Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1380 (Abacavir, Avacavir, Epzicom, NSC-742406, Ziagen) |
---|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
ChEMBL | Inhibition on HIV1 reverse transcriptase p66/p51 | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem (2009) 17: 1739-1746 [PMID:19179082] |
ChEMBL | In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant | B | 4.81 | pEC50 | 15500 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 1993-1996 [PMID:12781181] |
ChEMBL | In vitro antiviral activity against HIV-1 Reverse transcriptase wild type | B | 5.28 | pEC50 | 5300 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 1993-1996 [PMID:12781181] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]