compound 1 [PMID: 28379944] [Ligand Id: 11930] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL289472 (L-161638)
  • Angiotensin II type 1a (AT-1a) receptor in Rabbit [ChEMBL: CHEMBL3948] [UniProtKB: P34976]
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  • AT2 receptor in Human [GtoPdb: 35] [UniProtKB: P50052]
  • AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351]
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  • AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin II type 1a (AT-1a) receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3948] [UniProtKB: P34976]
ChEMBL Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane B 6.7 pIC50 200 nM IC50 Bioorg Med Chem Lett (1994) 4: 1479-1484
AT2 receptor in Human [GtoPdb: 35] [UniProtKB: P50052]
GtoPdb - - 9.47 pKi 0.34 nM Ki Nature (2017) 544: 327-332 [PMID:28379944]
AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351]
ChEMBL Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane B 10.22 pIC50 0.06 nM IC50 Bioorg Med Chem Lett (1994) 4: 1479-1484
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
GtoPdb - - 6.74 pKi 180 nM Ki Nature (2017) 544: 327-332 [PMID:28379944]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]