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ChEMBL ligand: CHEMBL289472 (L-161638) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Angiotensin II type 1a (AT-1a) receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3948] [UniProtKB: P34976] | ||||||||
ChEMBL | Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1479-1484 |
AT2 receptor in Human [GtoPdb: 35] [UniProtKB: P50052] | ||||||||
GtoPdb | - | - | 9.47 | pKi | 0.34 | nM | Ki | Nature (2017) 544: 327-332 [PMID:28379944] |
AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351] | ||||||||
ChEMBL | Displacement of [125 I]Sar1Ile8-AII from AT2 receptor of rat midbrain membrane | B | 10.22 | pIC50 | 0.06 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1479-1484 |
Angiotensinogen in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5291508] [UniProtKB: P01015] | ||||||||
ChEMBL | Binding affinity to AT2 in rat brain | B | 9.66 | pIC50 | 0.22 | nM | IC50 | Eur J Med Chem (2018) 151: 628-685 [PMID:29656203] |
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
GtoPdb | - | - | 6.74 | pKi | 180 | nM | Ki | Nature (2017) 544: 327-332 [PMID:28379944] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]