ChEMBL ligand: CHEMBL1508 (Cipralex, Escitalopram, Esertia, Esitol, LU-26-054)
DAT/Dopamine transporter in Rat [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] SERT/Serotonin transporter in Rat [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] There should be some charts here, you may need to enable JavaScript!
Transporter in Rat [ChEMBL: CHEMBL6184] [UniProtKB: Q63380] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL	Displacement of [3H]WIN-35428 from DAT in rat caudate-putamen by scintillation counting	B	5.09	pKi	8150	nM	Ki	J Med Chem (2010) 53: 6112-6121 [PMID:20672825]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL	Binding affinity to human SERT expressed in African green monkey COS7 cells after 2 hrs by scintillation counting analysis	B	8.59	pKd	2.6	nM	Kd	ACS Med Chem Lett (2014) 5: 696-699 [PMID:24944746]
GtoPdb	-	-	8.68	pKd	2.1	nM	Kd	Nature (2016) 532: 334-9 [PMID:27049939]
ChEMBL	Inhibition of human SERT S438T mutant expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assay	B	5.1	pKi	7879	nM	Ki	J Med Chem (2015) 58: 5609-5619 [PMID:26153715]
ChEMBL	Inhibition of 5-hydroxy[3H]tryptamine uptake at human SERT expressed in African green monkey COS7 cells incubated for 10 mins prior to radioligand addition measured after 5 mins by scintillation counting analysis	B	8.13	pKi	7.4	nM	Ki	ACS Med Chem Lett (2014) 5: 696-699 [PMID:24944746]
ChEMBL	Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assay	B	8.66	pKi	2.2	nM	Ki	J Med Chem (2015) 58: 5609-5619 [PMID:26153715]
ChEMBL	Displacement of [125I]-RTI-55 from human SERT expressed in HEK293 cell membranes after 1 hr by gamma counting method	B	8.75	pKi	1.77	nM	Ki	Bioorg Med Chem Lett (2018) 28: 3431-3435 [PMID:30266542]
ChEMBL	Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assay	B	9	pKi	1	nM	Ki	Bioorg Med Chem Lett (2009) 19: 5552-5555 [PMID:19720528]
ChEMBL	Displacement of [3H]citalopram form human SRET by liquid scintillation counting	B	9	pKi	1	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2983-2986 [PMID:20347298]
ChEMBL	Allosteric modulation at wild-type human SERT site S2 expressed in african green monkey COS7 cells assessed as inhibition of [3H]citalopram dissociation at 30 uM by scintillation counting analysis	B	5.34	pIC50	4600	nM	IC50	J Med Chem (2013) 56: 9709-9724 [PMID:24237160]
ChEMBL	Displacement of [3H]-S-citalopram from human SERT primary site (S1) expressed in African green monkey COS7 cell membranes after 2 hrs by microbeta scintillation counting method	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2017) 27: 470-478 [PMID:28041833]
ChEMBL	Inhibition of [3H]5-HT uptake by SERT primary site (S1) (unknown origin) expressed in African green monkey COS1 cells after 10 mins by TopCount scintillation counting method	B	8.68	pIC50	2.1	nM	IC50	Bioorg Med Chem Lett (2017) 27: 470-478 [PMID:28041833]
GtoPdb	-	-	9	pIC50	1	nM	IC50	Bioorg Med Chem Lett (2009) 19: 5552-5 [PMID:19720528]
ChEMBL	Inhibition of [3H]-S-citalopram dissociation from human SERT allosteric modulator site (S2) expressed in African green monkey COS7 cell membranes after 80 mins by microbeta scintillation counting method	B	5.24	pEC50	5800	nM	EC50	Bioorg Med Chem Lett (2017) 27: 470-478 [PMID:28041833]
ChEMBL	Inhibition of [3H]-S-citalopram dissociation from SERT allosteric modulator site (S2) (unknown origin) expressed in African green monkey COS1 cell membranes by scintillation counting method	B	5.29	pEC50	5100	nM	EC50	Bioorg Med Chem Lett (2017) 27: 470-478 [PMID:28041833]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL	Displacement of [3H]citalopram from SERT in rat brain stem by scintillation counting	B	9.05	pKi	0.89	nM	Ki	J Med Chem (2010) 53: 6112-6121 [PMID:20672825]
Transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6184] [UniProtKB: Q63380]
ChEMBL	Displacement of [3H]nisoxetine from NET in rat frontal cortex by scintillation counting	B	4.98	pKi	10500	nM	Ki	J Med Chem (2010) 53: 6112-6121 [PMID:20672825]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]