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ChEMBL ligand: CHEMBL1380 (Abacavir, Avacavir, Epzicom, NSC-742406, Ziagen) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
ChEMBL | Inhibition on HIV1 reverse transcriptase p66/p51 | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg. Med. Chem. (2009) 17: 1739-1746 [PMID:19179082] |
ChEMBL | In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant | B | 4.81 | pEC50 | 15500 | nM | EC50 | Bioorg. Med. Chem. Lett. (2003) 13: 1993-1996 [PMID:12781181] |
ChEMBL | In vitro antiviral activity against HIV-1 Reverse transcriptase wild type | B | 5.28 | pEC50 | 5300 | nM | EC50 | Bioorg. Med. Chem. Lett. (2003) 13: 1993-1996 [PMID:12781181] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]