ChEMBL ligand: CHEMBL322970 (SB-415286)
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7]
ChEMBL	Inhibition of CDK1/cyclinB	B	6.05	pIC50	900	nM	IC50	Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396]
ChEMBL	Inhibition of Cyclin-dependent kinase 2-cyclin A	B	6.42	pIC50	380	nM	IC50	J Med Chem (2003) 46: 3333-3341 [PMID:12852764]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL	Inhibitory concentration was determined against human glycogen synthase kinase-3 alpha	B	6.98	pIC50	104	nM	IC50	Bioorg Med Chem Lett (2001) 11: 635-639 [PMID:11266159]
ChEMBL	Inhibition of GSK3alpha	B	7.11	pIC50	78	nM	IC50	Trends Pharmacol Sci (2004) 25: 471-480 [PMID:15559249]
GtoPdb	-	-	7.42	pIC50	38	nM	IC50	Chem Biol (2000) 7: 793-803 [PMID:11033082]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of GSK3-beta assessed as NADH level after 10 mins by pyruvate kinase/lactate dehydrogenase coupled spectrophotometric assay	B	7.62	pKi	24	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1661-1664 [PMID:20138514]
ChEMBL	Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP	B	6.42	pIC50	380	nM	IC50	J Med Chem (2003) 46: 3333-3341 [PMID:12852764]
ChEMBL	Inhibition of recombinant GSK3-beta	B	6.98	pIC50	104	nM	IC50	J Med Chem (2008) 51: 2062-2077 [PMID:18324764]
ChEMBL	Inhibition of GSK3-beta by luminescent assay	B	7.05	pIC50	90	nM	IC50	J Nat Prod (2011) 74: 99-101 [PMID:21126094]
ChEMBL	Inhibition of human GSK3-beta	B	7.11	pIC50	78	nM	IC50	Eur J Med Chem (2009) 44: 2361-2371 [PMID:18929433]
ChEMBL	Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counting	B	7.11	pIC50	77	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1693-1696 [PMID:20138512]
ChEMBL	Inhibition of human full length GSK3beta expressed in baculovirus in Sf9 insect cells using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate by ADP-Glo kinase assay	B	7.27	pIC50	54	nM	IC50	Eur J Med Chem (2021) 222: 113554-113554 [PMID:34098466]
ChEMBL	Inhibition of human recombinant GSK3beta using GSM as substrate incubated for 30 mins by luminescence based assay	B	7.3	pIC50	50	nM	IC50	ACS Med Chem Lett (2019) 10: 469-474 [PMID:30996781]
GtoPdb	-	-	7.42	pIC50	~38	nM	IC50	Chem Biol (2000) 7: 793-803 [PMID:11033082]
ChEMBL	Inhibition of GSK-3beta (unknown origin)	B	7.47	pIC50	34	nM	IC50	J Med Chem (2021) 64: 26-41 [PMID:33346659]
ChEMBL	Stimulation of glycogen synthase in CHO cells expressing human insulin receptor	F	4.34	pEC50	45600	nM	EC50	J Med Chem (2003) 46: 3333-3341 [PMID:12852764]
ChEMBL	Induced beta-casein protein expression in the CHO-hIR cell line	F	4.51	pEC50	30620	nM	EC50	J Med Chem (2003) 46: 3333-3341 [PMID:12852764]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	6.3	pIC50	501.19	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]