E6201 [Ligand Id: 7836] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1097999 (E-6201, E6201, ER-806201) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
| ChEMBL | Inhibition of MEK1 (unknown origin) phosphorylation by [gamma-33P]-ATP assay | B | 7.3 | pIC50 | 50 | nM | IC50 | Eur J Med Chem (2019) 178: 468-483 [PMID:31207462] |
| ChEMBL | Inhibition of MEK1 (unknown origin) using ERK2 as substrate after 40 mins by ELISA | B | 7.89 | pIC50 | 13 | nM | IC50 | US-20090082313-A1. Multikinase inhibitors for use in the treatment of cancer (2009) |
| GtoPdb | - | - | 8.28 | pIC50 | 5.2 | nM | IC50 | J Pharmacol Exp Ther (2009) 331: 485-95 [PMID:19684251] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of FLT3 (unknown origin) phosphorylation by [gamma-33P]-ATP assay | B | 8.3 | pIC50 | 5 | nM | IC50 | Eur J Med Chem (2019) 178: 468-483 [PMID:31207462] |
| mitogen-activated protein kinase kinase kinase 1 in Human [GtoPdb: 2069] [UniProtKB: Q13233] | ||||||||
| GtoPdb | - | - | 7.51 | pIC50 | 31 | nM | IC50 | J Pharmacol Exp Ther (2009) 331: 485-95 [PMID:19684251] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
