E6201 [Ligand Id: 7836] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1097999 (E-6201, E6201, ER-806201) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
| ChEMBL | Inhibition of MEK1 (unknown origin) phosphorylation by [gamma-33P]-ATP assay | B | 7.3 | pIC50 | 50 | nM | IC50 | Eur J Med Chem (2019) 178: 468-483 [PMID:31207462] |
| ChEMBL | Inhibition of MEK1 (unknown origin) using ERK2 as substrate after 40 mins by ELISA | B | 7.89 | pIC50 | 13 | nM | IC50 | US-20090082313-A1. Multikinase inhibitors for use in the treatment of cancer (2009) |
| GtoPdb | - | - | 8.28 | pIC50 | 5.2 | nM | IC50 | J Pharmacol Exp Ther (2009) 331: 485-95 [PMID:19684251] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of FLT3 (unknown origin) phosphorylation by [gamma-33P]-ATP assay | B | 8.3 | pIC50 | 5 | nM | IC50 | Eur J Med Chem (2019) 178: 468-483 [PMID:31207462] |
| mitogen-activated protein kinase kinase kinase 1 in Human [GtoPdb: 2069] [UniProtKB: Q13233] | ||||||||
| GtoPdb | - | - | 7.51 | pIC50 | 31 | nM | IC50 | J Pharmacol Exp Ther (2009) 331: 485-95 [PMID:19684251] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
