Synonyms: IAG-933 | NVP-IAG933
Compound class:
Synthetic organic
Comment: IAG933 is a small molecule that inhibits the protein-protein interaction (PPI) between YAP/TAZ and TEAD [1], as a route to inhibit oncogenic activation of the Hippo pathway [2]. IAG933 binds with high-affinity to the TEAD pocket (of all TEAD paralogs) that participates in formation of the YAP/TAZ-TEAD PPI.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
4-[(2S)-5-chloro-6-fluoro-2-phenyl-2-[(2S)-pyrrolidin-2-yl]-3H-1-benzofuran-4-yl]-5-fluoro-6-(2-hydroxyethoxy)-N-methylpyridine-3-carboxamide |
Synonyms ![]() |
IAG-933 | NVP-IAG933 |
Database Links ![]() |
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CAS Registry No. | 2714434-21-4 (source: PubChem) |
GtoPdb PubChem SID | 496703337 |
PubChem CID | 156855755 |
RCSB PDB Ligand | WCF |
Search Google for chemical match using the InChIKey | HUVOYQMXUNTUAI-DCFHFQCYSA-N |
Search Google for chemicals with the same backbone | HUVOYQMXUNTUAI |
UniChem Compound Search for chemical match using the InChIKey | HUVOYQMXUNTUAI-DCFHFQCYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | HUVOYQMXUNTUAI-DCFHFQCYSA-N |