abacavir [Ligand Id: 11152] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1380 (Abacavir, Avacavir, Epzicom, NSC-742406, Ziagen)
  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Inhibition on HIV1 reverse transcriptase p66/p51 B 6.89 pIC50 130 nM IC50 Bioorg. Med. Chem. (2009) 17: 1739-1746 [PMID:19179082]
ChEMBL In vitro antiviral activity against HIV-1 Reverse transcriptase M184V mutant B 4.81 pEC50 15500 nM EC50 Bioorg. Med. Chem. Lett. (2003) 13: 1993-1996 [PMID:12781181]
ChEMBL In vitro antiviral activity against HIV-1 Reverse transcriptase wild type B 5.28 pEC50 5300 nM EC50 Bioorg. Med. Chem. Lett. (2003) 13: 1993-1996 [PMID:12781181]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]