GNE684 [Ligand Id: 13107] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL5208359 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| RalA-binding protein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5169159] [UniProtKB: Q62172] | ||||||||
| ChEMBL | Inhibition of mouse RIP1 | B | 6.72 | pIC50 | 189 | nM | IC50 | J Med Chem (2022) 65: 14971-14999 [PMID:36346971] |
| receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546] | ||||||||
| GtoPdb | - | - | 7.68 | pKi | 21 | nM | Ki | Cell Death Differ (2020) 27: 161-175 [PMID:31101885] |
| ChEMBL | Inhibition of human RIP1 | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2022) 65: 14971-14999 [PMID:36346971] |
| receptor interacting serine/threonine kinase 1 in Mouse [GtoPdb: 2189] [UniProtKB: Q60855] | ||||||||
| GtoPdb | - | - | 6.72 | pKi | 189 | nM | Ki | Cell Death Differ (2020) 27: 161-175 [PMID:31101885] |
| receptor interacting serine/threonine kinase 1 in Rat [GtoPdb: 2189] | ||||||||
| GtoPdb | - | - | 6.16 | pKi | 691 | nM | Ki | Cell Death Differ (2020) 27: 161-175 [PMID:31101885] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
