abacavir [Ligand Id: 11152] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1380 (Abacavir, Avacavir, Epzicom, NSC-742406, Ziagen)
  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Inhibition on HIV1 reverse transcriptase p66/p51 B 6.89 pIC50 130 nM IC50 Bioorg Med Chem (2009) 17: 1739-1746 [PMID:19179082]
ChEMBL In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant B 4.81 pEC50 15500 nM EC50 Bioorg Med Chem Lett (2003) 13: 1993-1996 [PMID:12781181]
ChEMBL In vitro antiviral activity against HIV-1 Reverse transcriptase wild type B 5.28 pEC50 5300 nM EC50 Bioorg Med Chem Lett (2003) 13: 1993-1996 [PMID:12781181]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]