	6.2	pKi	630	nM	Ki	J Med Chem (2002) 45: 1221-1232 [PMID:11881991]
ChEMBL	Compound was tested for inhibition activity against bovine trypsin.	B	6.72	pKi	190	nM	Ki	J Med Chem (1999) 42: 1749-1756 [PMID:10346927]
Trypsin II in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4472] [UniProtKB: Q29463]
ChEMBL	Binding affinity towards Trypsin.	B	6.21	pKi	620	nM	Ki	J Med Chem (1998) 41: 4240-4250 [PMID:9784099]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]