abacavir [Ligand Id: 11152] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1380 (Abacavir, Avacavir, Epzicom, NSC-742406, Ziagen) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
| ChEMBL | Inhibition on HIV1 reverse transcriptase p66/p51 | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem (2009) 17: 1739-1746 [PMID:19179082] |
| ChEMBL | In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant | B | 4.81 | pEC50 | 15500 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 1993-1996 [PMID:12781181] |
| ChEMBL | In vitro antiviral activity against HIV-1 Reverse transcriptase wild type | B | 5.28 | pEC50 | 5300 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 1993-1996 [PMID:12781181] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
