G4120   Click here for help

GtoPdb Ligand ID: 6588

Synonyms: cyclic Arg-Gly-Asp-containing pentapeptide | cyclic RGD | G 4120 | G-4120 | L-cysteine, N-(mercaptoacetyl)-D-tyrosyl-L-arginylglycyl-L-alpha- aspartyl-cyclic(1-->5)-sulfide, 5-oxide
Comment: G4120 is a synthetic Arg-Gly-Asp (RGD) containing peptide which potently inhibits platelet aggregation by antagonising fibrinogen binding to integrin αIIbβ3.
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES SCC(C(=O)O)NC(=O)C(CC(=O)O)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccc(cc1)O)N)CCCN=C(N)N
Isomeric SMILES SC[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)O)N)CCCN=C(N)N
InChI InChI=1S/C24H36N8O9S/c25-14(8-12-3-5-13(33)6-4-12)20(37)31-15(2-1-7-28-24(26)27)21(38)29-10-18(34)30-16(9-19(35)36)22(39)32-17(11-42)23(40)41/h3-6,14-17,33,42H,1-2,7-11,25H2,(H,29,38)(H,30,34)(H,31,37)(H,32,39)(H,35,36)(H,40,41)(H4,26,27,28)/t14-,15-,16-,17-/m0/s1
InChI Key BIEZITROCMXFHL-QAETUUGQSA-N
Classification Click here for help
Compound class Peptide or derivative
Synonyms Click here for help
cyclic Arg-Gly-Asp-containing pentapeptide | cyclic RGD | G 4120 | G-4120 | L-cysteine, N-(mercaptoacetyl)-D-tyrosyl-L-arginylglycyl-L-alpha- aspartyl-cyclic(1-->5)-sulfide, 5-oxide
Database Links Click here for help
CAS Registry No. 143120-27-8 (source: Scifinder)
GtoPdb PubChem SID 178103201
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